Zobrazeno 1 - 10
of 1 124
pro vyhledávání: '"T.-S. Lin"'
Publikováno v:
Earth System Dynamics, Vol 11, Pp 641-652 (2020)
Spring wheat is a major food crop that is a staple for a large number of people in India and the world. To address the issue of food security, it is essential to understand how the productivity of spring wheat varies with changes in environmental con
Externí odkaz:
https://doaj.org/article/7cacdc1f40b14378acd16add33e3d9bb
Autor:
Ola E. Salama, Nikho Hizon, Melissa Del Vecchio, Kurt Kolsun, Mario A. Fonseca, David T. S. Lin, Oscar Urtatiz, Julia L. MacIsaac, Michael S. Kobor, Elizabeth A. C. Sellers, Vernon W. Dolinsky, Allison B. Dart, Meaghan J. Jones, Brandy A. Wicklow
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Objective Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is known to be a specific ris
Externí odkaz:
https://doaj.org/article/7bffa8c1e7684ef8bb5927a17a02682a
Autor:
Jacob Bergstedt, Sadoune Ait Kaci Azzou, Kristin Tsuo, Anthony Jaquaniello, Alejandra Urrutia, Maxime Rotival, David T. S. Lin, Julia L. MacIsaac, Michael S. Kobor, Matthew L. Albert, Darragh Duffy, Etienne Patin, Lluís Quintana-Murci, Milieu Intérieur Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Many studies assess epigenetic marks in white blood cells, but it is unclear how much immune factors affect the epigenome. Here, the authors show that fine-scale blood cell composition and cytomegalovirus infection affect the DNA methylome of adults.
Externí odkaz:
https://doaj.org/article/d485673d79fb4ce58ac6fd1885bfaa9c
Autor:
Hannah-Ruth Engelbrecht, Sarah M. Merrill, Nicole Gladish, Julie L. MacIsaac, David T. S. Lin, Simone Ecker, Christina A. Chrysohoou, Giovanni M. Pes, Michael S. Kobor, David H. Rehkopf
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Sex differences in aging manifest in disparities in disease prevalence, physical health, and lifespan, where women tend to have greater longevity relative to men. However, in the Mediterranean Blue Zones of Sardinia (Italy) and Ikaria (Greece) are re
Externí odkaz:
https://doaj.org/article/15b9d68d619542e4acf27dbb31cebca9
Autor:
Nastassja Koen, Meaghan J. Jones, Raymond T. Nhapi, Marilyn T. Lake, Kirsten A. Donald, Whitney Barnett, Nadia Hoffman, Julia L. MacIsaac, Alexander M. Morin, David T. S. Lin, Michael S. Kobor, Karestan C. Koenen, Heather J. Zar, Dan J. Stein
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Accelerated epigenetic aging relative to chronological age has been found to be associated with higher risk of mortality in adults. However, little is known about whether and how in utero exposures might shape child gestational epigenetic ag
Externí odkaz:
https://doaj.org/article/a8ae39c8f71c452b97cf529514b1fc44
Autor:
Nathan Rabinovitch, Meaghan J. Jones, Nicole Gladish, Anna V. Faino, Matthew Strand, Alexander M. Morin, Julie MacIsaac, David T. S. Lin, Paul R. Reynolds, Amrit Singh, Erwin W. Gelfand, Michael S. Kobor, Christopher Carlsten
Publikováno v:
Epigenetics, Vol 16, Iss 2, Pp 177-185 (2021)
Air pollution is associated with early declines in lung function and increased levels of asthma-related cysteinyl leukotrienes (CysLT) but a biological pathway linking this rapid response has not been delineated. In this randomized controlled diesel
Externí odkaz:
https://doaj.org/article/de69246eb7144191a962e43961d0a1b0
Autor:
Ana I. Hernandez Cordero, Chen Xi Yang, Xuan Li, Julia Yang, Tawimas Shaipanich, Julie L. MacIsaac, David T. S. Lin, Michael S. Kobor, Steve Horvath, Shu Fan Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3094 (2022)
One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose
Externí odkaz:
https://doaj.org/article/84f73eb940484d68bd8759df675c679c
Autor:
Darina Czamara, Gökçen Eraslan, Christian M. Page, Jari Lahti, Marius Lahti-Pulkkinen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M. Villa, Rebecca M. Reynolds, Wenche Nystad, Siri E. Håberg, Stephanie J. London, Kieran J. O’Donnell, Elika Garg, Michael J. Meaney, Sonja Entringer, Pathik D. Wadhwa, Claudia Buss, Meaghan J. Jones, David T. S. Lin, Julie L. MacIsaac, Michael S. Kobor, Nastassja Koen, Heather J. Zar, Karestan C. Koenen, Shareefa Dalvie, Dan J. Stein, Ivan Kondofersky, Nikola S. Müller, Fabian J. Theis, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Katri Räikkönen, Elisabeth B. Binder
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects
Externí odkaz:
https://doaj.org/article/c16c2e7cc35f40888a47624f500c9455
Autor:
R. Waziry, C. P. Ryan, D. L. Corcoran, K. M. Huffman, M. S. Kobor, M. Kothari, G. H. Graf, V. B. Kraus, W. E. Kraus, D. T. S. Lin, C. F. Pieper, M. E. Ramaker, M. Bhapkar, S. K. Das, L. Ferrucci, W. J. Hastings, M. Kebbe, D. C. Parker, S. B. Racette, I. Shalev, B. Schilling, D. W. Belsky
Publikováno v:
Nature Aging. 3:248-257
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1–3. Caloric restriction (CR), defined as lessening caloric intake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9fc145035a1ff44bee8d283ac3ca9b6
https://doi.org/10.1038/s43587-022-00357-y
https://doi.org/10.1038/s43587-022-00357-y
Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis
Autor:
Megan E Ramaker, David L Corcoran, Abner T Apsley, Michael S Kobor, Virginia B Kraus, William E Kraus, David T S Lin, Melissa C Orenduff, Carl F Pieper, Reem Waziry, Kim M Huffman, Daniel W Belsky
Publikováno v:
The Journals of Gerontology: Series A. 77:2395-2401
Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes in animal models. In the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CAL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def3a40ac5500c0506b8a0ff132151ce
https://doi.org/10.1093/gerona/glac168
https://doi.org/10.1093/gerona/glac168