Phase 2 study of the Exportin 1 inhibitor selinexor in patients with recurrent gynecological malignancies

Autor: Y. Chai, S. Shacham, E Van Nieuwenhuysen, T.J. Unger, Anne L Kranich, T. Nottrup, Y. Landesman, Mansoor Raza Mirza, Morten Mau-Sørensen, Sileny Han, Charlotte Aaquist Haslund, Bente Lund, M. Kauffman, Ignace Vergote, J. Shah, A. Joshi, Marsha Crochiere, Nicole Concin, Tami Rashal, N. Au, Ulla Peen, Z. Umajuridze

Publikováno v: Vergote, I B, Lund, B, Peen, U, Umajuridze, Z, Mau-Sorensen, M, Kranich, A, Van Nieuwenhuysen, E, Haslund, C, Nottrup, T, Han, S N, Concin, N, Unger, T J, Chai, Y, Au, N, Rashal, T, Joshi, A, Crochiere, M, Landesman, Y, Shah, J, Shacham, S, Kauffman, M & Mirza, M R 2020, ' Phase 2 study of the Exportin 1 inhibitor selinexor in patients with recurrent gynecological malignancies ', Gynecologic Oncology, vol. 156, no. 2, pp. 308-314 . https://doi.org/10.1016/j.ygyno.2019.11.012

Background Selinexor is an oral inhibitor of the nuclear export protein Exportin 1 (XPO1) with demonstrated antitumor activity in solid and hematological malignancies. We evaluated the efficacy and safety of selinexor in heavily pretreated, recurrent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ff81ff5dfac1dd3abbd6fdb8002dcb
https://doi.org/10.1016/j.ygyno.2019.11.012

Examination of behavioral deficits triggered by targeting BDNF in fetal or postnatal brains of mice

Autor: Jason P. Chan, T.J. Unger, Maribel Rios, J. Byrnes

Publikováno v: Neuroscience. 142:49-58

Human and animal studies have implicated brain-derived neurotrophic factor (BDNF) in the etiology of psychiatric disorders. It is expressed in limbic regions of the brain associated with the regulation of emotionality during fetal development and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3340d715c6c698ae1238b71ab5faaeb5
https://doi.org/10.1016/j.neuroscience.2006.06.002

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