Zobrazeno 1 - 10
of 59
pro vyhledávání: '"T. R. TYLER"'
Publikováno v:
Food and Chemical Toxicology. 39:877-886
The subchronic toxicity of n-butyl acetate (nBA), a common industrial solvent, was tested in rats in a 13-week inhalation study. Male and female Sprague-Dawley (SD) rats were exposed to concentrations of 0, 500, 1500 or 3000 ppm nBA for 6 h per day,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea16fe5281669c611639e12e00b202ed
https://doi.org/10.1016/s0278-6915(01)00021-7
https://doi.org/10.1016/s0278-6915(01)00021-7
Publikováno v:
Journal of Applied Toxicology. 20:463-469
An inhalation toxicity study was conducted with rats to examine the potential for amyl acetate vapor to produce alterations in nervous system structure and function following repeated exposure. The study was performed as part of a USEPA Toxic Substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9204a108eb04d59f791df78b0404049f
https://doi.org/10.1002/1099-1263(200011/12)20:6<463::aid-jat715>3.0.co
https://doi.org/10.1002/1099-1263(200011/12)20:6<463::aid-jat715>3.0.co
Autor:
Robert W. Kapp, Gary A. Wright, Jonathan Hurley, Heather D. Burleigh-Flayer, Christopher Bevan, Michael W. Gill, T. H. Gardiner, T. R. Tyler
Publikováno v:
Journal of Applied Toxicology. 18:373-381
In a previous subchronic neurotoxicity study, increases in motor activity were observed for female rats after 9 and 13 weeks of exposure to 5000 ppm of isopropanol vapor. The present study was conducted to evaluate the reproducibility of these effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9e0066afad6e557ae6b797b4dbebf71
https://doi.org/10.1002/(sici)1099-1263(1998090)18:5<373::aid-jat522>3.0.co
https://doi.org/10.1002/(sici)1099-1263(1998090)18:5<373::aid-jat522>3.0.co
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 17:19-37
Naturally bred New Zealand White rabbits, 22 does/group, were treated with triethylenetetramine (TETA; CAS No. 112-24-3) in water by occluded cutaneous application on gestational days (gd) 6-18,6 h/day, at a volume of 2.0 ml/animal (approximately 0.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::767bc68fa53819eb2219528935014636
https://doi.org/10.3109/15569529809049301
https://doi.org/10.3109/15569529809049301
Autor:
Hon-Wing Leung, T. R. Tyler
Publikováno v:
Journal of Applied Toxicology. 17:361-367
The metabolism and disposition of diethylenetriamine trihydrochloride (DETA⋅3HCl) were studied with regard to route of administration and dosage effects. Male Fischer 344 rats were administered 50 or 500 mg kg−1 of [1,2-14C]-DETA⋅3HCl orally or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c00d3035921502228c5f55c2bd9bd2ee
https://doi.org/10.1002/(sici)1099-1263(199711/12)17:6<361::aid-jat453>3.0.co
https://doi.org/10.1002/(sici)1099-1263(199711/12)17:6<361::aid-jat453>3.0.co
Publikováno v:
Inhalation Toxicology. 9:623-646
Aerosolized n -butyl acetate (n -BA) was reported to have an LC50 value of approximately 160 ppm in a study conducted by 3M at NOTOX. Six follow-up studies at three laboratories (BASF, BRRC, NOTOX) were conducted in an attempt to reproduce this value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e4733f60ebe013e70fc6b462f62c2f2
https://doi.org/10.1080/089583797198015
https://doi.org/10.1080/089583797198015
Autor:
Christopher Bevan, Thomas H. Gardiner, Gary A. Wright, Marcy I. Banton, T. R. Tyler, Robert W. Kapp
Publikováno v:
Regulatory Toxicology and Pharmacology. 23:183-192
The toxicity of isopropanol (IPA) has been extensively studied as a result of a Test Rule under Section 4 of the Toxic Substances Control Act. In general, the data showed that IPA has a low order of acute and chronic toxicity; does not produce advers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93abbef5372a9bfc6b36c34c705d93d2
https://doi.org/10.1006/rtph.1996.0042
https://doi.org/10.1006/rtph.1996.0042
Autor:
J. Hellwig, W. Mellert, K. Kuettler, B. D. Astill, D. Guest, R. L. Sielken, S. R. Murphy, T. R. Tyler, J. R. Hodgson, R. Gingell
Publikováno v:
Fundamental and Applied Toxicology. 31:29-41
2-Ethylhexanol (2EH) is a weak nongenotoxic hepatic peroxisome proliferator in the rat. It is a high-volume chemical intermediate in the preparation of the plasticizers bis-(2-ethylhexyl) adipate (DEHA), bis-(2-ethylhexyl) phthalate (DEHP), and tris-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40cf4693ce1a49b86ffa8b496d5344a
https://doi.org/10.1006/faat.1996.0073
https://doi.org/10.1006/faat.1996.0073
Autor:
J. R. Hodgson, R. Gingell, Chr. Gembardt, W. Mellert, K. Deckardt, S. R. Murphy, B. D. Astill, T. R. Tyler, D. Guest
Publikováno v:
Toxicological Sciences. 29:31-39
Data on the subchronic toxicity of 2-ethylhexanol (2EH) were required to establish the dose vehicle and dose levels for oncogenicity studies. In preliminary studies 2EH was given subacutely (11 days) to male and female Fischer 344 rats and B6C3F1 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f91ac97c5e2be42a7b7accaaad1ea4e
https://doi.org/10.1093/toxsci/29.1.31
https://doi.org/10.1093/toxsci/29.1.31
Autor:
M. B. Vinegar, Charles A. Mebus, R. W. Rickard, T. R. Tyler, T. C. Cascieri, F. M. B. Carpanini
Publikováno v:
Toxicological Sciences. 24:206-216
Vinyl acetate (VA) is a commonly used chemical in polymerization and copolymerization processes and as a chemical intermediate. As part of a collaborative effort between VA producers of the United States and British Petroleum, the present study was c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972634868a60641d1d31d9fbbd070cd4
https://doi.org/10.1093/toxsci/24.2.206
https://doi.org/10.1093/toxsci/24.2.206