Zobrazeno 1 - 10
of 18
pro vyhledávání: '"T. R. Sosnick"'
Experimental studies show that evolutionary information contained in an amino acid sequence is sufficient to specify functional positions and the tertiary structure of the protein. Statistical Coupling Analysis (SCA) and Direct-Coupling Analysis (DCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488132e8bc71205e29fe0877b678b58f
We describe an approach for predicting protein folding pathways and tertiary structure from a primary sequence. The method integrates our existing Monte Carlo Simulated Annealing (MCSA) TerItFix algorithm and Upside, a new continuous staEsEcal potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12291a0089cd2d38b3bf1c57c2fd79c9
Publikováno v:
Physical Review B. 43:216-228
Deep-inelastic-scattering measurements at high-momentum transfer Q can provide direct information on the momentum distribution of a system of particles if the impulse approximation (IA) is valid. In many such experiments, however, deviations between
Publikováno v:
Physical Review B. 41:11185-11202
Deep-inelastic neutron scattering measurements on liquid $^{4}\mathrm{He}$ have been carried out for temperatures from 0.35 to 4.2 K at a density of 0.147 g/${\mathrm{cm}}^{3}$. These measurements have a relative resolution comparable to previous rea
Publikováno v:
Physical Review B. 41:103-110
Deep inelastic neutron scattering measurements on normal liquid $^{4}\mathrm{He}$ at 4.25 K have been carried out at 11 densities between 0.125 (saturated vapor pressure) and 0.200 g/${\mathrm{cm}}^{3}$, at a momentum transfer of 23 A${\r{}}^{\mathrm
Autor:
B A, Krantz, T R, Sosnick
Publikováno v:
Nature structural biology. 8(12)
To address whether proteins fold along multiple pathways, i,i+4 bi-histidine metal binding sites are introduced into dimeric and crosslinked versions of the leucine zipper region of the growth control transcription factor, GCN4. Divalent metal ion bi
Publikováno v:
Biochemistry. 40(12)
The isothermal equilibrium folding of the unmodified yeast tRNA(Phe) is studied as a function of Na(+), Mg(2+), and urea concentration with hydroxyl radical protection, circular dichroism, and diethyl pyrocarbonate (DEPC) modification. These assays i
Autor:
B A, Krantz, T R, Sosnick
Publikováno v:
Biochemistry. 39(38)
Conflicting results exist regarding whether the folding of mammalian ubiquitin at 25 degrees C is a simple, two-state kinetic process or a more complex, three-state process with a defined kinetic intermediate. We have measured folding rate constants
Publikováno v:
Methods in enzymology. 317
Publikováno v:
Nature structural biology. 7(1)
We have exploited a procedure to identify when hydrogen bonds (H-bonds) form under two-state folding conditions using equilibrium and kinetic deuterium/hydrogen amide isotope effects. Deuteration decreases the stability of equine cytochrome c and the