Zobrazeno 1 - 10
of 770
pro vyhledávání: '"T. Seppälä"'
Publikováno v:
JPRAS Open, Vol 32, Iss , Pp 79-87 (2022)
Summary: We analyzed treatment, outcome, and risk factors for skin necrosis of 60 patients aged ≥65 years treated for a pretibial hematoma in the province of Kymenlaakso, Finland, between 2015 and 2019. Reviewing patients’ medical records reveale
Externí odkaz:
https://doaj.org/article/ea028a9a20b94508867f474bc31d4579
Publikováno v:
BJS Open, Vol 4, Iss 4, Pp 685-692 (2020)
Background This population‐based study aimed to examine the incidence, patterns and results of multimodal management of metastatic colorectal cancer. Methods A retrospective population‐based study was conducted on patients with metastatic colorec
Externí odkaz:
https://doaj.org/article/bdb00a05298a4efebf90257beaf67506
Autor:
Casie S. Kubota, Stephanie L. Myers, Toni T. Seppälä, Richard A. Burkhart, Peter J. Espenshade
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101964- (2024)
Objective: Cancer cells must maintain lipid supplies for their proliferation and do so by upregulating lipogenic gene programs. The sterol regulatory element-binding proteins (SREBPs) act as modulators of lipid homeostasis by acting as transcriptiona
Externí odkaz:
https://doaj.org/article/d8ae974546924ca99dcf0bbe44ca3440
Autor:
Tiina A. Jokela, Jari E. Karppinen, Minta Kärkkäinen, Jukka-Pekka Mecklin, Simon Walker, Toni T. Seppälä, Eija K. Laakkonen
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases cancer risk in individuals with Lyn
Externí odkaz:
https://doaj.org/article/3f400ed7cf2b456d9343fa786c1eee1c
Autor:
Erkki-Ville Wirta, Säde Szeto, Hanna Koppatz, Arno Nordin, Heikki Mäkisalo, Johanna Arola, Jukka Sirén, Maarit Ahtiainen, Jan Böhm, Jukka-Pekka Mecklin, Ville Sallinen, Toni T. Seppälä
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAntitumoral immune response has a crucial role in constraining cancer. However, previous studies on cholangiocarcinoma (CCA), a rare and aggressive cancer, have reported contradictory findings on the prognostic impact of tumor-infiltrating
Externí odkaz:
https://doaj.org/article/6ba3ee274f80408593b61e0eb61c28df
Autor:
Mev Dominguez-Valentin, Toni T. Seppälä, Julian R. Sampson, Finlay Macrae, Ingrid Winship, D. Gareth Evans, Rodney J. Scott, John Burn, Gabriela Möslein, Inge Bernstein, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, Annika Lindblom, John-Paul Plazzer, Douglas Tjandra, Huw Thomas, Kate Green, Fiona Lalloo, Emma J. Crosbie, James Hill, Gabriel Capella, Marta Pineda, Matilde Navarro, Joan Brunet Vidal, Karina Rønlund, Randi Thyregaard Nielsen, Mette Yilmaz, Louise Laurberg Elvang, Lior Katz, Maartje Nielsen, Sanne W. ten Broeke, Sigve Nakken, Eivind Hovig, Lone Sunde, Matthias Kloor, Magnus v Knebel Doeberitz, Aysel Ahadova, Noralane Lindor, Verena Steinke-Lange, Elke Holinski-Feder, Jukka-Pekka Mecklin, Pål Møller
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 17, Iss 1, Pp 1-6 (2019)
Abstract Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC
Externí odkaz:
https://doaj.org/article/4ac58fe8db1a436aa483dbd310b61d26
Autor:
OC Astrup, O Aae, T Kuś, O Uyanik, B Biterling, T Bars, M Polini, Vijaya G, K Yu, T Seppälä, MJ Son
Publikováno v:
International Journal of Maritime Engineering. 164:91-112
Shipyards and classification societies must modify the traditional design documentation and review process and enable a direct 3D digital classification process to improve the exchange of information between the different stakeholders and ultimately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382554e3fc93488e97d2103471394c99
https://doi.org/10.5750/ijme.v164ia2.1231
https://doi.org/10.5750/ijme.v164ia2.1231
Publikováno v:
BJS Open. 7
Background Inheritance patterns show familial clustering of gastrointestinal cancers, and multiple germline conditions have now been identified that predispose to colorectal, gastric, and pancreatic cancers. Methods A narrative review based on recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd94080a525c77f3fedf13a163a795db
https://doi.org/10.1093/bjsopen/zrad023
https://doi.org/10.1093/bjsopen/zrad023
Autor:
Meeri Kastinen, Päivi Sirniö, Hanna Elomaa, Maarit Ahtiainen, Sara A. Väyrynen, Karl-Heinz Herzig, Sanna Meriläinen, Raila Aro, Reetta Häivälä, Tero Rautio, Juha Saarnio, Erkki-Ville Wirta, Olli Helminen, Toni T. Seppälä, Teijo Kuopio, Jan Böhm, Anne Tuomisto, Jukka-Pekka Mecklin, Markus J. Mäkinen, Juha P. Väyrynen
Publikováno v:
British Journal of Cancer.
Background Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2490fa35ee881199ef31b4d16ce96183
https://doi.org/10.1038/s41416-023-02258-2
https://doi.org/10.1038/s41416-023-02258-2
Autor:
John Burn, D. Timothy Bishop, Gillian M. Borthwick, Lynn Reed, Kirsi Pylvänäinen, Harsh J. Sheth, Huw J.W. Thomas, Toni T. Seppälä, Raj S. Ramesar, Jem Rashbass, Patrick J. Morrison, Annika Lindblom, Judy W.C. Ho, Anne-Marie Gerdes, D. Gareth Evans, Lucio Bertario, Fiona E. McRonald, Gabriela Möslein, Jukka-Pekka Mecklin, Finlay Macrae, Faye Elliott, John C. Mathers
The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with Lynch syndrome (LS). Participants with LS were randomized double-blind to 30 g resistant starch (RS) daily or placebo for up to 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2488bf5c460109c2d372cc21de7983
https://doi.org/10.1158/1940-6207.c.6547703.v1
https://doi.org/10.1158/1940-6207.c.6547703.v1
