Výsledky vyhledávání - "T.R. Narasimhan"

Sublethal detoxification responses to contaminant exposure associated with offshore production platforms

Autor: T.R. Narasimhan, Cynthia M. Erickson, Stephen Safe, Susanne J. McDonald, Kristine L. Willett, Karla B. Beatty, Jane Thomsen, K. Connor

Publikováno v: Canadian Journal of Fisheries and Aquatic Sciences. 53:2606-2617

Plusieurs marqueurs biologiques de l'exposition aux hydrocarbures aromatiques ont ete utilises pour evaluer la contamination associee a la mise en valeur et a la production de petrole et de gaz dans le golfe du Mexique. Plusieurs especes de poisson e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15e333a319c467cd6517d49d96564f4d
https://doi.org/10.1139/f96-217

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Exposure of killifish to benzo[a]pyrene: comparative metabolism, DNA adduct formation and aryl hydrocarbon (Ah) receptor agonist activities

Autor: Jane Thomsen, Susanne J. McDonald, Mahlon C. Kennicutt, T.R. Narasimhan, Karla B. Beatty, M. Steinberg, Stephen Safe, Kristine L. Willett

Publikováno v: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 112:93-103

Benzo[a]pyrene (BaP) elicited a dose-response induction of hepatic CYP1A1 gene expression in killifish characterized by increased CYP1A1 mRNA levels, ethoxyresorufin O-deethylase (EROD) and aryl hydrocarbon hydroxylase (AHH) activities. There were ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::170d56b4426fd068097d58eaff759778
https://doi.org/10.1016/0305-0491(95)00034-6

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Mechanism of 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells

Autor: T.R. Narasimhan, Stephen Safe, X. Wang, Weston Porter, Venkatesh Krishnan

Publikováno v: Molecular and Cellular Endocrinology. 96:159-166

Treatment of MCF-7 cells with 1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 1 nM [3H]17 beta-estradiol resulted in decreased radiolabeled nuclear estrogen receptor (ER) levels as determined by velocity sedimentation analysis. In parallel studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094e9473b136f253d1fcb4796932e022
https://doi.org/10.1016/0303-7207(93)90106-t

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Potentiation of CYP1A1 Gene Expression in MCF-7 Human Breast Cancer Cells Cotreated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and 12-O-Tetradecanoylphorbol-13-Acetate

Autor: Stephen Safe, X. Wang, M. Moore, M. Steinberg, T.R. Narasimhan

Publikováno v: Archives of Biochemistry and Biophysics. 305:483-488

In MCF-7 cells treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a time- and concentration-dependent modulation of TCDD-induced CYP1A1 gene expression. Treatment of MCF-7 cells with 1 nM TCDD f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e76393f1c6644d0d5372e0cb9f9bdb
https://doi.org/10.1006/abbi.1993.1451

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Structure-dependent reduction in DNA I-compound adducts by polychlorinated dibenzofurans in female Sprague-Dawley rat liver

Autor: X. Wang, Ranjani Reddy, Erika Randerath, Kurt Randerath, T.R. Narasimhan, S.H. Safe

Publikováno v: Chemosphere. 25:975-978

The effects of polychlorinated dibenzofurans (PCDFs) on hepatic I-compound DNA adducts in female Sprague-Dawley rats were determined at 2 dose levels. In the first experiments, rats (4 per group) were treated with each of 3 polychlorinated dibenzofur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81614c6a8843f8922110fd4f34e05d3c
https://doi.org/10.1016/0045-6535(92)90094-8

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2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiproliferative agent in human breast cancer cells: Effects on insulin-induced cell proliferation

Autor: T.R. Narasimhan, S.H. Safe, Hong Liu

Publikováno v: Chemosphere. 25:955-958

2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) elicits a broad spectrum of antiestrogenic responses in MCF-7 human breast cancer cells. Treatment of the cells with insulin (0.001 – 10.0 μg/ml) caused a significant concentration-dependent increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e2618e5dae1c616283a4cbda557eb7d
https://doi.org/10.1016/0045-6535(92)90091-5

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Gap Junctions in Myometrial Cell Cultures: Evidence for Modulation by Cyclic Adenosine 3′ :5′-Monophosphate1

Autor: Rola Barhoumi, Hugh Dookwah, Robert C. Burghardt, Stephen Safe, T.R. Narasimhan

Publikováno v: Biology of Reproduction. 47:397-407

Primary cultures of myometrial cells from juvenile rats, continuous cultures maintained by serial passage, and a pSV3neotransfected myometrial cell line were established and utilized for the study of development and modulation of gap junctional inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ec9ac0b8c6ec0dffef7a3439f1ab749
https://doi.org/10.1095/biolreprod47.3.397

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Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds

Autor: Stephen Safe, L. Biegel, C. Rowlands, H. Liu, T.R. Narasimhan

Publikováno v: Molecular and Cellular Endocrinology. 87:19-28

Insulin-like growth factor-I (IGF-I) stimulated the growth and [3H]thymidine uptake in MCF-7 human breast cancer cells grown in serum- and growth factor-inactivated serum-containing media. Cotreatment of the cells with IGF-I plus 2,3,7,8-tetrachlorod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d527b1e50a3020461e938ffa40a60481
https://doi.org/10.1016/0303-7207(92)90229-y

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Inhibition of estrogen- and growth factor-induced proliferation of human breast cancer cell lines by TCDD: characterization and mechanistic studies

Autor: T.R. Narasimhan, H. Lui, Mark A. Harris, S.H. Safe, L. Biegel, P. Fernandez

Publikováno v: Chemosphere. 25:83-86

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exhibits a broad spectrum of antiestrogenic effects in estrogen receptor (ER) positive MCF-7 human breast cancer cells. The proliferation of MCF-7 cells in minimal media can also be stimulated by other mitog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e99d4d2347375fb6e20053ce2a95d57a
https://doi.org/10.1016/0045-6535(92)90485-a

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Effects of hydroxylated polychlorinated biphenyls on mouse liver mitochondrial oxidative phosphorylation

Autor: H.L. Kim, Stephen Safe, T.R. Narasimhan

Publikováno v: Journal of Biochemical Toxicology. 6:229-236

The effects of three tetrachlorobiphenylols [2',3',4',5'-tetrachloro-2-biphenylol (1); 2',3',4',5'-tetrachloro-4- biphenylol (2); and 2',3',4',5'-tetrachloro-3-biphenylol (3)]; three monochlorobiphenylols [5-chloro-2-biphenylol (5), 3-chloro-2-biphen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1185459f1d77bd778f5efdde86092b6d
https://doi.org/10.1002/jbt.2570060309

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