Comparative oncology reveals DNMT3B as a molecular vulnerability in undifferentiated pleomorphic sarcoma

Autor: Ashley M. Fuller, Ann DeVine, Ileana Murazzi, Nicola J. Mason, Kristy Weber, T. S. Karin Eisinger-Mathason

Publikováno v: Cellular Oncology. 45:1277-1295

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e917853fc3508c58577a74c348eb2052
https://doi.org/10.1007/s13402-022-00717-1

Abstract PR001: Oncogene-induced matrix reorganization controls CD8+ T cell immunity in the UPS microenvironment

Autor: Ashley M. Fuller, Hawley C. Pruitt, Hoogeun Song, Ying Liu, Ann Devine, Rohan S. Katti, Samir Devalaraja, Gabrielle E. Ciotti, Michael Gonzalez, Erik F. Williams, Ileana Murazzi, Nicolas Skuli, Hakon Hakonarson, Kristy Weber, Malay Haldar, Joseph A. Fraietta, Sharon Gerecht, T. S. Karin Eisinger-Mathason

Publikováno v: Clinical Cancer Research. 28:PR001-PR001

CD8+ T cell dysfunction, characterized by reduced effector function, impaired proliferation, and inhibitory receptor upregulation, is a fundamental barrier to anti-tumor immunity. However, molecular mechanisms underlying the regulation of CD8+ T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7df6161bac8036aa0ae45d350c2b93b8
https://doi.org/10.1158/1557-3265.sarcomas22-pr001

Comparative oncology reveals DNMT3B as a molecular vulnerability in soft-tissue sarcoma

Autor: Ashley M. Fuller, Ann DeVine, Ileana Murazzi, Nicola J. Mason, Kristy Weber, T. S. Karin Eisinger-Mathason

Undifferentiated pleomorphic sarcoma (UPS), an aggressive subtype of soft-tissue sarcoma (STS), is exceedingly rare in humans and lacks effective, well-tolerated therapies. In contrast, STS are relatively common in canine companion animals; thus, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed4f6d3baec103d40c074f3482687bf3
https://doi.org/10.1101/2021.12.22.473852

Hypoxia and the Tumor Secretome

Autor: Ying, Liu, Gabrielle E, Ciotti, T S Karin, Eisinger-Mathason

Publikováno v: Advances in experimental medicine and biology. 1136

Metastasis remains the leading cause of cancer-related deaths. To date, there are no specific treatments targeting disseminated disease. New therapeutic options will become available only if we enhance our understanding of mechanisms underlying metas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e89f16d117883e4f545a881cc86560b8
https://pubmed.ncbi.nlm.nih.gov/31201716

Engineering Biomaterials to Model Immune-Tumor Interactions In Vitro.

Autor: Skirzynska A; Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, 160 College St, Toronto, ON, M5S 3E1, Canada., Xue C; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, 160 College St, Toronto, ON, M5S 3E1, Canada.; Institute for Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada., Shoichet MS; Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, 160 College St, Toronto, ON, M5S 3E1, Canada.; Institute for Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada.; Department of Chemistry, University of Toronto, 80 College Street, Toronto, ON, M5S 3H4, Canada.

Publikováno v: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 May; Vol. 36 (19), pp. e2310637. Date of Electronic Publication: 2024 Feb 23.