Zobrazeno 1 - 10
of 287
pro vyhledávání: '"T. Saxena"'
Autor:
Kevin Emmerich, David T. White, Siva P. Kambhampati, Grace L. Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T. Saxena, Steven L. Walker, Eric Betzig, Rangaramanujam M. Kannan, Jeff S. Mumm
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been applied to stimulate nascent regenerative responses in the mammalian retina. For instance, micro
Externí odkaz:
https://doaj.org/article/0098c0b5f2dd4606b3cf44ca818c8a43
Autor:
Kevin Emmerich, Steven L Walker, Guohua Wang, David T White, Anneliese Ceisel, Fang Wang, Yong Teng, Zeeshaan Chunawala, Gianna Graziano, Saumya Nimmagadda, Meera T Saxena, Jiang Qian, Jeff S Mumm
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010905 (2023)
Retinal Müller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish and mice. In zebrafish, retinal regeneration is innate and robust, resulting in the replacement of lost neurons and restoration of visual function. In mice
Externí odkaz:
https://doaj.org/article/c62e0f14c7364e70aaca457b9089e57d
Autor:
Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects
Externí odkaz:
https://doaj.org/article/ae361e62a3fd4acc8161a7ed3eae9011
Akademický článek
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Akademický článek
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Autor:
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, Hannah R Lee-Harwood, Elsie M Williams, Janine N Copp, Rory F Little, Jenni JB Francis, Claire N Horvat, Luke J Stevenson, Jeremy G Owen, Meera T Saxena, Jeff S Mumm, David F Ackerley
Publikováno v:
bioRxiv
SummaryFunctional screening of environmental DNA (eDNA) libraries is a potentially powerful approach to discover enzymatic “unknown unknowns”, but is usually heavily biased toward the tiny subset of genes preferentially transcribed and translated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a912240b02a0284245439c0f64bc50dc
https://doi.org/10.1101/2023.03.24.534183
https://doi.org/10.1101/2023.03.24.534183
Autor:
Arife Unal Eroglu, Timothy S. Mulligan, Liyun Zhang, David T. White, Sumitra Sengupta, Cathy Nie, Noela Y. Lu, Jiang Qian, Lisha Xu, Wuhong Pei, Shawn M. Burgess, Meera T. Saxena, Jeff S. Mumm
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Thousands of genes have been implicated in retinal regeneration, but only a few have been shown to impact the regenerative capacity of Müller glia—an adult retinal stem cell with untapped therapeutic potential. Similarly, among nearly 300 genetic
Externí odkaz:
https://doaj.org/article/26f4e85cc8724161b9abfd475abe72c6
Autor:
Abigail V. Sharrock, Timothy S. Mulligan, Kelsi R. Hall, Elsie M. Williams, David T. White, Liyun Zhang, Kevin Emmerich, Frazer Matthews, Saumya Nimmagadda, Selena Washington, Katherine D. Le, Danielle Meir-Levi, Olivia L. Cox, Meera T. Saxena, Anne L. Calof, Martha E. Lopez-Burks, Arthur D. Lander, Ding Ding, Hongkai Ji, David F. Ackerley, Jeff S. Mumm
Publikováno v:
Nature methods, vol 19, iss 2
Transgenic expression of bacterial nitroreductase (NTR) enzymes sensitizes eukaryotic cells to prodrugs such as metronidazole (MTZ), enabling selective cell-ablation paradigms that have expanded studies of cell function and regeneration in vertebrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fc22cea9ed01529cf478d87a37f105
https://escholarship.org/uc/item/1fn995n4
https://escholarship.org/uc/item/1fn995n4
Background & Aims: Diagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously published criteria focused mainly on chronic AIH, in which inflammatory changes mainly occur in portal/periportal regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::e5ec28cfbca88c7b775beaf857b1f8eb
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3118676
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3118676
Publikováno v:
Adv Drug Deliv Rev
Several key attributes of zebrafish make them an ideal model system for the discovery and development of regeneration promoting therapeutics; most notably their robust capacity for self-repair which extends to the central nervous system. Further, by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d48ddc43d977f6dd75fb4f58c82b29
https://doi.org/10.1016/j.addr.2019.01.011
https://doi.org/10.1016/j.addr.2019.01.011