Negative symptoms and longitudinal grey matter tissue loss in adolescents at risk of psychosis: Preliminary findings from a 6-year follow-up study

Autor: Andrew C. Stanfield, Stephen M. Lawrie, David G. C. Owens, Heather C. Whalley, T.W. Moorhead, Eve C. Johnstone, Andrew McKechanie

Publikováno v: McKechanie, A, Moorhead, T W J, Stanfield, A C, Whalley, H C, Johnstone, E, Lawrie, S M & Owens, D G C 2016, ' Negative symptoms and longitudinal gray matter tissue loss in adolescents at risk of psychosis : Preliminary findings from a 6-year follow-up study. ', British Journal of Psychiatry, vol. 208, no. 6, pp. 565-570 . https://doi.org/10.1192/bjp.bp.114.154526

BackgroundNegative symptoms are perhaps the most disabling feature of schizophrenia. Their pathogenesis remains poorly understood and it has been difficult to assess their development over time with imaging techniques.AimsTo examine, using tensor-bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddffb2e9f6ff1a6e6af855b82ebe134
https://doi.org/10.1192/bjp.bp.114.154526

Between- and within-scanner variability in the CaliBrain study n-back cognitive task

Autor: David J. McGonigle, Gordon D. Waiter, John Douglas Steele, Barrie Condon, Alison D. Murray, Katherine Lymer, David Brennan, Stephen M. Lawrie, Victoria B. Gradin, Donald M. Hadley, Joanna M. Wardlaw, Ian Marshall, T.W. Moorhead, Trevor Ahearn, Dominic Job, Andrew M. McIntosh, Viktoria-Eleni Gountouna, Jonathan Cavanagh, Heather C. Whalley

Publikováno v: Psychiatry Research: Neuroimaging. 184:86-95

Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face prob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd00fb0afc24ffa809786d36371f121c
https://doi.org/10.1016/j.pscychresns.2010.08.010

A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia

Autor: S. Muñoz Maniega, D. C. G. Owens, T.W. Moorhead, Eve C. Johnstone, D. Marjoram, Dominic Job, G.K.S. Lymer, Andrew M. McIntosh, Stephen M. Lawrie, Mark E. Bastin

Publikováno v: Schizophrenia Research. 106:132-139

Diffusion tensor imaging (DTI) has previously shown compromised white matter integrity in frontotemporal white matter fibers in patients with schizophrenia, as indicated by reduced fractional anisotropy (FA). In the present study we investigated whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1693dbf9a36d6c292c3001ab0719029
https://doi.org/10.1016/j.schres.2008.09.016

Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa

Autor: Barrie Condon, Paola Dazzan, David Brennan, T.W. Moorhead, Shane McKie, Dominic Job, G. Katherine S. Lymer, Tiago Reis Marques, Anna Barnes, Bill Deakin, Steve R. Williams, Stephen M. Lawrie, Clare E. Mackay, Steven Williams, John Suckling, Mahsa Shokouhi

Publikováno v: BMC Medical Imaging, Vol 11, Iss 1, p 23 (2011)
Shokouhi, M, Barnes, A, Suckling, J, Moorhead, T W, Brennan, D, Job, D, Lymer, K, Dazzan, P, Reis Marques, T, Mackay, C, McKie, S, Williams, S C, Lawrie, S M, Deakin, B, Williams, S R & Condon, B 2011, ' Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa ', BMC medical imaging, vol. 11, pp. 23 . https://doi.org/10.1186/1471-2342-11-23
BMC Medical Imaging

Background Brain morphometry is extensively used in cross-sectional studies. However, the difference in the estimated values of the morphometric measures between patients and healthy subjects may be small and hence overshadowed by the scanner-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd8aa14aeea64424b8bd1316b973608
http://www.biomedcentral.com/1471-2342/11/23

Reduced prefrontal gyrification in obsessive-compulsive disorder

Autor: Peter Falkai, Susanne Kraft, Anne Klinghardt, Thomas Schneider-Axmann, Stephen M. Lawrie, T.W. Moorhead, Thomas Wobrock, Wolfgang Reith, Harald Scherk, Andrew M. McIntosh, Oliver Gruber

Publikováno v: Wobrock, T, Gruber, O, McIntosh, A M, Kraft, S, Klinghardt, A, Scherk, H, Reith, W, Schneider-Axmann, T, Lawrie, S M, Falkai, P & Moorhead, T W 2010, ' Reduced prefrontal gyrification in obsessive-compulsive disorder ', European archives of psychiatry and clinical neuroscience, vol. 260, no. 6, pp. 455-464 . https://doi.org/10.1007/s00406-009-0096-z
European Archives of Psychiatry and Clinical Neuroscience

Structural magnetic resonance imaging (MRI) studies reveal evidence for brain abnormalities in obsessive–compulsive disorder (OCD), for instance, reduction of gray matter volume in the prefrontal cortex. Disturbances of gyrification in the prefront

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c5ce28b7bf75c8caa9bbf60df5c411
https://www.pure.ed.ac.uk/ws/files/8720395/Reduced_prefrontal_gyrification_in_obsessive_compulsive_disorder.pdf