Zobrazeno 1 - 10
of 93
pro vyhledávání: '"T.M Jefferies"'
Publikováno v:
Human Reproduction. 14:2513-2516
The human epididymis provides an optimal environment for the storage and maturation of spermatozoa. However, the ability of the epididymis to protect spermatozoa from oxidative attack whilst stored at this site, through the local actions of antioxida
Publikováno v:
International Journal of Andrology. 22:282-288
Extra-epididymal spermatozoa account for approximately a third of all spermatozoa found in the normal human ejaculate. Whilst remaining outside of the testes at core body temperature, the functional competence of spermatozoa, including cell motility
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 423:103-111
Cigarette smoke is a rich source of mutagens and carcinogens; thus, we have investigated the effects of male smoking on the DNA of human sperm. This was performed using the sperm chromatin structure assay (SCSA), which measures the sensitivity of spe
Publikováno v:
Journal of Chromatography A. 818:239-249
Even though it is known that the enantiomers of a drug can exhibit different pharmacokinetic and dynamic properties, fencamfamine has been used in clinical practice as a mixture of four isomers, arising from the two centres of chirality in the molecu
Publikováno v:
Chirality. 9:211-219
NMR spectroxcopy has been used to compare the interaction of ephedrine and N-methylephedrine with β-cyclodextrin, heptakis(2,3-di-O-acetyl)β-cyclodextrin, heptakis(6-O-acetyl)β-cyclodextrin. The stoichiometry of the complexes formed between all th
Publikováno v:
Journal of Chromatography A. 758:277-292
The effect of acetylation of β-cyclodextrin (CD) on the chiral discrimination of a series of phenethylamines has been investigated using capillary electrophoresis and nuclear magnetic resonance (NMR) spectroscopy. Therefore, pure, fully derivatized
Publikováno v:
Chirality. 8:126-130
A β-cyclodextrin bonded stationary phase was employed for the enantioresolution of propranolol and several analogues in conjunction with various polar organic mobile phases. The effects of structural alterations in the non-polar regions of the analy
Publikováno v:
Journal of Chromatography A. 705:351-361
The enantio-resolution of propranolol and four derivatives was examined by free solution capillary electrophoresis (FSCE) using various cyclodextrin molecules. Of the three modified cyclodextrins investigated, hydroxyethyl-β-cyclodextrin provided th
Autor:
Andrew G. Mills, T.M. Jefferies
Publikováno v:
Journal of Chromatography A. 643:409-418
The extraction and isolation of polychlorinated biphenyls (PCBs) from sample matrices such as freeze-dried milk is a lengthy and expensive process that conventionally requires the isolation of microgram amounts of PCBs from large volumes of flammable
Autor:
Andrew D. Cooper, T.M. Jefferies
Publikováno v:
Journal of Chromatography A. 637:137-143
The semi-preparative reversed-phase HPLC separation of brompheniramine enantiomers using β-cyclodextrin as a chiral mobile phase additive is described. Enantiomers were recovered free from mobile phase components on-line by a novel column switching