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Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Autor: Agnieszka Dansonka-Mieszkowska, Usha Menon, Melissa C. Southey, Diana Eccles, Robert Winqvist, Keitaro Matsuo, Matthias W. Beckmann, Robert A. Stephenson, Paul D.P. Pharoah, Lambertus A. Kiemeney, Elizabeth M. Poole, Paul Brennan, Wojciech Kluzniak, Liesel M. FitzGerald, Alice S. Whittemore, Kunle Odunsi, Mary Anne Rossing, Craig C. Teerlink, Javier Benitez, Arif B. Ekici, Thilo Dörk, Per Hall, C. Slavov, Matthieu Moisse, Jennifer B. Permuth, Hermann Brenner, Apcb BioResource, Julia A. Knight, Teuvo L.J. Tammela, Douglas A. Levine, Alicja Wolk, Sofia Maia, Kamila Czene, Vessela N. Kristensen, Radka Kaneva, Hoda Anton-Culver, Jonathan Tyrer, Manjeet K. Bolla, Maureen Sanderson, Fengju Song, Veli-Matti Kosma, Dieter Flesch-Janys, Douglas F. Easton, John L. Hopper, Marjanka K. Schmidt, Jolanta Kupryjanczyk, Amanda B. Spurdle, Nicolas Wentzensen, kConFab Investigators, Peter A. Fasching, Leon F.A.G. Massuger, Jonathan Beesley, Qin Wang, Pascal Guénel, Penelope M. Webb, Paolo Peterlongo, Daniel C. Tessier, Peter Kraft, Jennifer A. Doherty, Daehee Kang, Christine B. Ambrosone, Weiva Sieh, Anja Rudolph, Ignace Vergote, Hiltrud Brauch, Celeste Leigh Pearce, Robert N. Hoover, Paula Paulo, Nbcs Investigators, Rosalind A. Eeles, Honglin Song, Fergus J. Couch, Brian E. Henderson, Lisa A. Cannon-Albright, William J. Blot, Soo-Chin Lee, Abctb Investigators, Ute Hamann, Angela Cox, Peter Devilee, Andrzej M. Kierzek, Qiuyin Cai, Elinor J. Sawyer, Jacek Gronwald, Janet L. Stanford, Soo-Hwang Teo, Fredrick R. Schumacher, Montserrat Garcia-Closas, Susanne K. Kjaer, Christa Stegmaier, Thomas Brüning, Graham G. Giles, Catriona McLean, Thomas A. Sellers, Georgia Chenevix-Trench, Ellen L. Goode, Maartje J. Hooning, Kathleen Herkommer, Jenny L Donovan, Fiona Bruinsma, Minouk J. Schoemaker, Marc T. Goodman, Volker Arndt, Estrid Høgdall, Yu-Tang Gao, Ruth C. Travis, Claus Høgdall, Celine M. Vachon, Jan Lubinski, Qiyuan Li, Vanio Mitev, Argyrios Ziogas, Julie M. Cunningham, Ming-Feng Hou, Marjorie J. Riggan, David J. Hunter, T. Wahlfors, Michael Jones, Diether Lambrechts, Hui-Yi Lim, Stephen N. Thibodeau, Kenneth Offitt, Stig E. Bojesen, Kexin Chen, Harvey A. Risch, Fredrik Wiklund, Hans-Ulrich Ulmer, Natalia Bogdanova, Joellen M. Schildkraut, Kristiina Aittomäki, Helga B. Salvesen, Markus Aly, Hatef Darabi, Christopher A. Haiman, Shelley S. Tworoger, Zsofia Kote-Jarai, Judith A. Clements, Andrew Berchuck, Francesmary Modugno, Drakoulis Yannoukakos, Catherine M. Phelan, Julian Peto, Børge G. Nordestgaard, Simon A. Gayther, Barbara Burwinkel, Nazneen Rahman, Todd L. Edwards, Wei Zheng, Ralf Bützow, Siddhartha Kar, Manuel R. Teixeira, Anna H. Wu, Stephen J. Chanock, Kirsten B. Moysich, Per Broberg, Ana Peixoto, Sara Lindström, Daniel J. Schaid, Sonja I. Berndt, Dominika Wokozorczyk, Jonine D. Figueroa, Aida Karina Dieffenbach, Anna González-Neira, Reidun K. Kopperud, Jacques Simard, Alvaro N.A. Monteiro, David E. Neal, Tanja Pejovic, Florian Heitz, Beth Y. Karlan, Elza Khusnutdinova, Anthony J. Swerdlow, Joe Dennis, Veronica Wendy Setiawan, Heli Nevanlinna, Christiane Maier, Walther Vogel, Henrik Grönberg, Aleksandra Gentry-Maharaj, Kay-Tee Khaw, Jenny Chang-Claude, Carl Blomqvist, Susan M. Gapstur, Adam S. Kibel, Daniel W. Cramer, Manuel Luedeke, Robert J. MacInnis, Agnieszka Michael, Daniel O. Stram, Michelle A.T. Hildebrandt, Xiao-Ou Shu, Roberta B. Ness, Ian G. Campbell, Nora Pashayan, Timothy J. Key, Julio M. Pow-Sang, Hardev Pandha, Karen Lu, Elisa V. Bandera, Freddie C. Hamdy, Håkan Olsson, Sara H. Olson, Ali Amin Al Olama, Iain A. McNeish, Alison M. Dunning, Matthew L. Freedman, Kenneth Muir, Nhu D. Le, Linda S. Cook, Annika Lindblom, Sara Benlloch, Roger L. Milne, Kate Lawrenson, Digna R. Velez Edwards, Michael Lush, Hans Wildiers, Deborah J. Thompson, Susan J. Ramus, Kyriaki Michailidou, Rita K. Schmutzler, Nick Orr, Jyotsna Batra, Malcolm C. Pike, Cezary Cybulski, Shannon K. McDonnell, Jong Y. Park, Johanna Schleutker

Publikováno v: Cancer Discovery, 6, 1052-67
Cancer Discovery, 6, 9, pp. 1052-67
Kar, S P, Beesley, J, Al Olama, A A, Michailidou, K, Tyrer, J & Donovan, J 2016, ' Genome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by At Least Two Cancer Types ', Cancer Discovery, vol. 6, no. 9, pp. 1052-1067 . https://doi.org/10.1158/2159-8290.CD-15-1227
Cancer Discovery, 6(9), 1052-1067. American Association for Cancer Research Inc.
Kar, S P, Beesley, J, Amin Al Olama, A, Michailidou, K, Tyrer, J, Kote-Jarai, ZS, Lawrenson, K, Lindstrom, S, Ramus, S J, Thompson, D J, Kibel, A S, Dansonka-Mieszkowska, A, Michael, A, Dieffenbach, A K, Gentry-Maharaj, A, Whittemore, A S, Wolk, A, Monteiro, A, Peixoto, A, Kierzek, A, Cox, A, Rudolph, A, Gonzalez-Neira, A, Wu, A H, Lindblom, A, Swerdlow, A, Ziogas, A, Ekici, A B, Burwinkel, B, Karlan, B Y, Nordestgaard, B G, Blomqvist, C, Phelan, C, McLean, C, Pearce, C L, Vachon, C, Cybulski, C, Slavov, C, Stegmaier, C, Maier, C, Ambrosone, C B, Høgdall, C K, Teerlink, C C, Kang, D, Tessier, D C, Schaid, D J, Stram, D O, Cramer, D W & Neal, D E & Figueroa, J 2016, ' Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types ', Cancer Discovery . https://doi.org/10.1158/2159-8290.CD-15-1227
Kar, S P, Beesley, J, Amin Al Olama, A, Michailidou, K, Tyrer, J, Kote-Jarai, ZS, Lawrenson, K, Lindstrom, S, Ramus, S J & Orr, N 2016, ' Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types ', Cancer discovery, vol. 6, no. 9, pp. 1052-1067 . https://doi.org/10.1158/2159-8290.CD-15-1227
Cancer Discovery, 6(9), 1052-1067

Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9351b2339418e44950d96538f4ae0167
http://hdl.handle.net/2066/172624

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Autor: Cao G-W., Joanne L. Dickinson, Gianluca Severi, Tokhir Dadaev, Alan Horwich, S. Lindstrom, Sonja I. Berndt, Jong Y. Park, Shannon K. McDonnell, Lin H-Y., Amit Joshi, Daniel Leongamornlert, Johanna Schleutker, Robert Huddart, Zhang H-W., Ruth Frikke-Schmidt, Melissa C. Southey, Amanda B. Spurdle, Jan Adolfsson, Michael Gaziano, David G. Cox, Elio Riboli, Erika M. Kwon, Jyotsna Batra, K. Govindasami, Amanda L. Hall, Karina Dalsgaard Sørensen, S. Benlloch, E. Saunders, Vanio Mitev, Paula Kujala, Chris Ogden, Peter Kraft, Anssi Auvinen, S. J. Chanock, Vincent Khoo, Kathleen Herkommer, Michael Borre, C. Slavov, Rosalind A. Eeles, Heiko Müller, Lisa A. Cannon-Albright, D J Schaid, David E. Neal, Doug Easton, Tammela Tlj., W. R. Diver, E J Sawyer, Martin Andreas Røder, Afshan Siddiq, Jianfeng Xu, Michelle Guy, Andreas Meyer, Joanne F. Aitken, Shintaro Narita, Michael J. Thun, Malgorzata Tymrakiewicz, James R. Marthick, Torben F. Ørntoft, Lynne T. O'Brien, Edward Giovannucci, R A Wilkinson, Fredrick R. Schumacher, Mariana C. Stern, Zsofia Kote-Jarai, Antje E. Rinckleb, Ahva Shahabi, Jarmo Virtamo, T A Sellers, Christiane Maier, C.R.J. Woodhouse, Pedro Vaz Pinto, Sue A. Ingles, Cezary Cybulski, Jenny L Donovan, Anna M. Ray, Henrik Grönberg, Markus Aly, Kenneth Muir, Suzanne K. Chambers, Tim Dudderidge, Danielle M. Karyadi, Judith A. Clements, Briony Patterson, Susan M. Gapstur, Manuel Luedeke, Demetrius Albanes, Federico Canzian, B. E. Henderson, Elaine A. Ostrander, Thilo Dörk, John L. Hopper, Fredrik Wiklund, Lu Y-J., Timothy J. Key, Meredith Yeager, Robert A. Stephenson, Liesel M. FitzGerald, Robert A. Gardiner, Ali Amin Al Olama, Manuel R. Teixeira, Rudolph Kaaks, David P. Dearnaley, Hermann Brenner, Kathleen A. Cooney, Maren Weischer, Jan Lubinski, Angela Cox, Aritaya Lophatonanon, Ruth C. Travis, Jürgen Serth, Suzanne Kolb, David J. Hunter, Stig E. Bojesen, Felicity Lose, Jonathan J. Morrison, Dominika Wokołorczyk, W. Vogel, W. Isaacs, Freddie C. Hamdy, Siqun L. Zheng, N. van As, A. Thompson, N. Mahmud, Dallas R. English, S. N. Thibodeau, Roman Corral, Janet L. Stanford, Colin Cooper, Norihiko Tsuchiya, Gerald L. Andriole, T. Wahlfors, D Campa, Craig C. Teerlink, Kimmo Taari, Tomonori Habuchi, Esther M. John, Chris Parker, Richard B. Hayes, Dietrich Rothenbacher, João Vasco Santos, Børge G. Nordestgaard, Radka Kaneva, Peter Klarskov, Christopher A. Haiman, Loic Le Marchand, Graham G. Giles

Publikováno v: Amin Al Olama, A, Kote-Jarai, Z, Schumacher, F R, Wiklund, F, Berndt, S I, Benlloch, S, Giles, G G, Severi, G, Neal, D E, Hamdy, F C, Donovan, J L, Hunter, D J, Henderson, B E, Thun, M J, Gaziano, M, Giovannucci, E L, Siddiq, A, Travis, R C, Cox, D G, Canzian, F, Riboli, E, Key, T J, Andriole, G, Albanes, D, Hayes, R B, Schleutker, J, Auvinen, A, Tammela, T L J, Weischer, M, Stanford, J L, Ostrander, E A, Cybulski, C, Lubinski, J, Thibodeau, S N, Schaid, D J, Sorensen, K D, Batra, J, Clements, J A, Chambers, S, Aitken, J, Gardiner, R A, Maier, C, Vogel, W, Dörk, T, Brenner, H, Habuchi, T, Ingles, S, John, E M, Orntoft, T F, Borre, M & The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2013, ' A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease ', Human Molecular Genetics . https://doi.org/10.1093/hmg/dds425

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad9635bdca894a7ceabe93a36b9adbd
http://ora.ox.ac.uk/objects/uuid:893cadad-9be1-489c-98c8-8d1839820f96