Zobrazeno 1 - 1
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pro vyhledávání: '"T.G. Dhar"'
Autor:
Jingwu Duan, Hai-Yun Xiao, Steven G. Nadler, Kim W. McIntyre, Michael Galella, Bin Jiang, Zili Xiao, Julie Carman, Sium Habte, Luisa Salter-Cid, Mark D. Cunningham, T.G. Dhar, Deborah A. Holloway, Jinhong Wang, David J. Shuster, John E. Somerville, David S. Weinstein, Michael G. Yang, Joel C. Barrish
Publikováno v:
Journal of Medicinal Chemistry. 58:4278-4290
An empirical approach to improve the microsomal stability and CYP inhibition profile of lead compounds 1a and 1b led to the identification of 5 (BMS-341) as a dissociated glucocorticoid receptor modulator. Compound 5 showed significant improvements i