Zobrazeno 1 - 10
of 23
pro vyhledávání: '"T. Robert Wu"'
Publikováno v:
Molecules, Vol 15, Iss 9, Pp 5909-5927 (2010)
A modular strategy for the synthesis of hexacyclic dimeric resveratrol polyphenolic benzofurans is reported. The developed synthetic technology was applied to the total synthesis of malibatol A, shoreaphenol, and other biologically relevant poly-phen
Externí odkaz:
https://doaj.org/article/767bf89ec62c4d92a85b7405665fb5e5
Autor:
Ryan Kelly, Christine Allen, Jason Chio, Reina Bendayan, Nilasha Banerjee, John Forbes, Karin A. Stephenson, T. Robert Wu, John F. Valliant
Publikováno v:
Nuclear Medicine and Biology. 42:274-282
Introduction Organic Anion Transporting Polypeptides (OATP) are a family of membrane associated transporters that facilitate estrone-3-sulphate (E3S) uptake by hormone dependent, post-menopausal breast cancers. We have established E3S as a potential
Autor:
Ann J. Hessell, Dennis R. Burton, Benjamin F. Cravatt, Gang Lu, Juan Carlos de la Torre, Silvano Sanchini, David Sarlah, T. Robert Wu, Daniel K. Nomura, Beatrice Cubitt, Kyriacos C. Nicolaou
Publikováno v:
Proceedings of the National Academy of Sciences. 108:6715-6720
Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demon
Publikováno v:
Angewandte Chemie. 121:7002-7006
Publikováno v:
Angewandte Chemie International Edition. 48:6870-6874
Hirsutellones,[1] pyrrospirones,[2] and pyrrocidines[3] belong to a growing class of fungal secondary metabolites whose biological properties include antifungal and antibiotic activities. Particularly impressive are the activities of hirsutellones A
Publikováno v:
Angewandte Chemie. 121:3492-3495
Publikováno v:
Angewandte Chemie International Edition. 48:3440-3443
Similar, but different: Possessing almost the same but not identical structures, the recently discovered natural products hopeahainol A (1) and hopeanol (2) exhibit important but differing biological properties (see structures). Their first total syn
Autor:
Eric Rowcliffe, T. Robert Wu, Kyriacos C. Nicolaou, Dennis R. Burton, David M. Shaw, David Sarlah
Publikováno v:
Journal of the American Chemical Society. 130:11114-11121
Isolated from Hypericum species H. chinese L. var. salicifolium, biyouyanagin A was assigned structure 1a or 1b on the basis of NMR spectroscopic anaylsis. This novel natural product exhibited significant anti-HIV properties and inhibition of lipopol
Publikováno v:
Organic Letters. 13:5708-5710
The total synthesis of hirsutellones A (1), B (2), and C (3) has been achieved through a bioinspired late-stage sequence starting from advanced intermediate 6. The sequence proceeded via labile intermediate 17,1'-dehydrohirsutellone B (5) and deliver
Publikováno v:
ChemInform. 41
Plants of the Hypericum genus (Clusiaceae) have been known around the world for centuries for their medicinal properties. While H. perforatum (St. John’s wort), used to treat moderate depression,[1] is perhaps the most famous of these species, H. C