Zobrazeno 1 - 10
of 34
pro vyhledávání: '"T. Timothy Chen"'
Autor:
Claudia R. Baquet, Sandra E. Brooks, James F. Gardner, Chuanfa Guo, C. Daniel Mullins, T. Timothy Chen
Publikováno v:
Gynecologic Oncology. 85:242-249
Objective. The objective was to study the association of age, comorbid illness, race, and type of hospital with resource use in patients undergoing hysterectomy and lymph node dissection for endometrial cancer. Methods. The study was a population-bas
Publikováno v:
Journal of Lower Genital Tract Disease. 6:17-22
Objectives. To evaluate the association of pre-visit anxiety with pre- and post-visit knowledge, satisfaction, and adherence to colposcopy follow-up visits. Methods. A group of 122 women presenting for colposcopy between July 1999 and May 2000 were s
Autor:
Sandra E. Brooks, T. Timothy Chen, Claudia R. Baquet, James F. Gardner, C. Daniel Mullins, Abhijit Ghosh
Publikováno v:
Gynecologic Oncology. 79:107-115
Objective. The aim of this study was to evaluate the association of age, race, and comorbid illness with procedures and complications in hospitalized patients with invasive carcinoma of the cervix in a statewide population-based database over a 3-yea
Autor:
T. Timothy Chen, Shang P. Lin
Publikováno v:
Communications in Statistics - Theory and Methods. 29:923-940
In the usual design and analysis of a phase II trial, there is no differentiation between complete response and partial response. Since complete response is considered more desirable this paper proposes a weighted score method which extends Simon's (
Publikováno v:
Communications in Statistics - Theory and Methods. 29:975-987
For phase I cancer clinical trials, toxicity is a major concern. Commonly, toxicity is categorized to five levels of severity. In addition to the traditional standard dose-escaiation design, the Continual Reassessment Method (CRM) provides a promisin
Autor:
T. Timothy Chen, Tie-Hua Ng
Publikováno v:
Statistics in Medicine. 17:2301-2312
In the conduct of a phase II cancer clinical trial, patients usually enter in two stages. If the response rate from the first stage is low, then the study terminates. Within various two-stage designs, Simon proposed the optimal and minimax criteria.
Autor:
Edward L. Kom, Richard M. Simon, Harry S. Wieand, T. Timothy Chen, Michael A. Friedman M D, Anne S. Lindblad, Bernard Fisher M.D, J. Michael Hamilton, M D Harold O. Douglass Jr, Stewart J. Anderson
Publikováno v:
Communications in Statistics - Theory and Methods. 27:1363-1378
A stochastic model wiuh exponential components is used to describe our data collected from a phase III cancer clinical trial. Criteria which guarantee that disease-free survival (DFS) can be used as a surrogate for overall survival are explored under
Autor:
T. Timothy Chen
Publikováno v:
Statistics in Medicine. 16:2701-2711
The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ine
Autor:
Richard Simon, T. Timothy Chen
Publikováno v:
Communications in Statistics - Theory and Methods. 25:947-965
In a two-treatment trial, a two-sided test is often used to reach a conclusion, Usually we are interested in doing a two-sided test because of no prior preference between the two treatments and we want a three-decision framework. When a standard cont
Autor:
T. Timothy Chen, Richard Simon
Publikováno v:
Communications in Statistics - Theory and Methods. 23:781-801
Dunnett's many-one test to compare several experimental treatment means with a control was extended in our previous paper to a decision procedure for selecting a desirable treatment when there is a strictly monotonic prior preference among the multip