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pro vyhledávání: '"T.Daniel Griffiths"'
Publikováno v:
Mutation Research/DNA Repair. 255:257-264
The relative importance of the UV-induced pyrimidine(5-6)pyrimidine and the pyrimidine(6-4)-pyrimidone lesions in sister-chromatid exchanges (SCEs), activation of alternative sites of replicon initiation and thymidine incorporation were examined usin
Publikováno v:
Cancer letters. 105(2)
Previous work by many groups has documented induction of the human immunodeficiency virus (HIV) long terminal repeat (LTR) following exposure of cells to ultraviolet light and other DNA damaging agents. Our experiments set out to determine the relati
Autor:
Su Y. Ling, T.Daniel Griffiths
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 826:121-128
Wild-type Chinese hamster ovary cells (AA8) and five excision-deficient clones derived from the AA8 line (UV-4, UV-5, UV-20, UV-24 and UV-41) were exposed to ultraviolet light and then analyzed for their ability to incorporate [3H]thymidine and to in
Autor:
Su Y. Ling, T.Daniel Griffiths
Publikováno v:
Mutation Research/DNA Repair. 218:87-94
Exposure of mammalian cells to 254 nm UV light produces lesions that block DNA polymerases at least on the leading strand. For rodent cells the extent and duration of this blockage is both cell line- and fluence-dependent. Using DNA fiber autoradiogr
Publikováno v:
Mechanisms of Ageing and Development. 21:15-25
The rate of incorporation of deoxythymidine triphosphate (dTTP) into acid-precipitable material of permeabilized MRC-5 and WI-38 cells as well as the rate of DNA chain growth in both intact and permeabilized cells was examined as a function of cell a
Autor:
T.Daniel Griffiths, Su Y. Ling
Publikováno v:
Mutation Research/DNA Repair Reports. 184:39-46
Exposure to UV light is known to produce lesions that block DNA polymerases at least on the leading strand. If several lesions are present in adjacent replicons, it is likely that sections of DNA would remain unreplicated because of the presence for
Autor:
T.Daniel Griffiths
Publikováno v:
Mechanisms of ageing and development. 24(3)
The minimum time it takes a cell to pass completely through the S phase (MIN S) was examined in human diploid fibroblasts using a sequential [ 14 C]thymidine, [ 3 H]thymidine, [ 14 C]thymidine labeling protocol. MIN S appeared to be around 6–8 h fo
Autor:
T.Daniel Griffiths, Su Y. Ling
Publikováno v:
Biochemical and biophysical research communications. 123(2)
It has been reported that changes in deoxynucleotide pool levels following exposure to UV might lead to an overestimation of the UV-induced depression in DNA synthesis as analyzed by incorporation of 3H-thymidine (1). We attempted to determine the im