Plasmodium falciparum synthetic LbL microparticle vaccine elicits protective neutralizing antibody and parasite-specific cellular immune responses

Autor: T.J. Powell, James Gorham Boyd, Mary DeRome, Edwin Cardenas, Elizabeth Nardin, Andrea Jacobs, Robert Mitchell, Jie Tang, Naveen Palath, Yanhong Deng

Publikováno v: Vaccine. 31:1898-1904

Epitopes of the circumsporozoite (CS) protein of Plasmodium falciparum, the most pathogenic species of the malaria parasite, have been shown to elicit protective immunity in experimental animals and human volunteers. The mechanisms of immunity includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21a12a91ebf1e68f9e3f97a3753e2b2
https://doi.org/10.1016/j.vaccine.2013.02.027

A West Nile Virus Recombinant Protein Vaccine That Coactivates Innate and Adaptive Immunity

Autor: James W. Huleatt, Duane D. Hewitt, Erol Fikrig, Yan Huang, Jie Tang, Mcdonald William F, Andrea Jacobs, Lena Alexopoulou, Virginia N Takahashi, Valerian Nakaar, Harald G. Foellmer, T.J. Powell, Albert E. Price, Priyanka Desai

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2007, 195 (11), pp.1607-17. ⟨10.1086/517613⟩
Journal of Infectious Diseases, 2007, 195 (11), pp.1607-17. ⟨10.1086/517613⟩

A chimeric protein West Nile virus (WNV) vaccine capable of delivering both innate and adaptive immune signals was designed by fusing a modified version of bacterial flagellin (STF2 Delta ) to the EIII domain of the WNV envelope protein. This fusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7dff4e3e235f7a6ceec6504862b6b2
https://doi.org/10.1086/517613

Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors

Autor: Laura K. Shawver, B. Narog, C. Tang, Z. Harzstark, R. Levitzki, Alexander Levitzki, H. Ben-Bassat, Aviv Gazit, B.Y. Klein, J. Mccollough, H. Chen, T.J. Powell, J. Mcmahon, N. Shenoy, M. Chaouat

Publikováno v: British Journal of Dermatology. 141:802-810

Psoriasis is characterized by hyperproliferation of keratinocytes associated with an inflammatory infiltrate in the epidermis. Among factors which may be related to hyperplasia of psoriatic keratinocytes is the persistent autocrine stimulation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bc71e08559529dbc468b77a74549b5
https://doi.org/10.1046/j.1365-2133.1999.03152.x

Synthetic nanoparticle vaccines produced by layer-by-layer assembly of artificial biofilms induce potent protective T-cell and antibody responses in vivo

Autor: Naveen Palath, Andrea Jacobs, Jie Tang, T.J. Powell, Mary DeRome, James Gorham Boyd

Publikováno v: Vaccine. 29(3)

Nanoparticle vaccines induce potent immune responses in the absence of conventional adjuvant due to the recognition by immune cells of the particle structures, which mimic natural pathogens such as viruses and bacteria. Nanoparticle vaccines were fab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cd17d07795efc61214ec8d02b2799f
https://pubmed.ncbi.nlm.nih.gov/20951665

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

Autor: Scott Umlauf, Andrea Jacobs, Robert K. Evans, Lynda Tussey, Jie Tang, James W. Huleatt, Duane D. Hewitt, T.J. Powell, William F. Mcdonald, Yan Huang, Valerian Nakaar, Langzhou Song, Priyanka Desai

Publikováno v: Vaccine. 26(2)

The recognition of specific pathogen associated molecular patterns (PAMPs) by members of the Toll-like receptor (TLR) family is critical for the activation of the adaptive immune response. Thus, incorporation of PAMPs into vaccines should result in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ba7bc867e470df4c9bd512745b71ac
https://pubmed.ncbi.nlm.nih.gov/18063235