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Low temperature incorporation of bovine serum albumin into a bead formed macroporous hydrophilic polymer matrix with potential for sustained release

Autor: Brian J. Tighe, Roisin L. McCallion, T.W. Atkins

Publikováno v: Journal of Biomaterials Science, Polymer Edition. 3:261-274

A process of freeze-thaw polymerization involving the low temperature photopolymerization of a mixed solution of monomers and bovine serum albumin around frozen ice crystals has been used to generate a bead formed macroporous hydrophilic matrix with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae4855ba5f789b5637dc61544395327
https://doi.org/10.1163/156856292x00178

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Vancomycin release from blended polyester microspheres

Autor: T.W. Atkins, David Yates

Publikováno v: Drug delivery. 5(1)

O/W emulsification with solvent evaporation was used to fabricate spherical (5-100 microm) vancomycin loaded microspheres, either smooth surfaced with macroporous interior (PLCG 50:50), smooth surfaced and monolithic (PEAD), smooth surfaced (50% PEAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f405fc0343d3816a85bf41cebad7d7e
https://pubmed.ncbi.nlm.nih.gov/19570019

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Fabrication of microspheres using blends of poly(ethylene adipate) and poly(ethylene adipate)/poly(hydroxybutyrate-hydroxyvalerate) with poly(caprolactone): incorporation and release of bovine serum albumin

Autor: T.W. Atkins

Publikováno v: Journal of biomaterials science. Polymer edition. 8(11)

Spherical microspheres composed of polymer blends 80:20 PEAD/PCL II and 40:40:20 PEAD/P(HB-HV)/PCL II containing a range of BSA loadings have been fabricated using a single emulsion technique with solvent evaporation. 80:20 PEAD/PCL II microspheres h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d34226d5e04a15b2e18c26281e0d56
https://pubmed.ncbi.nlm.nih.gov/9342650

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Preliminary in vitro cytotoxicity screening of a bead-formed macroporous hydrophilic polymer matrix

Autor: T.W. Atkins, Brian J. Tighe

Publikováno v: Journal of biomaterials science. Polymer edition. 7(9)

A prescreen of the in vitro cytotoxicity of both the primary fabrication components and potential leachables from a bead-formed macroporous poly(2-hydroxyethyl methacrylate), (pHEMA) matrix has been carried out using INVITTOX Neutral red and Kenacid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed31ce26b2781fb1e6be6a05692266e5
https://pubmed.ncbi.nlm.nih.gov/8773880

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In vitro biodegradation of poly(beta-hydroxybutyrate-hydroxyvalerate) microspheres exposed to Hanks' buffer, newborn calf serum, pancreatin and synthetic gastric juice

Autor: T.W. Atkins, Sarah J. Peacock

Publikováno v: Journal of biomaterials science. Polymer edition. 7(12)

Spherical BSA loaded microporous matrix type microspheres composed of P(HB-HV) blended with 20% PCL II and fabricated using 0/W emulsification with solvent evaporation have been incubated in Hanks' buffer, pH 7.4; newborn calf serum; 1.5% pancreatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb21942c03455ec009839c36427942f7
https://pubmed.ncbi.nlm.nih.gov/8880439

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The incorporation and release of bovine serum albumin from poly(beta-hydroxybutyrate-hydroxyvalerate) microspheres

Autor: T.W. Atkins, Sarah J. Peacock

Publikováno v: Journal of biomaterials science. Polymer edition. 7(12)

Spherical microporous matrix type microspheres composed of 330 kD P(HB-HV) (10.8% HV) 20%PCL II containing a range of %BSA loadings have been fabricated using a single emulsion technique with solvent evaporation. Microspheres were generated in high y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f781da80cdff6d0178ea74926b42145
https://pubmed.ncbi.nlm.nih.gov/8880438

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The incorporation and release of glucose oxidase and interleukin 2 from a bead formed macroporous hydrophilic polymer matrix

Autor: Roisin L. McCallion, T.W. Atkins, Brian J. Tighe

Publikováno v: Journal of biomaterials science. Polymer edition. 6(7)

Freeze-thaw photopolymerization at low temperature of a mixed solution of 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EDM), and either glucose oxidase (GOx) or interleukin 2 (IL-2) around frozen ice crystals has been used to g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748950ef2f3a89fc463363d399f8edc9
https://pubmed.ncbi.nlm.nih.gov/7873516

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Incorporation and release of fluorescein isothiocyanate-linked dextrans from a bead-formed macroporous hydrophilic matrix with potential for sustained release

Autor: R.L. McCallion, T.W. Atkins, B.J. Tighe

Publikováno v: Biomaterials. 14(1)

Freeze-thaw polymerization has been used to generate a bead-formed (100-3000 microns) macroporous hydrophilic matrix with potential for the sustained release of macromolecules. While the incorporation of FITC-dextrans marginally increased the equilib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c1ce42c50a08caa19f98e48667e07f
https://pubmed.ncbi.nlm.nih.gov/7678754

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The effect of digitoxose on insulin release, glucose oxidation and oxygen consumption by islets of lean and genetically obese diabetic (OBOB) mice

Autor: M. Hussain, T.W. Atkins

Publikováno v: Biochemical and Biophysical Research Communications. 129:358-367

Digitoxose specifically and competitively inhibited glucose stimulated insulin release from islets of both lean and obese mice without affecting either the rate of glucose oxidation or the rate of glucose stimulated oxygen consumption. Obese mouse is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9728fc6893294940f15589f416df833
https://doi.org/10.1016/0006-291x(85)90159-7

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