Zobrazeno 1 - 10
of 51
pro vyhledávání: '"T.W. Harper"'
Autor:
Jiang Wen, Anzhi Wei, Ruth R. Wexler, Jeffrey M. Bozarth, Dietmar A. Seiffert, Joseph M. Luettgen, Delucca Indawati, Nicholas R. Wurtz, Pancras C. Wong, T.W. Harper, Brandon Parkhurst, Xiaojun Zhang, Daniel L. Cheney, E. Scott Priestley, Peter W. Glunz, Yiming Wu, Alan R. Rendina
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
Factor VIIa (FVIIa) inhibitors have shown strong antithrombotic efficacy in preclinical thrombosis models with limited bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful due to the requirement of a
Publikováno v:
Journal of Sustainable Agriculture. 32:231-253
Over the past century, a significant proportion of the native grasslands that once occupied much of the middle third of the United States have been converted to cultivated agriculture, causing short- and long-term variations in soil physical and hydr
Autor:
A A Seymour, William N. Washburn, Dorothy Slusarchyk, P.J. McCann, B.E. Abboa-Offei, Minsheng Zhang, G.T. Allen, Ravindar N. Girotra, B.H. Frohlich, Michael Cap, Jollie D. Godfrey, Peter T. W. Cheng, R.J. George, C. Shao, Anita D. Russell, S. Skwish, Philip M. Sher, Jon J. Hangeland, A.V. Gavai, T.L. Waldron, Belay Tesfamariam, Yolanda Caringal, T.W. Harper, Tamara Dejneka, Kenneth E.J. Dickinson, Ginger Wu, Syed Z. Ahmed, Amarendra B. Mikkilineni, Hongwei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4290-4296
Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta(3) agonists is complicated by their propensity to undergo metabolic oxidative N-dealkylation, generating 0.01-2% of a very potent alpha(1) adrenergic agonis
Autor:
Liesl G. Fisher, P.J. McCann, D.A. Young, C.M. Arbeeny, S. Skwish, Amarendra B. Mikkilineni, Poss Kathleen M, G.T. Allen, Chongqing Sun, Michael Cap, R.J. George, Dorothy Slusarchyk, B.E. Abboa-Offei, Ravindar N. Girotra, William N. Washburn, Carl P. Ciosek, A.V. Gavai, Belay Tesfamariam, T.W. Harper, Ginger Wu, B.H. Frohlich, D.E. Hillyer, Tammy C. Wang, A A Seymour, Mark S. Bednarz, Philip M. Sher, Kenneth E.J. Dickinson, T.L. Waldron, Arvind Mathur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3041-3044
A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent beta(3) full agonist (K(i)=
Autor:
Huabin Sun, Joseph Prol, Karnail S. Atwal, T.W. Harper, Yolanda Caringal, Michael A. Blanar, Ruth R. Wexler, Jinping Gan, Christine Huang, Wayne Vaccaro, Alexander Kover, Paul Levesque, Heather Finlay, Lin Yan, John Lloyd, John D. Dimarco, Mary Lee Conder, Tram N. Huynh, Bhandaru Rao S, Gauri Bhave
Publikováno v:
Journal of medicinal chemistry. 55(7)
Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of I(Kur) current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When sub
Autor:
Z. Merchant, S. Skwish, Dorothy Slusarchyk, P.J. McCann, D.A. Young, M. Morella, Kenneth E.J. Dickinson, Michael Cap, Ravindar N. Girotra, Anita D. Russell, B.E. Abboa-Offei, William N. Washburn, G.T. Allen, A.V. Gavai, Belay Tesfamariam, Peter T. W. Cheng, G. S. Bisacchi, Tammy C. Wang, A A Seymour, T.W. Harper, C.M. Arbeeny, Tamara Dejneka, Amarendra B. Mikkilineni, Poss Kathleen M, Chongqing Sun, Philip M. Sher, T.L. Waldron, R.J. George, B.H. Frohlich, Ginger Wu, Denis E. Ryono
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human β3 adrenergic receptor agonist activity. SAR studies led to the identification of BMS-201620 (39), a potent β3 full agonist (Ki=93 nM
Autor:
Kenneth E.J. Dickinson, Michael Cap, Peter T. W. Cheng, A.V. Gavai, Arvind Mathur, Belay Tesfamariam, G.T. Allen, T.W. Harper, D.E. Hillyer, Tamara Dejneka, Dorothy Slusarchyk, S. Skwish, P.J. McCann, Chongqing Sun, Richard E. Gregg, D.A. Young, Carl P. Ciosek, Tammy C. Wang, Ravindar N. Girotra, Philip M. Sher, B.E. Abboa-Offei, A A Seymour, William N. Washburn, C.M. Arbeeny, Amarendra B. Mikkilineni, Poss Kathleen M, T.L. Waldron, R.J. George, B.H. Frohlich, Anita D. Russell, Denis E. Ryono
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(23)
Screening of the BMS collection identified 4-hydroxy-3-methylsulfonanilidoethanolamines as full beta 3 agonists. Substitution of the ethanolamine nitrogen with a benzyl group bearing a para hydrogen bond acceptor promoted beta(3) selectivity. SAR elu
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