Zobrazeno 1 - 10
of 19
pro vyhledávání: '"T. W. Kay"'
Autor:
M. Waibel, H. E. Thomas, J. M. Wentworth, J. J. Couper, R. J. MacIsaac, F. J. Cameron, M. So, B. Krishnamurthy, M. C. Doyle, T. W. Kay
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Type 1 diabetes (T1D) places an extraordinary burden on individuals and their families, as well as on the healthcare system. Despite recent advances in glucose sensors and insulin pump technology, only a minority of patients meet
Externí odkaz:
https://doaj.org/article/933b5182f2e541f6a5ee8c89d3303a19
Publikováno v:
The Journal of Immunology. 157:3688-3693
Beta2m-deficient nonobese diabetic (NODbeta2mnull) do not develop insulitis or diabetes. Expression of a beta2m transgene controlled by the rat insulin promoter (RIP-beta2m) in NODbeta2mnull mice resulted in reconstitution of IFN-gamma-inducible cell
Publikováno v:
Diabetes. 50(11)
Several self-antigens have been reported as targets of the autoimmune response in nonobese diabetic (NOD) mice. The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in this animal model for ty
Autor:
J L, McQualter, R, Darwiche, C, Ewing, M, Onuki, T W, Kay, J A, Hamilton, H H, Reid, C C, Bernard
Publikováno v:
The Journal of Experimental Medicine
Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, can be induced by immunization with a number of myelin antigens. In particular, myelin oligodendrocyte glycoprotein, a central nervous system (CNS)-specific antigen expr
Autor:
H E, Thomas, T W, Kay
Publikováno v:
Current directions in autoimmunity. 4
Autor:
H E, Thomas, T W, Kay
Publikováno v:
Diabetes/metabolism research and reviews. 16(4)
In the non-obese diabetic (NOD) mouse model of Type 1 (insulin-dependent) diabetes, evidence suggests that pancreatic beta cells are destroyed in part by apoptotic mechanisms. The precise mechanisms of beta cell destruction leading to diabetes remain
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(3)
Recent studies suggest that Fas expression on pancreatic beta cells may be important in the development of autoimmune diabetes in the nonobese diabetic (NOD) mouse. To address this, pancreatic islets from NOD mice were analyzed by flow cytometry to d
Publikováno v:
The Journal of rheumatology. 26(3)
To ascertain the clinical and serological associations of anti-Ku antibody.Twenty-seven patients over a 7 year period (1987-1996) had anti-Ku antibody detected by counterimmunoelectrophoresis (CIEP). Nineteen patients were available for clinical revi
Publikováno v:
Transplantation. 67(3)
In this study, the role of cell-mediated cytotoxicity by human leukocytes against pig endothelial cells was examined in vitro. The aim was to determine which cell subsets were responsible for this phenomenon and which pathways were involved in cell l
Publikováno v:
Molecular medicine (Cambridge, Mass.). 4(8)
BACKGROUND: The non-obese diabetic (NOD) mouse is a model of human type 1 diabetes in which autoreactive T cells mediate destruction of pancreatic islet beta cells. Although known to be triggered by cytotoxic T cells, apoptosis has not been unequivoc