Zobrazeno 1 - 10
of 21
pro vyhledávání: '"T. R. Santha Kumar"'
Autor:
Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and expo
Externí odkaz:
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
Autor:
Achuthanunni Chokkathukalam, David A. Fidock, Marco Biddau, T. R. Santha Kumar, Stephen L. Hoffman, Lewis J King, Larissa M. Laine, Graham H. Coombs, Geoffrey I. McFadden, Philipp P. Henrich, Michael P. Barrett, Kim Lee Sim, Gavin Blackburn, Tao Li, Lilach Sheiner, Sylke Müller
Publikováno v:
International Journal for Parasitology
Graphical abstract
Highlights • Apicoplast LipB deletion leads to changed antioxidant expression that precedes and coincides with accelerated differentiation. • 3D7 Plasmodium exhibits changes in glycolysis and tricarboxylic acid cycle activ
Highlights • Apicoplast LipB deletion leads to changed antioxidant expression that precedes and coincides with accelerated differentiation. • 3D7 Plasmodium exhibits changes in glycolysis and tricarboxylic acid cycle activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1af396c0cc1a2654b6cf40fde8641b1
https://doi.org/10.1016/j.ijpara.2020.10.011
https://doi.org/10.1016/j.ijpara.2020.10.011
Autor:
Jennifer A. Yang, Bing Yu Zou, Frances Rocamora, Edgar Vigil, Prianka Kumar, Nina F. Gnädig, Alan F. Cowman, David A. Fidock, Roy Williams, Trevor Johnson, Madeline R. Luth, Danushka S. Marapana, Dylan Hutson, Marcus C. S. Lee, Tilla S. Worgall, Jianbo Huang, Gregory M. Goldgof, Gregory LaMonte, T. R. Santha Kumar, Jennifer K. Thompson, Timothy J. Egan, Roxanne Mohunlal, Sabine Ottilie, Dionicio Siegel, Elizabeth A. Winzeler, Andrea L. Cheung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b18290350407667761814a3f37b90a3
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
Autor:
Jacquin C. Niles, Olalla Sanz, Anne-Catrin Uhlemann, Giulia Siciliano, Marcus C. S. Lee, Pietro Alano, Tomas Yeo, Michael J. Delves, Charisse Flerida A. Pasaje, Manuel Llinás, Sabine Ottilie, Louis Dwomoh, Kathryn J. Wicht, David A. Fidock, Megan J. Bird, Marla J. Giddins, Elizabeth A. Winzeler, Lauren B. Arendse, Nimisha Mittal, Emma F. Carpenter, T. R. Santha Kumar, Sonja Ghidelli-Disse, Natasha Spottiswoode, Sachel Mok, Edward Owen, Manu Vanaerschot, Kelly Chibale, James M. Murithi, Christian Doerig, Markus Bösche, Andrew B. Tobin
Publikováno v:
Cell Chemical Biology
Summary The search for antimalarial chemotypes with modes of action unrelated to existing drugs has intensified with the recent failure of first-line therapies across Southeast Asia. Here, we show that the trisubstituted imidazole MMV030084 potently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d625bae4a60074eb3597e6c742453db2
https://eprints.gla.ac.uk/216135/1/216135.pdf
https://eprints.gla.ac.uk/216135/1/216135.pdf
Autor:
Grazia Camarda, T. R. Santha Kumar, Roberta Bona, David A. Fidock, Andrea Cara, Giulia Siciliano, Katja Becker, Pietro Alano, Luca Cevenini, Elisabeth Davioud-Charvet, Maria Maddalena Calabretta
Publikováno v:
Molecular Microbiology. 104:306-318
The goal to prevent Plasmodium falciparum transmission from humans to mosquitoes requires the identification of targetable metabolic processes in the mature (stage V) gametocytes, the sexual stages circulating in the bloodstream. This task is complic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::299eb434eac99ac1d7d0196ee116791c
https://doi.org/10.1111/mmi.13626
https://doi.org/10.1111/mmi.13626
Autor:
Aldo Roda, Bruce R. Branchini, David A. Fidock, Pietro Alano, T. R. Santha Kumar, Maria Maddalena Calabretta, Andrea Cara, Giulia Siciliano, Luca Cevenini, Elisa Michelini, Roberta Bona, Grazia Camarda
Publikováno v:
Analytical Chemistry
New reliable and cost-effective antimalarial drug screening assays are urgently needed to identify drugs acting on different stages of the parasite Plasmodium falciparum, and particularly those responsible for human-to-mosquito transmission, that is,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b20f879537d1870574b915eb61fc1dc
http://europepmc.org/articles/PMC4151787
http://europepmc.org/articles/PMC4151787
Autor:
Leonardo Lucantoni, Caroline L. Ng, Philipp P. Henrich, Jill M. Combrinck, Kim Lee Sim, Robert E. Sinden, Sandra Duffy, Michael J. Delves, Stephen L. Hoffman, Elizabeth A. Winzeler, David A. Fidock, Pietro Alano, T. R. Santha Kumar, Vicky M. Avery, Kelly Rubiano, Giulia Siciliano, Tao Li, Ori J. Lieberman, Victoria C. Corey, Andrea Ruecker, Pedro Eduardo Ferreira, Sonia Gulati, M. Isabel Veiga, Timothy J. Egan, Manu Vanaerschot, James M. Murithi
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity
Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapi
Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc20a144b0135bf8227b2de13d145e16
https://hdl.handle.net/1822/48999
https://hdl.handle.net/1822/48999
Autor:
Belinda Joan Morahan, Nelly Camargo, Tao Li, Matt Fishbaugher, Mark Kennedy, Shahid M. Khan, Ben C. L. van Schaijk, Stephen L. Hoffman, David A. Fidock, Kim Lee Sim, Abraham G. Eappen, Chris J. Janse, Kim C. Williamson, Martijn W. Vos, T. R. Santha Kumar, Stefan H. I. Kappe, Ashley M. Vaughan, Robert W. Sauerwein, Geert-Jan van Gemert, Adam D. Richman
Publikováno v:
Eukaryotic Cell, 13(5), 550-559
Eukaryotic Cell, 13, 550-9
Eukaryotic Cell, 13, 5, pp. 550-9
Eukaryotic Cell, 13, 550-9
Eukaryotic Cell, 13, 5, pp. 550-9
The prodigious rate at which malaria parasites proliferate during asexual blood-stage replication, midgut sporozoite production, and intrahepatic development creates a substantial requirement for essential nutrients, including fatty acids that likely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4753b0b6b081c3f570e7fce2b125d31d
https://doi.org/10.1128/ec.00264-13
https://doi.org/10.1128/ec.00264-13
Autor:
Christina Deschermeier, David A. Fidock, Sonia Gulati, T. R. Santha Kumar, Brie Falkard, Krista Ann Matthews, Leonie Hecht, Philipp P. Henrich, Sean T. Prigge, Photini Sinnis, Rebecca E. Lewis, Volker Heussler, Micah J. Manary, Elizabeth A. Winzeler
Publikováno v:
Cellular Microbiology. 15:1585-1604
The successful navigation of malaria parasites through their life cycle, which alternates between vertebrate hosts and mosquito vectors, requires a complex interplay of metabolite synthesis and salvage pathways. Using the rodent parasite Plasmodium b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f079316d82f90674fcae22afecba9d78
https://doi.org/10.1111/cmi.12137
https://doi.org/10.1111/cmi.12137
Autor:
Guy A. Schiehser, T. R. Santha Kumar, James C. Sacchettini, John W. Anderson, Sean Ekins, Arba L. Ager, Han Chun Tsai, William R. Jacobs, Mack Kuo, David P. Jacobus, Jacek Terpinski, Joel S. Freundlich, David A. Fidock, Dimitri Sarantakis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1022-1025
Exploration of triclosan analogs has led to novel diaryl ureas with significant potency against in vitro cultures of drug-resistant and drug-sensitive strains of the human malaria parasite Plasmodium falciparum. Compound 18 demonstrated EC(50) values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2f88d4f025073854e5f99e80dcc75
https://doi.org/10.1016/j.bmcl.2012.12.022
https://doi.org/10.1016/j.bmcl.2012.12.022