Zobrazeno 1 - 10
of 14
pro vyhledávání: '"T. S. Tracy"'
microRNA-34a is associated with expression of key hepatic transcription factors and cytochromes P450
Publikováno v:
Biochemical and Biophysical Research Communications. 445:404-411
microRNA (miRNA) mediated regulation of gene expression has emerged as a significant mechanism contributing to variation in gene expression. In this study, we evaluated the potential role of miRNAs in regulating expression of hepatic cytochrome P450s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802dfa0555ff6899bd7b4a20a51a0da3
https://doi.org/10.1016/j.bbrc.2014.02.024
https://doi.org/10.1016/j.bbrc.2014.02.024
Autor:
Charles W. Locuson, T S Tracy
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 37(2)
UDP-glucuronosyltranferases (UGTs) affect the disposition of drugs and other xenobiotics by catalysing the conjugation of glucuronic acid to available oxygen, nitrogen, and sulfur atoms. Several related mammalian isoforms of UGT are expressed that ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75881ef5ba407c31d51ba94e6869209c
https://pubmed.ncbi.nlm.nih.gov/17484518
https://pubmed.ncbi.nlm.nih.gov/17484518
Publikováno v:
Journal of endodontics. 26(12)
To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5206aa41b75c25fad3d9a17206ef3fb
https://pubmed.ncbi.nlm.nih.gov/11471639
https://pubmed.ncbi.nlm.nih.gov/11471639
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(7)
Dapsone activates CYP2C9-mediated metabolism in various expression systems and is itself metabolized by CYP2C9 to its hydroxylamine metabolite. Studies were conducted with expressed CYP2C9 to characterize the kinetic effects of dapsone (0-100 microM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b74fceae1b67b964b843561174acdfc
https://pubmed.ncbi.nlm.nih.gov/11408370
https://pubmed.ncbi.nlm.nih.gov/11408370
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 24(2)
Protein-calorie malnutrition (PCM) can develop both from inadequate food intake and as a consequence of diseases such as cancer and AIDS. Several studies have shown that PCM can alter drug clearance but little information is available on the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0995f9f9196d3166616b2912761757ca
https://pubmed.ncbi.nlm.nih.gov/10510741
https://pubmed.ncbi.nlm.nih.gov/10510741
Autor:
R J, Schmidt, J, Domico, L S, Samsell, S, Yokota, T S, Tracy, M I, Sorkin, K, Engels, C, Baylis
Publikováno v:
American journal of kidney diseases : the official journal of the National Kidney Foundation. 34(2)
Arginine deficiency and/or increased levels of circulating nitric oxide (NO) synthesis (NOS) inhibitors can cause reduced NOS, which may contribute to hypertension in patients with end-stage renal disease (ESRD). To test these hypotheses, NO oxidatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88df0ce8d49efca4cad0145356a1570a
https://pubmed.ncbi.nlm.nih.gov/10430967
https://pubmed.ncbi.nlm.nih.gov/10430967
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(4)
The placenta possesses the ability to metabolize a number of xenobiotics and endogenous compounds by processes similar to those seen in the liver. Animal and in vivo studies have observed that the presence of diabetes alters the expression of hepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffaf49781eb0fb2cef4d4a0260762263
https://pubmed.ncbi.nlm.nih.gov/9531526
https://pubmed.ncbi.nlm.nih.gov/9531526
Autor:
R A Parise, A Ogai, Allan E. Rettie, Kenneth R. Korzekwa, F J Gonzalez, T S Tracy, N Krishnamachary, Magang Shou
Publikováno v:
Biochemistry. 37(12)
Some cytochrome P450 catalyzed reactions show atypical kinetics, and these kinetic processes can be grouped into five categories: activation, autoactivation, partial inhibition, substrate inhibition, and biphasic saturation curves. A two-site model i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175a8d44cffcc93c7e55e94fc9035438
https://pubmed.ncbi.nlm.nih.gov/9521735
https://pubmed.ncbi.nlm.nih.gov/9521735
Publikováno v:
Biochemical pharmacology. 52(8)
Flurbiprofen, a non-steroidal anti-inflammatory drug (NSAID), is metabolized by both oxidation via the cytochrome P450 system and by glucuronidation. The major oxidative pathway in flurbiprofen metabolism is to a 4'-hydroxy metabolite, and recently w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::030c8cf42aa258bf6f5e334596ab75ed
https://pubmed.ncbi.nlm.nih.gov/8937439
https://pubmed.ncbi.nlm.nih.gov/8937439
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(1)
Ibuprofen [(racemic)2-(4-isobutylphenyl)propionic acid] undergoes metabolic inversion via formation, epimerization, and hydrolysis of the coenzyme A (CoA) thioester, ibuprofenyl-CoA. In this study, (R)-ibuprofen was incubated with either rat whole li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27ad2e790aa055a7f3b1c0fa8fa7e57b
https://pubmed.ncbi.nlm.nih.gov/8095203
https://pubmed.ncbi.nlm.nih.gov/8095203