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Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.

Autor: Christina M Lill, Johannes T Roehr, Matthew B McQueen, Fotini K Kavvoura, Sachin Bagade, Brit-Maren M Schjeide, Leif M Schjeide, Esther Meissner, Ute Zauft, Nicole C Allen, Tian Liu, Marcel Schilling, Kari J Anderson, Gary Beecham, Daniela Berg, Joanna M Biernacka, Alexis Brice, Anita L DeStefano, Chuong B Do, Nicholas Eriksson, Stewart A Factor, Matthew J Farrer, Tatiana Foroud, Thomas Gasser, Taye Hamza, John A Hardy, Peter Heutink, Erin M Hill-Burns, Christine Klein, Jeanne C Latourelle, Demetrius M Maraganore, Eden R Martin, Maria Martinez, Richard H Myers, Michael A Nalls, Nathan Pankratz, Haydeh Payami, Wataru Satake, William K Scott, Manu Sharma, Andrew B Singleton, Kari Stefansson, Tatsushi Toda, Joyce Y Tung, Jeffery Vance, Nick W Wood, Cyrus P Zabetian, andMe Genetic Epidemiology of Parkinson's Disease Consortium, International Parkinson's Disease Genomics Consortium, Parkinson's Disease GWAS Consortium, Wellcome Trust Case Control Consortium 2), Peter Young, Rudolph E Tanzi, Muin J Khoury, Frauke Zipp, Hans Lehrach, John P A Ioannidis, Lars Bertram

Publikováno v: PLoS Genetics, Vol 8, Iss 3, p e1002548 (2012)

More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensive

Externí odkaz: https://doaj.org/article/cfc8c07e05884d89b6a183d737c73b81

A population genomic scan inChorthippusgrasshoppers unveils previously unknown phenotypic divergence

Autor: Isabelle Waurick, Emma L. Berdan, Camila J. Mazzoni, Johannes T. Roehr, Frieder Mayer

Publikováno v: Molecular Ecology. 24:3918-3930

Understanding the genetics of speciation and the processes that drive it is a central goal of evolutionary biology. Grasshoppers of the Chorthippus species group differ strongly in calling song (and corresponding female preferences) but are exceeding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc28706cdca1841b8b9049f37f35ad1d
https://doi.org/10.1111/mec.13276

Distinguishing true from false positives in genomic studies: p values

Autor: Johannes T. Roehr, Cornelia M. van Duijn, Najaf Amin, Maaike Schuur, Linda Broer, Christina M. Lill, John P. A. Ioannidis, Lars Bertram

Publikováno v: European Journal of Epidemiology, 28(2), 131-138. Springer Netherlands
European Journal of Epidemiology, 28(2), 131-8. Springer Netherlands
Broer, L, Lill, C M, Schuur, M, Amin, N, Roehr, J T, Bertram, L, Ioannidis, J P A & van Duijn, C M 2013, ' Distinguishing true from false positives in genomic studies : p values ', European Journal of Epidemiology, vol. 28, no. 2, pp. 131-8 . https://doi.org/10.1007/s10654-012-9755-x

Distinguishing true from false positive findings is a major challenge in human genetic epidemiology. Several strategies have been devised to facilitate this, including the positive predictive value (PPV) and a set of epidemiological criteria, known a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f411c2c4bd4b88bf52541cb24c7e9068
https://doi.org/10.1007/s10654-012-9755-x

Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3

Autor: Antonio R. Parrado, Johannes T. Roehr, Kristina Mullin, Christoph Lange, Tian Liu, Christine Herold, Lars Bertram, Rudolph E. Tanzi, Basavaraj Hooli, Manuel Mattheisen

Publikováno v: Molecular psychiatry 21(11), 1608-1612 (2016). doi:10.1038/mp.2015.218
Molecular psychiatry
Herold, C, Hooli, B V, Mullin, K, Liu, T, Roehr, J T, Mattheisen, M, Parrado, A R, Bertram, L, Lange, C & Tanzi, R E 2016, ' Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3 ', Molecular Psychiatry . https://doi.org/10.1038/mp.2015.218

The genetic basis of Alzheimer's disease (AD) is complex and heterogeneous. Over 200 highly penetrant pathogenic variants in the genes APP, PSEN1, and PSEN2 cause a subset of early-onset familial AD. On the other hand, susceptibility to late-onset fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc886fd065ebd8500cb0d13ba022f137
https://pub.dzne.de/record/141678