Výsledky vyhledávání - "T. Tennenbaum"

Glucose effects on skin keratinocytes: implications for diabetes skin complications

Autor: N, Spravchikov, G, Sizyakov, M, Gartsbein, D, Accili, T, Tennenbaum, E, Wertheimer

Publikováno v: Diabetes. 50(7)

Altered skin wound healing is a common cause of morbidity and mortality among diabetic patients. However, the molecular mechanisms whereby diabetes alters skin physiology have not been elucidated. In this study, we investigated the relative roles of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0db258fe98f4fb6a16fd8e445c9e1ad9
https://pubmed.ncbi.nlm.nih.gov/11423485

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PKCdelta activation: a divergence point in the signaling of insulin and IGF-1-induced proliferation of skin keratinocytes

Autor: S, Shen, A, Alt, E, Wertheimer, M, Gartsbein, T, Kuroki, M, Ohba, L, Braiman, S R, Sampson, T, Tennenbaum

Publikováno v: Diabetes. 50(2)

Insulin and insulin-like growth factor-1 (IGF-1) are members of the family of the insulin family of growth factors, which activate similar cellular downstream pathways. In this study, we analyzed the effects of insulin and IGF-1 on the proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72149f305c574b4c9a2bbbeda7a2c284
https://pubmed.ncbi.nlm.nih.gov/11272134

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Differential localization of conventional protein kinase C isoforms during mouse oocyte development

Autor: A, Luria, T, Tennenbaum, Q Y, Sun, S, Rubinstein, H, Breitbart

Publikováno v: Biology of reproduction. 62(6)

Protein kinase C (PKC), the major cell target for tumor-promoting phorbol esters, plays a central role in signal transduction pathways. In many biological systems where Ca(2+) serves as a second messenger, regulatory control is mediated by PKC. The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ed33750bca8dea308796c5b899ff486
https://pubmed.ncbi.nlm.nih.gov/10819756

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Cell cycle-dependent nuclear accumulation of the p94fer tyrosine kinase is regulated by its NH2 terminus and is affected by kinase domain integrity and ATP binding

Autor: I, Ben-Dor, O, Bern, T, Tennenbaum, U, Nir

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(2)

p94fer and p51ferT are two tyrosine kinases that are encoded by differentially spliced transcripts of the FER locus in the mouse. The two tyrosine kinases share identical SH2 and kinase domains but differ in their NH2-terminal amino acid sequence. Un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c62e1d187416fb9198826268aabda9e
https://pubmed.ncbi.nlm.nih.gov/10074905

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Insulin receptor regulation of cell surface integrins: a possible mechanism contributing to the development of diabetic complications

Autor: E, Wertheimer, S I, Taylor, T, Tennenbaum

Publikováno v: Proceedings of the Association of American Physicians. 110(4)

Insulin plays a central role in regulating cellular growth in addition to its classic effects to regulate fuel metabolism. In a previous study, we have identified a patient who was homozygous for a deletion of the insulin receptor gene. In our curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07fbf66074f912b220aa510325b83c47
https://pubmed.ncbi.nlm.nih.gov/9686681

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Selective changes in laminin adhesion and alpha 6 beta 4 integrin regulation are associated with the initial steps in keratinocyte maturation

Autor: T, Tennenbaum, L, Li, A J, Belanger, L M, De Luca, S H, Yuspa

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(5)

In skin, the distribution of integrins is compartmentalized. Whereas the alpha 6 beta 4 integrin complex is polarized to the basal portion of proliferating cells in the basal layer juxtaposed to the basement membrane, alpha 3 beta 1 integrin receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd2a058edbbcd6573dfbc7d1db929f10
https://pubmed.ncbi.nlm.nih.gov/8732671

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Differential regulation of integrins and extracellular matrix binding in epidermal differentiation and squamous tumor progression

Autor: T, Tennenbaum, A J, Belanger, V, Quaranta, S H, Yuspa

Publikováno v: The journal of investigative dermatology. Symposium proceedings. 1(2)

Cell surface receptors of the integrin family regulate physiological and pathological processes in skin, including proliferation, differentiation, and malignant transformation. In skin, integrins are compartmentalized. While alpha 6 beta 4 is restric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddd91cda0858d8a024bb795e553d0c75
https://pubmed.ncbi.nlm.nih.gov/9627711

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