Zobrazeno 1 - 10
of 1 185
pro vyhledávání: '"T. cruzi"'
Autor:
Alcives Avila-Sorrosa, Diana J. Laurel-Gochicoa, María Elena Vargas-Díaz, Benjamín Nogueda-Torres, Rogelio I. Gómez-Escobedo
Publikováno v:
Chemistry, Vol 6, Iss 5, Pp 1201-1216 (2024)
Chalcones are organic structures that occur naturally in flavonoids and isoflavonoids from diverse vegetables and fruits. Their properties have promising applications in medicinal chemistry as antiparasitic agents against malaria, leishmaniasis, and
Externí odkaz:
https://doaj.org/article/7b4604e737844fc1922b46a554bdd1c2
Autor:
Evandro R. Dias, Andressa M. Durans, Barbara B. Succar, Luiz André L. T. Pinto, Guilherme C. Lechuga, Mariana G. Miguez, Janaina Figueira-Mansur, Ana P. C. Argondizzo, Aline R. Bernardo, Rafaela L. Diniz, Gabriela S. Esteves, Edimilson D. Silva, Carlos M. Morel, José Borges-Pereira, Salvatore G. De-Simone, Angela C. V. Junqueira, David William Provance
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9811 (2024)
We developed a protein to rapidly and accurately diagnose Chagas disease, a life-threatening illness identified by the WHO as a critical worldwide public health risk. Limitations in present day serological tests are complicating the current health si
Externí odkaz:
https://doaj.org/article/84502c94eb554ac1b3b8492314b78fd5
Autor:
Norma Bautista-Lopez, Momar Ndao
Publikováno v:
Frontiers in Parasitology, Vol 3 (2024)
The Polymerase Chain Reaction (PCR) test is a highly sensitive, specific, and rapid diagnostic tool for Chagas disease. Chagas disease is caused by the protozoan flagellate Trypanosoma cruzi and is endemic to the Americas. While conventional serologi
Externí odkaz:
https://doaj.org/article/5430043a020e413182e1e7ba4d32adee
Autor:
Ali Mijoba, Nereida Parra-Giménez, Esteban Fernandez-Moreira, Hegira Ramírez, Xenón Serrano, Zuleima Blanco, Sandra Espinosa, Jaime E. Charris
Publikováno v:
Molecules, Vol 29, Iss 17, p 4125 (2024)
The aim of this work was to obtain and evaluate, as antiprotozoals, new derivatives of benzoate imidazo-1,3,4-thiadiazole 18–23 based on the concepts of molecular repositioning and hybridization. In the design of these compounds, two important phar
Externí odkaz:
https://doaj.org/article/4901eeef606e4e658bea1f27556d6878
Autor:
Víctor Alberto Maravelez Acosta, María del Pilar Crisóstomo Vázquez, Leticia Eligio García, Luz Ofelia Franco Sandoval, Denia Castro Pérez, Genaro Patiño López, Oscar Medina Contreras, Enedina Jiménez Cardoso
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8307 (2024)
Parasites have been associated with possible anticancer activity, including Trypanosoma cruzi, which has been linked to inhibiting the growth of solid tumors. To better understand this antitumor effect, we investigated the association of anti-T. cruz
Externí odkaz:
https://doaj.org/article/79eecb803e444f02817927d6a394c907
Autor:
Laura Fernanda Ambrosio, Ximena Volpini, Juan Nahuel Quiroz, María Belén Brugo, Carolina Paola Knubel, Melisa Rocío Herrera, Laura Fozzatti, Julián Avila Pacheco, Clary B. Clish, Maisa C. Takenaka, Juan Beloscar, Martín Gustavo Theumer, Francisco Javier Quintana, Ana Rosa Perez, Claudia Cristina Motrán
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionChagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic
Externí odkaz:
https://doaj.org/article/b34f100cf49d442c9e226c889090d1dc
Autor:
Bryan VanSchouwen, Giuseppe Melacini
Publikováno v:
eLife, Vol 12 (2023)
Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?
Externí odkaz:
https://doaj.org/article/fbd569bdb3274a82818d326612dbd468
Autor:
Amanda Faier-Pereira, Paula Finamore-Araujo, Carlos Ramon do Nascimento Brito, Eldrinei Gomes Peres, Klenicy Kazumy de Lima Yamaguchi, Daniele Pereira de Castro, Otacilio C. Moreira
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5531 (2024)
Currently, approximately 70% of new cases of Chagas disease (CD) in Brazil are attributed to oral transmission, particularly through foods such as açaí, bacaba, and sugarcane juice, primarily in the northern and northeastern regions of the country.
Externí odkaz:
https://doaj.org/article/8b27358d1ac6426d8a0e7bb1bba211d8
Autor:
Edio Maldonado, Paz Canobra, Matías Oyarce, Fabiola Urbina, Vicente J. Miralles, Julio C. Tapia, Christian Castillo, Aldo Solari
Publikováno v:
Microorganisms, Vol 12, Iss 5, p 907 (2024)
Chagas disease is caused by the single-flagellated protozoan Trypanosoma cruzi, which affects several million people worldwide. Understanding the signal transduction pathways involved in this parasite’s growth, adaptation, and differentiation is cr
Externí odkaz:
https://doaj.org/article/1505753e82db4edd9bed7ad3297d0f5e
Autor:
Luciana Benevides, Lais A. Sacramento, Franciele Pioto, Gabriel Dessotti Barretto, Vanessa Carregaro, João S. Silva
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In many infectious diseases, the pathogen-induced inflammatory response could result in protective immunity that should be regulated to prevent tissue damage and death. In fact, in Trypanosoma cruzi infection, the innate immune and the inflammatory r
Externí odkaz:
https://doaj.org/article/9f12902d63294486bf5e69e6b896d2f8