Zobrazeno 1 - 7
of 7
pro vyhledávání: '"T. W. Vanderah"'
Autor:
A J, Sandweiss, M I, McIntosh, A, Moutal, R, Davidson-Knapp, J, Hu, A K, Giri, T, Yamamoto, V J, Hruby, R, Khanna, T M, Largent-Milnes, T W, Vanderah
Publikováno v:
Molecular psychiatry. 23(8)
Development of an efficacious, non-addicting analgesic has been challenging. Discovery of novel mechanisms underlying addiction may present a solution. Here we target the neurokinin system, which is involved in both pain and addiction. Morphine exert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79dcfd262079f5bd6abf503f4b1b6d03
https://pubmed.ncbi.nlm.nih.gov/28485408
https://pubmed.ncbi.nlm.nih.gov/28485408
Autor:
Mei-Chuan Ko, Stephen M. Husbands, Thomas M. Dodds, John W. Lewis, Mellar P. Davis, Shanthi Mogali, Sandra D. Comer, Andrew J. Saxon, Guy H. Hans, Nurulain T. Zaveri, Dennis Yasuda, Blair V. Journigan, Pankaj R. Daga, Faming Jiang, Cris Olsen, S. Stevens Negus, Ahmad A. Altarifi, Donald J. Kyle, Patrick J. Little, A. M. Symons-Liguori, T. W. Vanderah, Eduardo R. Butelman, Mary Jeanne Kreek, Jean M. Bidlack, Brian I. Knapp, Girolamo Calo’, Remo Guerrini, Garth T. Whiteside, Lawrence Toll, Taline V. Khroyan, Willma E. Polgar, Devki Sukhtankar
Autor:
T M, Largent-Milnes, T, Yamamoto, P, Nair, J W, Moulton, V J, Hruby, J, Lai, F, Porreca, T W, Vanderah
Publikováno v:
British journal of pharmacology. 161(5)
The use of opioids in treating pain is limited due to significant side effects including somnolence, constipation, analgesic tolerance, addiction and respiratory depression. Pre-clinical studies have shown that neurokinin 1 (NK(1) ) receptor antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e985cb32c9fbacf96f144ae2abed83a8
https://pubmed.ncbi.nlm.nih.gov/20977451
https://pubmed.ncbi.nlm.nih.gov/20977451
Publikováno v:
British journal of pharmacology. 161(1)
Long-term morphine treatment enhances pain neurotransmitter [such as calcitonin gene-related peptide (CGRP)] levels in the spinal cord. It has been suggested previously that increased spinal CGRP may contribute to sustained morphine-mediated paradoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c279b87d5b6d3a8fcc26c729f2ce7399
https://pubmed.ncbi.nlm.nih.gov/20718739
https://pubmed.ncbi.nlm.nih.gov/20718739
Publikováno v:
Molecular interventions. 1(3)
One of the curious but common consequences of opioid administration in the clinical setting is the induction, at sites uninvolved in the original presentation of discomfort, of pain itself. The induction of pain is also a reliable, measurable phenome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00fe000ab3dc6d129f90ea1731f181e2
https://pubmed.ncbi.nlm.nih.gov/14993349
https://pubmed.ncbi.nlm.nih.gov/14993349
Autor:
T W, Vanderah, K D, Wild, A E, Takemori, M, Sultana, P S, Portoghese, W D, Bowen, V J, Hruby, H I, Mosberg, F, Porreca
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(1)
The present study evaluated the effect of a brief exposure of mice to cold-water swim-stress (CWSS) on the antinociceptive potency of i.c.v. given morphine. No significant antinociceptive response could be demonstrated in the warm-water tail-flick te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d708e0ef31b57b24f142089be79dec7e
https://pubmed.ncbi.nlm.nih.gov/8229774
https://pubmed.ncbi.nlm.nih.gov/8229774
Autor:
T W, Vanderah, K D, Wild, A E, Takemori, M, Sultana, P S, Portoghese, W D, Bowen, H I, Mosberg, F, Porreca
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(1)
The present study has characterized the antinociceptive response to cold water swim-stress (CWSS) in mice using opioid-selective antagonists as well as tolerance and cross-tolerance approaches. Mice subjected to CWSS using water at 5 degrees C for 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d65a8c4e4e2d8503c3984b368749cf7
https://pubmed.ncbi.nlm.nih.gov/1320682
https://pubmed.ncbi.nlm.nih.gov/1320682