Zobrazeno 1 - 10
of 375
pro vyhledávání: '"T. W. Sadler"'
Autor:
Ruth Bevis
Publikováno v:
Paediatric Nursing. 4:14-14
Publikováno v:
Teratology. 64:114-122
Background Choline is an essential nutrient in methylation, acetylcholine and phospholipid biosynthesis, and in cell signaling. The demand by an embryo or fetus for choline may place a pregnant woman and, subsequently, the developing conceptus at ris
Autor:
T W Sadler
Publikováno v:
Environmental Health Perspectives
One of the original principles of teratology states that, "Susceptibility to teratogenesis varies with the developmental stage at the time of exposure to an adverse influence" [Wilson JG. Environment and Birth Defects. New York:Academic Press, 1973].
Autor:
T. W. Sadler
Publikováno v:
Mental Retardation and Developmental Disabilities Research Reviews. 4:247-253
Neural tube closure (neurulation) is a complex process involving many cell phenomena. Both extrinsic and intrinsic forces are essential to elevate the neural plate into the neural folds and to bring the folds into apposition for closure. Extrinsic fo
Autor:
Patricia F. Maness, T. W. Sadler, Jean M. Lauder, Harold C. Slavkin, Phil Mirkes, Kathy Sulik, Elwood Linney, Melissa B. Rogers
Publikováno v:
Reproductive Toxicology. 11:331-337
The work group identified a number of research areas where they felt there were significant data gaps where additional research was critical to better understanding of the origins of birth defects and to developing ways for their prevention. These in
Autor:
T. W. Sadler, Jennifer H. Peet
Publikováno v:
Teratology. 54:20-26
Children of mothers with insulin-dependent diabetic mothers (IDDM) have a 2–4 times higher incidence of congenital birth defects as compared to the general population, including cardiac abnormalities, of unknown etiology. Using rodent embryos to ex
Publikováno v:
Teratology. 51:300-310
The roles ofengrailed-1 (En-1) andengrailed-2 (En-2) have been investigated during gastrulation and neurulation in mouse embryos. Using antisense oligonucleotides and murine whole embryo culture, early somite embryos were injected with antisense phos
Publikováno v:
Toxicology in Vitro. 8:413-421
The adverse developmental effects of ethanol consumption have been documented in humans and in animal models. In animal models, the organ system affected by ethanol administration is dependent on the point in gestation at which the xenobiotic is admi
Publikováno v:
Diabetes. 43:656-660