Zobrazeno 1 - 10
of 20
pro vyhledávání: '"T.A. Panchal"'
Autor:
S. P. Watson, A.U. Butt, J.M.S. Paton, A.W. Dean, Martin Pass, G.S. Currie, T. Hubbard, M.C. Donnelly, K.S. Cardwell, Torquil I. Jack, David Middlemiss, M.K. Bayliss, N.M. Aston, Duncan B. Judd, Nicola Murdoch Heron, D.G. Allen, T.A. Panchal, A. Hilditch, D. Gallacher, J.E. Hobson, G.M. Drew
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:725-728
The identification of a series of imidazopyridinylbenzofurans (1) as potent, non-peptide antogonists of angiotensin II is described. Several of these compounds cause marked falls in blood pressure in the renal artery ligated rat model of hypertension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::400a384a545a03eab7bb4d5dd9f3d76a
https://doi.org/10.1016/s0960-894x(01)80188-8
https://doi.org/10.1016/s0960-894x(01)80188-8
Autor:
G.M. Drew, A. Travers, B.C. Ross, T.A. Panchal, E. Palmer, Steve P. Watson, A. Hilditch, David Middlemiss, J.G. Montana, M.J. Robertson, A.A.E. Hunt, G.R.M. Manchee, G.C. Hirst, J.M.S. Paton, T. Hubbard, David I. C. Scopes, G. Stuart, M.D. Dowle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2043-2046
A series of GR117289 derived amino acid-amide angiotensin II antagonists is described. The possibility that the amino acid-amide element of these molecules mimics the C-terminus of Angiotensin II is discounted. One of these compounds, (2g), exhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49036050cc030106b1f6c893bf2e68e
https://doi.org/10.1016/s0960-894x(01)81011-8
https://doi.org/10.1016/s0960-894x(01)81011-8
Autor:
Martin Pass, M.C. Donnelly, D.I.C. Scopes, Barry Clive Ross, G.R. Manchee, Kenneth L. Clark, T.A. Panchal, A. A. E. Hunt, David Middlemiss, M.K. Bayliss, J.E. Hobson, M.D. Dowle, A. Travers, G.M. Drew, D.G. Walker, Duncan B. Judd, Torquil I. Jack, P.G. Stuart, E. Tranquillini, A. Hilditch, M.J. Robertson, P.J. Eddershaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2047-2050
The identification of GR138950, a non-peptide antagonist of angiotensin II with high oral bioavailability, is described. GR138950 is a potent and selective AT 1 receptor antagonist which causes marked falls in blood pressure in renal hypertensive rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e99e888e2125cc4f66113c17665aace4
https://doi.org/10.1016/s0960-894x(01)81012-x
https://doi.org/10.1016/s0960-894x(01)81012-x
Autor:
Kenneth Lyle Clark, Steven J Coote, K.S. Cardwell, J.G. Montana, Steve P. Watson, G.C. Hirst, G.R.M. Manchee, J. Hamblett, M.J. Robertson, David Middlemiss, M. Donnelly, B.C. Ross, T.A. Panchal, E. Palmer, J.M.S. Paton, A. Hilditch, G.M. Drew, David I. C. Scopes, M. Pass, M.D. Dowle, J. Bradshaw, Torquil I. Jack, T. Hubbard, M.K. Bayliss, G. Stuart, P. Shah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:589-594
A study of structure activity relationships based on the bromobenzofuran angiotensin II antagonist GR117289 is reported. This study led to the identification of compounds with potency in vitro enhanced by ca. 10 fold. Also reported is the enhancement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbaea88e6d2f5f5513c4ccd3cdac2b65
https://doi.org/10.1016/s0960-894x(01)81235-x
https://doi.org/10.1016/s0960-894x(01)81235-x
Autor:
A. Butt, Steve P. Watson, Martin Pass, J.M.S. Paton, T. Hubbard, M.K. Bayliss, M. Donnelly, David Middlemiss, T.A. Panchal, Nicola Murdoch Heron, A. W. Dean
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4f72c155018b18488dd134e85239f19
https://doi.org/10.1002/chin.199426163
https://doi.org/10.1002/chin.199426163
Autor:
B.C. Ross, T. Hubbard, David Middlemiss, A. Hilditch, Kenneth Lyle Clark, T.A. Panchal, Colin David Eldred, P. Shah, Steve P. Watson, M.J. Robertson, J.G. Montana, G.C. Hirst, J.M.S. Paton, G.M. Drew
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1243-1246
The identification of a novel series of C-linked pyrazole biaryl tetrazole antagonists of angiotensin II is described. These compounds are highly potent in vitro (pKB ca . 10) and some examples cause significant reductions in blood pressure at 1mgkg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac7fa5f5e3e5ef1054f0fa64141db92b
https://doi.org/10.1016/s0960-894x(00)80222-x
https://doi.org/10.1016/s0960-894x(00)80222-x
Autor:
J Akers, D.I.C. Scopes, M.D. Dowle, Steven John Coote, P. Shah, J Hamblett, C.D. Eldred, Barry Clive Ross, M. J. Robertson, J.M.S. Paton, T.A. Panchal, G.M. Drew, G Stuart, K. L. Clark, A. Hilditch, A. Travers, Torquil I. Jack, K.S. Cardwell, G.C. Hirst, John Gary Montana, David Middlemiss
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:711-716
This paper describes the synthesis and pharmacology of a novel series of benzofurans which are antagonists of angiotensin II. One of these, the bromobenzofuran 11b, is a potent (apparent pKB=9.8) and specific antagonist of angiotensin II which, after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55219f2de81f8548b7ffa26c3216bf4b
https://doi.org/10.1016/s0960-894x(01)81053-2
https://doi.org/10.1016/s0960-894x(01)81053-2
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