Zobrazeno 1 - 10
of 27
pro vyhledávání: '"T.O. Oesterling"'
Nucleophilic Addition of Bisulfite Ion to Prostaglandins E2 and A2: Implication in Aqueous Stability
Publikováno v:
Journal of Pharmaceutical Sciences. 66:149-154
Evidence is presented to indicate that the bisulfite ion (HSO3-) adds across the C-9 carbonyl group of dinoprostone (prostaglandin E2) and across the delta 10,11- bond of prostaglandin A2. At room temperature, the apparent equilibrium constant, deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be66dbdf922ce1a1399b0b6a58cd4431
https://doi.org/10.1002/jps.2600660204
https://doi.org/10.1002/jps.2600660204
Autor:
T.O. Oesterling, Randall G. Stehle
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1590-1595
The stability of prostaglandin El and dinoprostone was investigated at the extremes of the pH range (≤ 3 and ≥ 10) in the sequence prostaglandin E → prostaglandin A → prostaglandin B. The degradation rate is first order with hydrogen-ion and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7770c29ea9c0a8e5167e949cacc9694
https://doi.org/10.1002/jps.2600661123
https://doi.org/10.1002/jps.2600661123
Autor:
T.O. Oesterling
Publikováno v:
Journal of Pharmaceutical Sciences. 59:63-67
The kinetics and mechanism of degradation of the antibiotic clindamycin were studied in buffered aqueous solution in the pH range 0.4-12. Clindamycin showed maximum stability at pH 3-5; however, high temperature studies indicated that not more than 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4dedd33b1ba437359f8948927eed1f
https://doi.org/10.1002/jps.2600590110
https://doi.org/10.1002/jps.2600590110
Autor:
T.O. Oesterling
Publikováno v:
Carbohydrate Research. 15:285-290
In alkaline media the 2-, 3-, and 4-monohexanoates of lincomycin rapidly isomerize, each entering into facile equilibrium with the other two, with accompanying hydrolysis of each species to lincomycin. In acid media, lincomycin 3-hexanoate and 4-hexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927a566a9a40e0ff30de83563d37908b
https://doi.org/10.1016/s0008-6215(00)88012-x
https://doi.org/10.1016/s0008-6215(00)88012-x
Autor:
T.O. Oesterling, Carl M. Metzler
Publikováno v:
Journal of Pharmaceutical Sciences. 61:287-291
In alkaline media the 2-, 3-, and 4-monohexanoates of lincomycin rapidly isomerize, each entering into facile equilibrium with the other two, accompanied by hydrolysis of each species to lincomycin. The concentration-time curves of the three esters a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653c127787f36446ff495c6457703d57
https://doi.org/10.1002/jps.2600610236
https://doi.org/10.1002/jps.2600610236
Publikováno v:
Journal of pharmaceutical sciences. 68(7)
A new method for synthesizing C1-aliphatic esters of dinoprost and dinoprostone without using hydroxyl protective groups is described. Reaction of the prostaglandin with an alkyl halide in the presence of the sterically hindered amine N,N-diisopropyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b300c2ad2ed03fb6416a068c89d05b66
https://pubmed.ncbi.nlm.nih.gov/458599
https://pubmed.ncbi.nlm.nih.gov/458599
Autor:
W.L. Miller, C.F. Lawson, T.O. Oesterling, S.L. Douglas, J. C. Cornette, J.R. Weeks, Walter Morozowich
Publikováno v:
Journal of pharmaceutical sciences. 68(8)
Methods are described for the synthesis of dinoprost C9- and C15-monoesters using protective groups. Esters at C9 were synthesized by acylation of dinoprost 11,15-bis(tetrahydropyran-2-yl)ether followed by acid-catalyzed protective group removal. Est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18f3ef0af511411911d20d667b9951a
https://pubmed.ncbi.nlm.nih.gov/113524
https://pubmed.ncbi.nlm.nih.gov/113524
Autor:
W. Moronzowich, T.O. Oesterling, W.L. Miller, S.L. Douglas, C.F. Lawson, J. C. Cornette, J.R. Weeks
Publikováno v:
Chemischer Informationsdienst. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9052bea242b68ac99b8b488b187012a
https://doi.org/10.1002/chin.197952294
https://doi.org/10.1002/chin.197952294
Autor:
T.O. Oesterling, W.L. Miller, Walter Morozowich, Randall G. Stehle, S.L. Douglas, J.R. Weeks, C.F. Lawson
Publikováno v:
Journal of pharmaceutical sciences. 68(7)
Dinoprostone para-substituted phenyl esters were synthesized in attempt to improve the solid-state stability of the parent prostaglandin. A phenol series covering a wide melting-point range was employed, and a linear relationship was observed between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de8d60a1ff3fbc28b2f84f9abfb3bbe
https://pubmed.ncbi.nlm.nih.gov/458598
https://pubmed.ncbi.nlm.nih.gov/458598
Autor:
J.H. Gustafson, T.O. Oesterling
Publikováno v:
Journal of pharmaceutical sciences. 59(11)
The kinetics and mechanism of degradation of 3β, 17α-dihydroxy-6α-methylpregn-4-en-20-one 17-acetate, 3-phosphate (I) was studied as a function of pH and temperature. At low pH the least stable moiety is the allylic phosphate ester at C3, while th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61c86cc70b2e2c94bb2f9e7e2eb4ff2
https://pubmed.ncbi.nlm.nih.gov/5495487
https://pubmed.ncbi.nlm.nih.gov/5495487