Výsledky vyhledávání - "T. W. Spithill"

Vaccination of sheep against Fasciola hepatica with glutathione S-transferase. Identification and mapping of antibody epitopes on a three-dimensional model of the antigen

Autor: J L Sexton, M C Wilce, T Colin, G L Wijffels, L Salvatore, S Feil, M W Parker, T W Spithill, C A Morrison

Publikováno v: The Journal of Immunology. 152:1861-1872

The glutathione S-transferases (FhGST) of the liver fluke Fasciola hepatica have been identified as novel vaccine candidates that protect sheep against a fluke infection. With the use of overlapping peptides covering the predicted amino acid sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77f7b2291033b98510b15237795a28b9
https://doi.org/10.4049/jimmunol.152.4.1861

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Host responses during experimental infection with Fasciola gigantica and Fasciola hepatica in Merino sheep II. Development of a predictive index for Fasciola gigantica worm burden

Autor: H W, Raadsma, N M, Kingsford, Suharyanta, T W, Spithill, D, Piedrafita

Publikováno v: Veterinary parasitology. 154(3-4)

This study reports on the predictive relationship between serological, immunological and pathological responses following experimental inoculation with incremental doses of Fasciola gigantica in sheep. Fifty, 6-month-old, naive Merino wethers were al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8aa8a8b1dfa958701871b244109e76da
https://pubmed.ncbi.nlm.nih.gov/18468797

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Host responses during experimental infection with Fasciola gigantica or Fasciola hepatica in Merino sheep I. Comparative immunological and plasma biochemical changes during early infection

Autor: H W, Raadsma, N M, Kingsford, Suharyanta, T W, Spithill, D, Piedrafita

Publikováno v: Veterinary parasitology. 143(3-4)

This study reports the early biochemical changes in plasma, comparative host-immune responses and parasite recovery data in Merino sheep during the first 10 weeks of infection with Fasciola gigantica and Fasciola hepatica. One group of sheep were uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfa0ed8d86e9255ff753f59536ca0a9e
https://pubmed.ncbi.nlm.nih.gov/17069976

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Akademický článek

Flavonoid-Quinoxaline Hybrid Compounds as Cathepsin Inhibitors Against Fascioliasis.

Autor: Ferraro F; Laboratorio de I+D de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Ruta 3 km 363, Paysandú, 60000, Uruguay., Merlino A; Laboratorio de Química Teórica y Computacional, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo, 11400, Uruguay., Gil J; Laboratorio de Reproducción Animal, Producción y Reproducción de Rumiantes, Departamento de Ciencias Biológicas, CENUR Litoral Norte-Facultad de Veterinaria, Universidad de la República, Ruta 3 km 363, Paysandú, 60000, Uruguay., Pérez-Silanes S; ISTUN Institute of Tropical Health, Department of Pharmaceutical Sciences, Universidad de Navarra, IdiSNA (Navarra Institute for Health Research), Campus Universitario, 31009, Pamplona, Spain., Corvo I; Laboratorio de I+D de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Ruta 3 km 363, Paysandú, 60000, Uruguay., Cabrera M; Laboratorio de I+D de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Ruta 3 km 363, Paysandú, 60000, Uruguay.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Sep 16; Vol. 19 (18), pp. e202400305. Date of Electronic Publication: 2024 Aug 09.

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Antibody-dependent cell-mediated cytotoxicity to newly excysted juvenile Fasciola hepatica in vitro is mediated by reactive nitrogen intermediates

Autor: D, Piedrafita, J C, Parsons, R M, Sandeman, P R, Wood, S E, Estuningsih, S, Partoutomo, T W, Spithill

Publikováno v: Parasite immunology. 23(9)

Passive intraperitoneal transfer of sera from Fasciola hepatica-infected sheep, cattle or rats can protect naive rats from F. hepatica infection, suggesting a parasite killing mechanism within the peritoneal cavity that is dependent on the presence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1dc6ed6503f942063fa6c5b8f529df5
https://pubmed.ncbi.nlm.nih.gov/11589776

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Developmental expression of a Fasciola hepatica sequence homologous to ABC transporters

Autor: M B, Reed, M, Panaccio, R A, Strugnell, T W, Spithill

Publikováno v: International journal for parasitology. 28(9)

Polymerase chain reaction and cDNA library screening approaches were employed to identify a putative member of the highly conserved family of ATP-binding cassette transport proteins from Fasciola hepatica. At the predicted protein level, the F. hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17fd6a8e33839641ecb46a1e0921a634
https://pubmed.ncbi.nlm.nih.gov/9770623

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Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase

Autor: J, Rossjohn, S C, Feil, M C, Wilce, J L, Sexton, T W, Spithill, M W, Parker

Publikováno v: Journal of molecular biology. 273(4)

Glutathione S-transferases (GSTs) represent the major class of detoxifying enzymes from parasitic helminths. As a result, they are candidates for chemotherapeutic and vaccine design. Indeed, GSTs from Fasciola hepatica have been found to be effective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1d0edadb22b51bb3eb9a8c44f3c5b10
https://pubmed.ncbi.nlm.nih.gov/9367777

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Variants of a Leishmania surface antigen derived from a multigenic family

Autor: P J, Murray, T W, Spithill

Publikováno v: The Journal of biological chemistry. 266(36)

The promastigote surface antigen-2 (PSA-2) complex comprises a group of immunogenic surface antigens linked to the surface of the Leishmania major promastigote with glycosylphosphatidylinositol anchors. The L. major genome contains at least 14 PSA-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5611956e34d3f6b5cbbff552decb44e6
https://pubmed.ncbi.nlm.nih.gov/1761547

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