Zobrazeno 1 - 10
of 16
pro vyhledávání: '"T. S. Jokiranta"'
Autor:
T. Meri, H. Amdahl, M. J. Lehtinen, S. Hyvärinen, J. V. McDowell, A. Bhattacharjee, S. Meri, R. Marconi, A. Goldman, T. S. Jokiranta
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4 (2013)
Externí odkaz:
https://doaj.org/article/19813b158b314e6a8eb77451f029e798
Autor:
T Meri, H Amdahl, M J Lehtinen, S Hyvärinen, J V McDowell, A Bhattacharjee, S Meri, R Marconi, A Goldman, T S Jokiranta
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003308 (2013)
To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in pl
Externí odkaz:
https://doaj.org/article/65a8892b1c8446458d3e6542e5b059c7
Publikováno v:
FRIDAY, 15 JUNE 2018.
Background Infliximab (IFX) and adalimumab (ADL) are biological drugs used in the treatment of rheumatoid arthritis (RA), spondyloarthropathy (SpA), and juvenile idiopathic arthritis (JIA). Development of antidrug antibodies (ADAb) may lead to increa
Autor:
Matthew C. Pickering, A. R. Koskinen, T. S. Jokiranta, Zhu-Zhu Cheng, K. Kairemo, Seppo Meri, Taru Meri, H. T. Cook
Publikováno v:
Scandinavian Journal of Immunology. 88:e12671
Factor H is an important regulator of complement activation in plasma and on cell surfaces in both humans and mice. If FH function is compromised, inappropriate complement activation on self-surfaces can have disastrous effects as seen in the kidney
Autor:
E. Brandt, Seppo Meri, Peter F. Zipfel, Otto Götze, T. S. Jokiranta, Christine Skerka, Stefan Heinen, Martin Oppermann, T. Manuelian, Mihály Józsi
Publikováno v:
University of Helsinki
Summary The complement inhibitor Factor H has three distinct binding sites for C3b and for heparin, but in solution uses specifically the most C-terminal domain, i.e. short consensus repeats (SCR) 20 for ligand interaction. Two novel monoclonal antib
Autor:
Ken G. Dodds, R. J. McLaren, Kenneth P. McNatty, Mika Laitinen, Kaisu Luiro, Lisa Cambridge, Olli Ritvos, George H. Davis, A. E. Beattie, Jennifer L. Juengel, S. M. Galloway, T. S. Jokiranta, Grant W. Montgomery
Publikováno v:
Nature Genetics. 25:279-283
Multiple ovulations are uncommon in humans, cattle and many breeds of sheep. Pituitary gonadotrophins and as yet unidentified ovarian factors precisely regulate follicular development so that, normally, only one follicle is selected to ovulate. The I
Publikováno v:
The Journal of Immunology. 164:6075-6081
Of over 20 nucleated cell lines we have examined to date, human H2 glioblastoma cells have turned out to be the most resistant to complement-mediated cytolysis in vitro. H2 cells expressed strongly the membrane attack complex inhibitor protectin (CD5
Autor:
T. S. Jokiranta, H. K. Hockerstedt, Helena Isoniemi, Johanna Arola, Eija Tukiainen, Bo Nilsson, Arno Nordin, Aino Koskinen
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 11(9)
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy often caused by mutations in complement factor H (CFH), the main regulator of alternative complement pathway. Because CFH is produced mainly by the liver, combined liver-kidney
Autor:
T S Jokiranta, S Meri
Publikováno v:
The Journal of Immunology. 151:2124-2131
Biotinylation of mAb has become a standard procedure for a variety of applications that exploit the specific high affinity interaction between biotin and avidin. In the present study, we investigated how biotinylation of mAb affects their ability to
Autor:
Hannu Jalanko, Helena Isoniemi, Heikki Mäkisalo, Riitta Lassila, Eija Tukiainen, T. S. Jokiranta, G. Remuzzi, Seppo Meri, Christer Holmberg, J. Puntila, S. R. De Cordoba, A. Pinomäki, Aino Koskinen, Elina Armstrong, Jeffrey M. Saland, A. Koivusalo, S. Peltonen
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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A 12-month-old boy and his 16-year-old aunt became acutely ill 6 months apart and were diagnosed to have atypical hemolytic uremic syndrome (aHUS). Genetic analysis revealed heterozygous R1215Q mutation in complement factor H (CFH) in both patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f34a8c19ce3efa986c31e61185a16d
http://hdl.handle.net/10261/67345
http://hdl.handle.net/10261/67345