Výsledky vyhledávání

Screening of potential non-azole inhibitors of lanosterol14-alpha demethylase (CYP51) of Candida fungi

Autor: A S Ivanov, T. V. Shkel, Sergei A. Usanov, Oksana Gnedenko, L. A. Kaluzhskiy, Andrey Gilep, E O Yablokov, Yuri Mezentsev, P V Ershov

Publikováno v: Biomeditsinskaya Khimiya. 67:42-50

Currently, opportunistic fungi of the genus Candida are the main causative agents of mycoses, which are especially severe upon condition of acquired immunodeficiency. The main target for the development of new antimycotics is the cytochrome P450 51 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c0a0380bed756057a01badbc2e4231
https://doi.org/10.18097/pbmc20216701042

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SPR Analysis of Protein-Protein Interactions Involving Cytochromes P450 and Cytochrome b5 Integrated into Lipid Membrane

Autor: A S Ivanov, T. V. Shkel, E O Yablokov, G. V. Sergeev, K. S. Kurpedinov, P V Ershov, L. A. Kaluzhskiy, I. V. Haidukevich, Sergei A. Usanov, D. S. Sonina

Publikováno v: Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 14:168-173

Identification of new protein-protein interactions (PPI) and characterization of quantitative parameters of complex formation represent one of central tasks of modern protein interactomics. This study is a logical continuation of the cycle of our pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10174d0fdbee09db6c3481700ac2e8f7
https://doi.org/10.1134/s1990750820020067

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In vitro interactions of abiraterone, erythromycin, and CYP3A4: implications for drug–drug interactions

Autor: Andrei A. Gilep, Alexander V. Dmitriev, Natallia Strushkevich, Yaraslau I. Haurychenka, Victoria V. Shumyantseva, Rami A. Masamrekh, T. V. Shkel, Alexander V. Veselovsky, Maria G. Zavialova, Alexey V. Kuzikov, Dmitrii Filimonov, Kirill Shcherbakov, Sergey A. Usanov, Alexander I. Archakov

Publikováno v: Fundamental & Clinical Pharmacology. 34:120-130

Potential drug-drug interactions of the antitumor drug abiraterone and the macrolide antibiotic erythromycin were studied at the stage of cytochrome P450 3A4 (CYP3A4) biotransformation. Using differential spectroscopy, we have shown that abiraterone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71615d211a32cc1986582c0717ca35be
https://doi.org/10.1111/fcp.12497

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Protein-ligand interactions of CYP51 Candida glabrata and human CYP11В1 with 7-substituted 19-nortestosterones

Autor: Andrey Gilep, Irina Grabovec, Vladimir I. Dolgopalets, Tatsiana Varaksa, T. V. Shkel, Yu. G. Charnou, Natalya V. Strushkevich

Publikováno v: Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 54:450-454

The interaction of human monooxygenases and pathogenic fungi with previously obtained esters of isomeric 7-methyl-19-nor-testosterones and a number of heteroaromatic acids – derivatives of pyridine and pyrazine, was studied. Interaction with the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4afd9f98e7c1f550e266a0b204d6d45
https://doi.org/10.29235/1561-8331-2018-54-4-450-454

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Interaction of prostacyclin synthase with cytochromes P450

Autor: A S Ivanov, T. V. Shkel, S A Usanov, A. A. Gilep, P V Ershov, Natallia Strushkevich, Oksana Gnedenko, E O Yablokov, A V Svirid, I. V. Haidukevich

Publikováno v: Biomeditsinskaya Khimiya. 65:63-66

Biosensor experiments on investigation of interaction between prostacyclin synthase (PGIS) and different proteins of the cytochrome P450 monooxygenase systems were perfomed. Interaction of PGIS with microsomal (CYP21A2, CYP2E1) and mitochondrial (CYP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92c16602fda5159ddc7d918abacc260
https://doi.org/10.18097/pbmc20196501063

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Transformations, NMR studies and biological testing of some 17β-isoxazolyl steroids and their heterocyclic ring cleavage derivatives

Autor: Natallia Strushkevich, T. V. Shkel, Alexander V. Baranovsky, Andrey Gilep, Alesya Ladyko, Sergey Sokolov

Publikováno v: Steroids. 166

The synthesis and NMR structure analysis of a group of oxygenated steroids containing isoxazole, dihydrofuran, tetrahydrofuran rings or enamino carbonyl fragment in the side chain have been fulfilled. The prepared compounds were tested toward several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5397afba1013c0c1da57cce04c976eb1
https://pubmed.ncbi.nlm.nih.gov/33232722

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Interaction of 17α-hydroxylase, 17(20)-lyase (CYP17A1) inhibitors – abiraterone and galeterone – with human sterol 14α-demethylase (CYP51A1)

Autor: Alexander V. Veselovsky, Sergey A. Usanov, T. V. Shkel, Rami A. Masamrekh, Alexey V. Kuzikov, Natalia Strushkevich, Victoria V. Shumyantseva, Andrei A. Gilep, Alexander I. Archakov, Iliya Toropygin

Publikováno v: Journal of Inorganic Biochemistry. 186:24-33

Abiraterone and galeterone induce type I differential spectral changes in human sterol 14α-demethylase (cytochrome P450 51A1, CYP51A1) with the sigmoidal shape of the binding curve. After approximation of the data by Hill model, the half-saturation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e2858cc7f3515fe5c8fcfeff125a6d
https://doi.org/10.1016/j.jinorgbio.2018.05.010

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Thermodynamics of interactions between mammalian cytochromes P450 and b5

Autor: A. A. Gilep, T. V. Shkel, I. V. Haidukevich, Natallia Strushkevich, E O Yablokov, Andrew Ivanov, Alexei Medvedev, Alexander Luschik, A. V. Florinskaya, Sergey A. Usanov, G. V. Sergeev

Publikováno v: Archives of Biochemistry and Biophysics. 619:10-15

Cytochromes P450 (CYPs) play an important role in the metabolism of xenobiotics and various endogenous substrates. Being a crucial component of the microsomal monooxygenase system, CYPs are involved in numerous protein-protein interactions. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2adc560ea1e089f93adecd778986635
https://doi.org/10.1016/j.abb.2017.02.006

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