Examining individual- versus population-level social determinants of health in a cluster randomized trial of health coaches for patients with multiple chronic conditions

Autor: Mary E. Charlson, Martin T. Wells, James Hollenberg, Rosio Ramos, Guillerma Maritza Martinez, Martin J. Gerard, Andrea Cassells, T.J. Lin, Ilana Mittleman, Alice Eggleston, Jonathan N. Tobin

Publikováno v: Journal of Clinical and Translational Science, Vol 8 (2024)

Abstract Introduction: Social determinants of health (SDOH) are an important contributor to health status and health outcomes. In this analysis, we compare SDOH measured both at the individual and population levels in patients with high comorbidity

Externí odkaz: https://doaj.org/article/ffe21fa8c0f84b5485d80a76a070789b

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Esophageal Hypervigilance and Visceral Anxiety Are Contributors to Symptom Severity Among Patients Evaluated With High-Resolution Esophageal Manometry

Autor: Peter J. Kahrilas, François Mion, Laurie Keefer, Michael D. Crowell, Dustin A. Carlson, John E. Pandolfino, Jacqueline Prescott, Joseph Triggs, Farhan Quader, Dario Biasutto, C. Prakash Gyawali, Frederick T.J. Lin, Marcelo F. Vela, Tiffany H. Taft, Karthik Ravi, Sabine Roman

Publikováno v: Am J Gastroenterol

OBJECTIVES Symptoms are inconsistently associated with esophageal motor findings on high-resolution manometry (HRM). We aimed to evaluate predictors of dysphagia severity, including esophageal hypervigilance and visceral anxiety, among patients evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c117c151db06a8c41e3b68c758b1f75
https://doi.org/10.14309/ajg.0000000000000536

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Autor: Maria Carolina Borges, M. Geoffrey Hayes, Ke Hao, Carol A. Wang, Marjo-Riitta Järvelin, Niina Pitkänen, Ilkka Kalliala, Mariona Bustamante, Olli T. Raitakari, Bridget A. Knight, Robin N Beaumont, Matthew T. Weirauch, Line Skotte, Matthias Wielscher, Mark I. McCarthy, Klaus Bønnelykke, Vincent W. V. Jaddoe, Elina Hyppönen, Ole Mors, Tarunveer S. Ahluwalia, Thomas Werge, Frank Geller, Jonathan P. Bradfield, Vivek Appadurai, Kristin Skogstrand, Merete Nordentoft, Suzanne Vogelezang, Preben Bo Mortensen, Xueping Liu, Daniel Miller, Hakon Hakonarson, João Fadista, Pål R. Njølstad, Leah C. Kottyan, Wesley K. Thompson, Bruce Bedell, Katja Pahkala, Stefan Johansson, Dorte Helenius, Louis J. Muglia, Janine F. Felix, Rachel M. Freathy, Heather A. Boyd, Bjarke Feenstra, Ge Zhang, Anubha Mahajan, Alfonso Buil, Bo Jacobsson, Martine Vrijheid, Frederick T.J. Lin, William L. Lowe, Mads Melbye, Ron Nudel, Denise M. Scholtens, Julius Juodakis, Shouneng Peng, Christine Power, Andrew J. Schork, Jeffrey C. Murray, David M. Hougaard, Craig E. Pennell, Øyvind Helgeland, Struan F.A. Grant, Kelli K. Ryckman, Mary L. Marazita, Xiaoting Chen, Jonas Bacelis, Anders D. Børglum, Debbie A Lawlor, Hans Bisgaard, Robert M. Rossi, Fernando Rivadeneira, Leo-Pekka Lyytikäinen, Rebecca K. Vinding

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Liu, X, Helenius, D, Skotte, L, Beaumont, R N, Wielscher, M, Geller, F, Juodakis, J, Mahajan, A, Bradfield, J P, Lin, F T J, Vogelezang, S, Bustamante, M, Ahluwalia, T S, Pitkänen, N, Wang, C A, Bacelis, J, Borges, M C, Zhang, G, Bedell, B A, Rossi, R M, Skogstrand, K, Peng, S, Thompson, W K, Appadurai, V, Lawlor, D A, Kalliala, I, Power, C, McCarthy, M I, Boyd, H A, Marazita, M L, Hakonarson, H, Hayes, M G, Scholtens, D M, Rivadeneira, F, Jaddoe, V W V, Vinding, R K, Bisgaard, H, Knight, B A, Pahkala, K, Raitakari, O, Helgeland, Ø, Johansson, S, Njølstad, P R, Fadista, J, Schork, A J, Nudel, R, Miller, D E, Chen, X, Weirauch, M T, Mortensen, P B, Børglum, A D, Nordentoft, M, Mors, O, Hao, K, Ryckman, K K, Hougaard, D M, Kottyan, L C, Pennell, C E, Lyytikainen, L-P, Bønnelykke, K, Vrijheid, M, Felix, J F, Lowe, W L, Grant, S F A, Hyppönen, E, Jacobsson, B, Jarvelin, M-R, Muglia, L J, Murray, J C, Freathy, R M, Werge, T M, Melbye, M, Buil, A & Feenstra, B 2019, ' Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration ', Nature Communications, vol. 10, no. 1, 3927 . https://doi.org/10.1038/s41467-019-11881-8
Nature communications, vol 10, iss 1
Nature Communications
Liu, X, Helenius, D, Skotte, L, Beaumont, R N, Wielscher, M, Geller, F, Juodakis, J, Mahajan, A, Bradfield, J P, Lin, F T J, Vogelezang, S, Bustamante, M, Ahluwalia, T S, Pitkänen, N, Wang, C A, Bacelis, J, Borges, M C, Zhang, G, Bedell, B A, Rossi, R M, Skogstrand, K, Peng, S, Thompson, W K, Appadurai, V, Lawlor, D A, Kalliala, I, Power, C, McCarthy, M I, Boyd, H A, Marazita, M L, Hakonarson, H, Hayes, M G, Scholtens, D M, Rivadeneira, F, Jaddoe, V W V, Vinding, R K, Bisgaard, H, Knight, B A, Pahkala, K, Raitakari, O, Helgeland, Ø, Johansson, S, Njølstad, P R, Fadista, J, Schork, A J, Nudel, R, Miller, D E, Chen, X, Weirauch, M T, Mortensen, P B, Børglum, A D, Nordentoft, M, Mors, O, Hao, K, Ryckman, K K, Hougaard, D M, Kottyan, L C, Pennell, C E, Lyytikainen, L-P, Bønnelykke, K, Vrijheid, M, Felix, J F, Lowe, W L, Grant, S F A, Hyppönen, E, Jacobsson, B, Jarvelin, M-R, Muglia, L J, Murray, J C, Freathy, R M, Werge, T M, Melbye, M, Buil, A & Feenstra, B 2019, ' Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration ', Nature Communications, vol. 10, 3927 (2019) . https://doi.org/10.1038/s41467-019-11881-8
Nature Communications, 10:3927. Nature Publishing Group
Liu, X, Helenius, D, Skotte, L, Beaumont, R N, Wielscher, M, Geller, F, Juodakis, J, Mahajan, A, Bradfield, J P, Lin, F T J, Vogelezang, S, Bustamante, M, Ahluwalia, T S, Pitkänen, N, Wang, C A, Bacelis, J, Borges, M C, Zhang, G, Bedell, B A, Rossi, R M, Skogstrand, K, Peng, S, Thompson, W K, Appadurai, V, Lawlor, D A, Kalliala, I, Power, C, McCarthy, M I, Boyd, H A, Marazita, M L, Hakonarson, H, Hayes, M G, Scholtens, D M, Rivadeneira, F, Jaddoe, V W V, Vinding, R K, Bisgaard, H, Knight, B A, Pahkala, K, Raitakari, O, Helgeland, Ø, Johansson, S, Njølstad, P R, Fadista, J, Schork, A J, Nudel, R, Mortensen, P B, Børglum, A D, Mors, O & Jacobsson, B 2019, ' Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration ', Nature Communications, vol. 10, no. 1, 3927, pp. 1-13 . https://doi.org/10.1038/s41467-019-11881-8

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdce669ac365fdce646e8f4934aa82cb
https://doaj.org/article/0663e700e52e44dd96778ff7a9670192

Multi-ancestry Genome- and Phenome-wide Association Studies of Diverticular Disease in Electronic Health Records with Natural Language Processing enriched phenotype algorithm

Autor: Omri Gottesman, Frederick T.J. Lin, James G. Linneman, Mariza de Andrade, Luke V. Rasmussen, Rex L. Chisholm, Joshua C. Denny, Annapoorani Veerappan, Gerard Tromp, Laura J. Rasmussen-Torvik, Kenneth M. Borthwick, Andrew Cagan, Peggy L. Peissig, Jyotishman Pathak, M. Geoffrey Hayes, Ning Shang Shang, Erwin P. Bottinger, William K. Thompson, Jennifer A. Pacheco, Stephen B. Ellis, Andrew J. Gawron, Maureen E. Smith, Yoonjung Yoonie Joo, David Carrell, Abel N. Kho

Background and aimsDiverticular disease is among the most prevalent conditions encountered by gastroenterologists, affecting ∼50% of Americans before the age of 60. Our aim was to identify genetic risk variants and clinical phenotypes associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e08c4c98f1159a3e13441ba2cf0f8b08
https://doi.org/10.1101/2020.06.08.138735