Zobrazeno 1 - 10
of 90
pro vyhledávání: '"T1AM"'
Publikováno v:
FEBS Open Bio, Vol 7, Iss 4, Pp 587-601 (2017)
3‐Iodothyronamine (T1AM) is a structural analog of thyroid hormone that has been demonstrated to have potent affects on numerous physiological systems. Most studies on T1AM have explored its effects in healthy functional systems; while its potentia
Externí odkaz:
https://doaj.org/article/3415cbd9963c4400ac2e9029fb4873ec
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Mast cells are primary players in immune and inflammatory diseases. In the brain, mast cells are located at the brain side of the blood brain barrier (BBB) exerting a crucial role in protecting the brain from xenobiotic invasion. Furthermore, recent
Externí odkaz:
https://doaj.org/article/5edfa8bc6deb42a38fbd5cc0e4ab1edc
Autor:
Nicoletta di Leo, Stefania Moscato, Marco Borso', Simona Sestito, Beatrice Polini, Lavinia Bandini, Agostina Grillone, Matteo Battaglini, Alessandro Saba, Letizia Mattii, Gianni Ciofani, Grazia Chiellini
Publikováno v:
Molecules, Vol 26, Iss 6, p 1616 (2021)
Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by mo
Externí odkaz:
https://doaj.org/article/e435b422fb3c49aead6f74adcabf3ac9
Autor:
Manuela Gencarelli, Annunziatina Laurino, Elisa Landucci, Daniela Buonvicino, Costanza Mazzantini, Grazia Chiellini, Laura Raimondi
Publikováno v:
Biology, Vol 9, Iss 5, p 95 (2020)
We investigated the effect of 3-iodothyronamine (T1AM) on thermogenic substrates in brown adipocytes (BAs). BAs isolated from the stromal fraction of rat brown adipose tissue were exposed to an adipogenic medium containing insulin in the absence (M)
Externí odkaz:
https://doaj.org/article/97b23808c1ff491ebdd973dd7184a497
Autor:
Lorenza Bellusci, Massimiliano Runfola, Vittoria Carnicelli, Simona Sestito, Federica Fulceri, Filippo Santucci, Paola Lenzi, Francesco Fornai, Simona Rapposelli, Nicola Origlia, Riccardo Zucchi, Grazia Chiellini
Publikováno v:
Molecules, Vol 25, Iss 5, p 1054 (2020)
3-iodothyronamine (T1AM) and the recently developed analog SG-2 are rapidly emerging as promising multi-target neuroprotective ligands able to reprogram lipid metabolism and to produce memory enhancement in mice. To elucidate the molecular mechanisms
Externí odkaz:
https://doaj.org/article/a4dbe6491f2443d3867d1e277e057fea
Autor:
Ruy A. Louzada, Denise P. Carvalho
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Thyroxine (T4) and 3,5,3'-triiodothyronine (T3) are secreted by the thyroid gland, while T3 is also generated from the peripheral metabolism of T4 by iodothyronine deiodinases types I and II. Several conditions like stress, diseases, and physical exe
Externí odkaz:
https://doaj.org/article/cdb87063a3f2446a9dc3161ecf9c3569
Autor:
Xiaoqun Zhang, Ioannis Mantas, Alexandra Alvarsson, Takashi Yoshitake, Mohammadreza Shariatgorji, Marcela Pereira, Anna Nilsson, Jan Kehr, Per E. Andrén, Mark J. Millan, Karima Chergui, Per Svenningsson
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized. Here, we examined the regulation of tyrosine hydroxylase (
Externí odkaz:
https://doaj.org/article/830f7dc0f7f8452fbd516f268cdae62d
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2018)
TAAR1 is widely expressed across the mammalian brain, particularly in limbic and monoaminergic areas, allegedly involved in mood, attention, memory, fear, and addiction. However, the subcellular distribution of TAAR1 is still unclear, since TAAR1 sig
Externí odkaz:
https://doaj.org/article/a44af879453e4d3caa963c711294c5de
Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/0f6bbb055d294208b6c9b085e756fe9b
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
3-Monoiodothyronamine (T1AM), first isolated from rat brain, is reported to be an endogenous, rapidly acting metabolite of thyroxine. One of its numerous effects is the induction of a “torpor-like” state in experimental animals. A critical analys
Externí odkaz:
https://doaj.org/article/ad80a2f4a24846cf9b032e9b8c44e146