Výsledky vyhledávání - "T. S. Kupper"

Autor: B. E. Rich, T. S. Kupper

Publikováno v: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5:243-250

IL-20 is a member of the IL-10 family of cytokines that also includes IL-10, IL-19, IL-22, IL-24, and IL-26 as well as a number of viral homologs. Keratinocytes and monocytes in states of activation can produce IL-20. It transmits signals via two dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9849fae4bb0eb715e18c0f91b8f5edd9
https://doi.org/10.2174/187152306778017683

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IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells

Autor: I R Williams, E A Rawson, L Manning, T Karaoli, B E Rich, T S Kupper

Publikováno v: The Journal of Immunology. 159:3044-3056

IL-7 is a keratinocyte-derived lymphocyte growth factor critical for the development of gammadelta T cells including murine dendritic epidermal T cells (DETC). We derived transgenic mice that overexpress IL-7 in basal keratinocytes under the control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3bc4e47c4d8444ee975538bfb382264
https://doi.org/10.4049/jimmunol.159.6.3044

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Constitutive expression of B7-1 (CD80) on mouse keratinocytes does not prevent development of chemically induced skin papillomas and carcinomas

Autor: I R Williams, R J Ort, D Daley, L Manning, T Karaoli, R L Barnhill, T S Kupper

Publikováno v: The Journal of Immunology. 156:3382-3388

Expression of the B7-1 (CD80) costimulatory molecule in a variety of tumor cell lines leads to an enhanced CD8+ T cell response to tumor Ags. We used transgenic mice constitutively expressing B7-1 on keratinocytes (K14/B7-1 line) to determine whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a01effc238ecf8e86fc2a36cee4a9e14
https://doi.org/10.4049/jimmunol.156.9.3382

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Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin

Autor: T A Ferguson, T S Kupper

Publikováno v: The Journal of Immunology. 150:1172-1182

It has been proposed that the migration of immune T cells out of blood vessels through connective tissue to the site of antigenic challenge is facilitated by the interaction of VLA integrins on lymphocytes with endothelial cell adhesion molecules and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::611057ba6115b84a0b3089b61a48dfce
https://doi.org/10.4049/jimmunol.150.4.1172

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1,24-Dihydroxyvitamin D₃ (tacalcitol) prevents skin T-cell infiltration

Autor: K-I, Yamanaka, M, Kakeda, H, Kitagawa, K, Tsuda, T, Akeda, I, Kurokawa, E C, Gabazza, T S, Kupper, H, Mizutani

Publikováno v: The British journal of dermatology. 162(6)

1,24-Dihydroxyvitamin D₃ (tacalcitol), a vitamin D(3) compound, has been used to treat T cell-mediated inflammatory skin diseases such as psoriasis, prurigo and vitiligo. The best-known mechanism of action of this compound is inhibition of the abno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ab4c26057e561539c27c75c88a7e1c3
https://pubmed.ncbi.nlm.nih.gov/20163421

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Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis

Autor: H, Rossiter, S, Beissert, C, Mayer, M P, Schön, B G, Wienrich, E, Tschachler, T S, Kupper

Publikováno v: Cancer research. 61(9)

The antiapoptotic protein bcl-2 is found up-regulated in a number of malignant and premalignant skin conditions of keratinocyte origin, but in normal skin, it is expressed at low levels only in interfollicular epidermis. To investigate whether unregu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9b0d71be3203127b94d889a0e3ae6d2
https://pubmed.ncbi.nlm.nih.gov/11325830

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Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen

Autor: T, Rauschmayr-Kopp, I R, Williams, F, Borriello, A H, Sharpe, T S, Kupper

Publikováno v: European journal of immunology. 28(12)

Productive interactions between B7-1 and B7-2 costimulatory molecules on dendritic cells (DC) and CD28 on T cells are thought to be critical for successful antigen presentation. Epicutaneous application of haptens induces both contact hypersensitivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::242d558dc64ab1f4809ee25d97db1c2e
https://pubmed.ncbi.nlm.nih.gov/9862359

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The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor

Autor: G J, Freeman, A A, Cardoso, V A, Boussiotis, A, Anumanthan, R W, Groves, T S, Kupper, E A, Clark, L M, Nadler

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(6)

The identification of all CD28/CTLA-4 counterreceptors is critical to our understanding of this pivotal pathway of T cell activation. Clouding our understanding has been the reported discrepancies in expression and function of the B7-1 (CD80) molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fca13464e8a2cc68a619facb03485b31
https://pubmed.ncbi.nlm.nih.gov/9743327

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Autor: I R, Williams, E A, Rawson, L, Manning, T, Karaoli, B E, Rich, T S, Kupper

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6b3449b27723c885ac70fb78924ecb3
https://pubmed.ncbi.nlm.nih.gov/9300730

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