Zobrazeno 1 - 6
of 6
pro vyhledávání: '"T. W. Schulte"'
Autor:
Mikhail V. Blagosklonny, Leonard M. Neckers, J F Johnston, J F Mushinski, B P Monia, Phuongmai Nguyen, Jane B. Trepel, L Romanova, T W Schulte
Publikováno v:
Molecular and Cellular Biology. 16:5839-5845
The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus. Raf-1 integrates signals coming from extracellular factors and, in turn, activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbc71d637aea21af62ae7b6a214024e
https://doi.org/10.1128/mcb.16.10.5839
https://doi.org/10.1128/mcb.16.10.5839
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 11(7)
Several important signaling proteins including transcription factors and protein kinases depend on heat shock protein (Hsp)-90 for stability. p210bcr-abl, a protein expressed in chronic myelogenous leukemia, is functionally inhibited by the benzoquin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::871d150c0e7f49e9299076aef7c59797
https://pubmed.ncbi.nlm.nih.gov/10939589
https://pubmed.ncbi.nlm.nih.gov/10939589
Autor:
S, Soga, L M, Neckers, T W, Schulte, Y, Shiotsu, K, Akasaka, H, Narumi, T, Agatsuma, Y, Ikuina, C, Murakata, T, Tamaoki, S, Akinaga
Publikováno v:
Cancer research. 59(12)
Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone, interfering with its function. Hsp90 family chaperones have been shown to associate with several signaling molecules and play an es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cce2aad037bfbbe406b0bfa7df4eac5f
https://pubmed.ncbi.nlm.nih.gov/10383157
https://pubmed.ncbi.nlm.nih.gov/10383157
Publikováno v:
Stress Proteins ISBN: 9783642635199
Heat shock protein 90 (Hsp90) is one of the most abundant proteins in eukaryotic cells, comprising 1-2% of total cellular protein even under non-stress conditions. Hsp90 is highly evolutionarily conserved, with homologs in such divergent species as b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5868fe13781201905c924968a0951ae2
https://doi.org/10.1007/978-3-642-58259-2_2
https://doi.org/10.1007/978-3-642-58259-2_2
Publikováno v:
Cell stresschaperones. 3(2)
The molecular chaperone Hsp90 plays an essential role in the folding and function of important cellular proteins including steroid hormone receptors, protein kinases and proteins controlling the cell cycle and apoptosis. A 15 Å deep pocket region i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9fa2e8eb81de8804889f88c0b1b3294
https://pubmed.ncbi.nlm.nih.gov/9672245
https://pubmed.ncbi.nlm.nih.gov/9672245
Publikováno v:
Cancer research. 55(20)
Taxol stabilizes microtubules, prevents tubulin depolymerization, and promotes tubulin bundling and is one of the most effective drugs for the treatment of metastatic breast and ovarian cancer. Although its interaction with tubulin has been well char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83ad5d0b1d88541957fbb00ba2d62d94
https://pubmed.ncbi.nlm.nih.gov/7553639
https://pubmed.ncbi.nlm.nih.gov/7553639