Zobrazeno 1 - 10
of 384
pro vyhledávání: '"T. Reinders"'
Autor:
F. A. Bogaards, T. Gehrmann, M. Beekman, N. Lakenberg, H. E. D. Suchiman, C. P. G. M. de Groot, M. J. T. Reinders, P. E. Slagboom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Molecular effects of lifestyle interventions are typically studied in a single tissue. Here, we perform a secondary analysis on the sex-specific effects of the Growing Old TOgether trial (GOTO, trial registration number GOT NL3301 ( https://
Externí odkaz:
https://doaj.org/article/3fe10dc5ea2c483585c22b8ce02587f2
Autor:
E. Onur Karakaslar, Jeppe F. Severens, Elena Sánchez-López, Peter A. van Veelen, Mihaela Zlei, Jacques J. M. van Dongen, Annemarie M. Otte, Constantijn J. M. Halkes, Peter van Balen, Hendrik Veelken, Marcel J. T. Reinders, Marieke Griffioen, Erik B. van den Akker
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract The diagnostic spectrum for AML patients is increasingly based on genetic abnormalities due to their prognostic and predictive value. However, information on the AML blast phenotype regarding their maturational arrest has started to regain i
Externí odkaz:
https://doaj.org/article/21d4317eb7704a259707b43c5a1bffc6
Autor:
J. M. Smit, J. H. Krijthe, W. M. R. Kant, J. A. Labrecque, M. Komorowski, D. A. M. P. J. Gommers, J. van Bommel, M. J. T. Reinders, M. E. van Genderen
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract This scoping review focuses on the essential role of models for causal inference in shaping actionable artificial intelligence (AI) designed to aid clinicians in decision-making. The objective was to identify and evaluate the reporting quali
Externí odkaz:
https://doaj.org/article/be441d244a7a4a9d8cfcfa801fb9c74f
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Most regulatory elements, especially enhancer sequences, are cell population-specific. One could even argue that a distinct set of regulatory elements is what defines a cell population. However, discovering which non-coding regions of the DNA are ess
Externí odkaz:
https://doaj.org/article/10f25c02cdec435488d23f8536c5a959
Autor:
Elisabeth M. Jongbloed, Maurice P. H. M. Jansen, Vanja de Weerd, Jean A. Helmijr, Corine M. Beaufort, Marcel J. T. Reinders, Ronald van Marion, Wilfred F. J. van IJcken, Gabe S. Sonke, Inge R. Konings, Agnes Jager, John W. M. Martens, Saskia M. Wilting, Stavros Makrodimitris
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Next generation sequencing of cell-free DNA (cfDNA) is a promising method for treatment monitoring and therapy selection in metastatic breast cancer (MBC). However, distinguishing tumor-specific variants from sequencing artefacts and germlin
Externí odkaz:
https://doaj.org/article/25950c21f0c9448e94b13a8b82eb4ebd
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract With the number of cells measured in single-cell RNA sequencing (scRNA-seq) datasets increasing exponentially and concurrent increased sparsity due to more zero counts being measured for many genes, we demonstrate here that downstream analys
Externí odkaz:
https://doaj.org/article/5a3f5316a3784966ba0e16d3ca4a8696
Autor:
Jim M. Smit, Jesse H. Krijthe, Andrei N. Tintu, Henrik Endeman, Jeroen Ludikhuize, Michel E. van Genderen, Shermarke Hassan, Rachida El Moussaoui, Peter E. Westerweel, Robbert J. Goekoop, Geeke Waverijn, Tim Verheijen, Jan G. den Hollander, Mark G. J. de Boer, Diederik A. M. P. J. Gommers, Robin van der Vlies, Mark Schellings, Regina A. Carels, Cees van Nieuwkoop, Sesmu M. Arbous, Jasper van Bommel, Rachel Knevel, Yolanda B. de Rijke, Marcel J. T. Reinders
Publikováno v:
Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Background Timely identification of deteriorating COVID-19 patients is needed to guide changes in clinical management and admission to intensive care units (ICUs). There is significant concern that widely used Early warning scores (EWSs) und
Externí odkaz:
https://doaj.org/article/adac0ffa1c414d52b8915466386d496a
Autor:
Daniele Bizzarri, Marcel J. T. Reinders, Marian Beekman, P. Eline Slagboom, Erik B. van den Akker, on behalf of the BbmriNl
Publikováno v:
Metabolites, Vol 13, Iss 12, p 1181 (2023)
1H-NMR metabolomics data is increasingly used to track health and disease. Nightingale Health, a major supplier of 1H-NMR metabolomics, has recently updated the quantification strategy to further align with clinical standards. Such updates, however,
Externí odkaz:
https://doaj.org/article/5341925a71934c5f8782ebdef6f923c8
Autor:
Mostafa Eltager, Tamim Abdelaal, Mohammed Charrout, Ahmed Mahfouz, Marcel J T Reinders, Stavros Makrodimitris
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292126 (2023)
Deep generative models, such as variational autoencoders (VAE), have gained increasing attention in computational biology due to their ability to capture complex data manifolds which subsequently can be used to achieve better performance in downstrea
Externí odkaz:
https://doaj.org/article/ec4dfa69d5814cc6ab46f4cf2ca68ce3
Autor:
Lianne M. Reus, Iris E. Jansen, Merel O. Mol, Fred van Ruissen, Jeroen van Rooij, Natasja M. van Schoor, Niccolò Tesi, Marcel J. T. Reinders, Martijn A. Huisman, Henne Holstege, Pieter Jelle Visser, Sterre C. M. de Boer, Marc Hulsman, Shahzad Ahmad, Najaf Amin, Andre G. Uitterlinden, Arfan Ikram, Cornelia M. van Duijn, Harro Seelaar, Inez H. G. B. Ramakers, Frans R. J. Verhey, Aad van der Lugt, Jurgen A. H. R. Claassen, Geert Jan Biessels, Peter Paul De Deyn, Philip Scheltens, Wiesje M. van der Flier, John C. van Swieten, Yolande A. L. Pijnenburg, Sven J. van der Lee
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD cannot be genetically explained yet and it is likely that there are still FTD risk loci to be discovered. Common variants have been identified with genom
Externí odkaz:
https://doaj.org/article/c590880938b54bc184c9ea16e2a476f4