BuGZ exhibits guanine nucleotide exchange factor activity toward tubulin

Autor: Wesley J. Yon, Joseph R. Tran, Taekjip Ha, Yixian Zheng, Ross T.A. Pedersen

α- and β-tubulin form heterodimers, with GTPase activity, that assemble into microtubules. Like other GTPases, the nucleotide-bound state of tubulin heterodimers controls whether the molecules are in a biologically active or inactive state. While �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca57f076e4f9b784a03035c5447a986
https://doi.org/10.1101/2023.05.09.539990

A preferred sequence for organelle inheritance during polarized cell growth

Autor: David G. Drubin, Ross T.A. Pedersen, Michelle S. Lu, Kathryn W Li, Yuichiro Iwamoto

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

Some organelles cannot be synthesized anew, so they are segregated into daughter cells during cell division. In Saccharomyces cerevisiae, daughter cells bud from mother cells and are populated by organelles inherited from the mothers. To determine wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d9fc6e6860705fc73d5a8f970eac97
https://pubmed.ncbi.nlm.nih.gov/34622919

Spatial regulation of clathrin-mediated endocytosis through position-dependent site maturation

Autor: David G. Drubin, Ross T.A. Pedersen, Julian Hassinger, Paul Marchando

Publikováno v: The Journal of cell biology, vol 219, iss 11
The Journal of Cell Biology

Pedersen et al. investigate steps of the clathrin-mediated endocytosis pathway that are subject to regulation. They report position-dependent differences in endocytic site maturation rates in polarized cells and suggest that cargo controls endocytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6dfe06d44326cc54dedc70b5a9f39a
https://escholarship.org/uc/item/07r626gx

Type I myosins anchor actin assembly to the plasma membrane during clathrin-mediated endocytosis

Autor: David G. Drubin, Ross T.A. Pedersen

Publikováno v: The Journal of Cell Biology
The Journal of cell biology, vol 218, iss 4

Actin assembly and type I myosins are both required for clathrin-mediated endocytosis. Here Pedersen and Drubin show that type I myosins anchor actin assembly factors to the plasma membrane at sites of clathrin-mediated endocytosis, facilitating forc

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https://pubmed.ncbi.nlm.nih.gov/30659101

TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae

Autor: Ross T.A. Pedersen, Jeffrey Liu, Kristin L. Leskoske, Jeremy Thorner, Françoise M. Roelants, Gregory C. Finnigan, Alexander Muir

Publikováno v: Molecular and cellular biology, vol 37, iss 7
Roelants, FM; Leskoske, KL; Pedersen, RTA; Muir, A; Liu, JMH; Finnigan, GC; et al.(2017). TOR complex 2-regulated protein kinase Fpk1 stimulates endocytosis via inhibition of Ark1/Prk1-related protein kinase Akl1 in Saccharomyces cerevisiae. Molecular and Cellular Biology, 37(7). doi: 10.1128/MCB.00627-16. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5422n6bh
Molecular and Cellular Biology

© 2017 Roelants et al. Depending on the stress, plasma membrane alterations activate or inhibit yeast target of rapamycin (TOR) complex 2, which, in turn, upregulates or downregulates the activity of its essential downstream effector, protein kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78367d2189990f2c82cc0586c5d1ac74
https://escholarship.org/uc/item/5422n6bh