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pro vyhledávání: '"T.R. Vedamanda"'
Autor:
Terence J. Scallen, T.R. Vedamanda, John A. Brinkman, Lawerence B. Perez, Fell Jay Bradford, Robert E. Damon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2491-2494
Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibito