Zobrazeno 1 - 10
of 29
pro vyhledávání: '"T. R. Rutherford"'
Autor:
C. E. D. Chilvers, P. J. Darbyshire, Malcolm Taylor, Judith C. W. Marsh, C. G. Geary, C. Harriss, Edward C. Gordon-Smith, Kenneth Muir, Matthew J. Grainge, T. R. Rutherford, Jill Hows, L. Coulson
Publikováno v:
British Journal of Haematology. 123:906-914
Aplastic anaemia is a rare but serious disorder with a high morbidity and mortality rate. The causes of aplastic anaemia are, for the most part, unknown. We report on the hypothesis that aplastic anaemia may be caused by occupational and/or environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a5392a124dfa4c6bbdbc8f56da6437
https://doi.org/10.1046/j.1365-2141.2003.04718.x
https://doi.org/10.1046/j.1365-2141.2003.04718.x
Autor:
Frances M. Gibson, T. R. Rutherford, M. Ismail, Gwen S. Draycott, Edward C. Gordon-Smith, K. Marks
Publikováno v:
Clinical & Laboratory Haematology. 24:329-335
In aplastic anaemia (AA), correction of bone marrow (BM) stromal function may contribute to the outcome of bone marrow transplantation (BMT). Engraftment of BM stromal cells is rarely observed, but engraftment of accessory cells (macrophages and T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6494fe47b287cd15215d5ddc0e9bab4
https://doi.org/10.1046/j.1365-2257.2002.00463.x
https://doi.org/10.1046/j.1365-2257.2002.00463.x
Autor:
M. Ismail, John Scopes, Frances M. Gibson, Edward C. Gordon-Smith, Christopher Pocock, Karen J. Marks, T. R. Rutherford, Gwen S. Draycott
Publikováno v:
British Journal of Haematology. 115:642-652
Defects in stromal cell function have been demonstrated in a number of aplastic anaemia (AA) patients. Here we have studied a patient with severe AA and abnormal stromal cell function who underwent bone marrow transplantation (BMT). The objective of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57bbb546567319d3c9fffaf358c171a5
https://doi.org/10.1046/j.1365-2141.2001.03134.x
https://doi.org/10.1046/j.1365-2141.2001.03134.x
Publikováno v:
British Journal of Haematology. 113:706-712
Aplastic anaemia (AA) is a syndrome of haemopoietic failure involving increased apoptosis in stem cells. AA CD34+ cells often have upregulated Fas antigen, but this does not explain the increased apoptosis in all patients. To examine whether abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51e352f51857740b6bbf3abf91b0db29
https://doi.org/10.1046/j.1365-2141.2001.02810.x
https://doi.org/10.1046/j.1365-2141.2001.02810.x
Publikováno v:
European Journal of Haematology. 64:385-395
Conflicting results have been published on the frequency of clonal patterns of X-chromosome inactivation in female patients with aplastic anaemia. Previous studies have used DNA methylation to measure X-inactivation, but aberrant methylation is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de624d91a6eb94d24ad0b810a195086b
https://doi.org/10.1034/j.1600-0609.2000.90150.x
https://doi.org/10.1034/j.1600-0609.2000.90150.x
Publikováno v:
Blood. 95:646-650
Long-term survivors of aplastic anemia (AA) have a high incidence of clonal disorders, in particular paroxysmal nocturnal hemoglobinuria (PNH), myelodysplastic syndromes (MDS), and acute nonlymphocytic leukemia. To investigate the potential involveme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268cc66f9e5588ba5cb1f18717244fc5
https://doi.org/10.1182/blood.v95.2.646
https://doi.org/10.1182/blood.v95.2.646
Publikováno v:
British Journal of Haematology. 96:240-247
Fanconi's anaemia (FA) is characterized by increased spontaneous and induced chromosome fragility. This has been widely regarded to be due to a defect in DNA crosslink repair, because of the sensitivity of cells to known DNA crosslinking agents such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ae9a4cfb8dc024b7670805afb0a74a
https://doi.org/10.1046/j.1365-2141.1997.d01-2023.x
https://doi.org/10.1046/j.1365-2141.1997.d01-2023.x
Publikováno v:
STEM CELLS. 12:180-186
The survival of human leukemic and normal progenitor cells was determined after cryopreservation. Thirteen marrows from patients with acute myeloid leukemia (AML) were studied as fresh and eight as cryopreserved samples. Marrows from five normal dono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872535d5fca30e55ec224e06ed982c69
https://doi.org/10.1002/stem.5530120206
https://doi.org/10.1002/stem.5530120206
Autor:
T. R. Rutherford, Jennifer A. Tooze, Borthwick-Clarke C, K. M. Josten, Edward C. Gordon-Smith
Publikováno v:
Blood. 78:3162-3167
DIOPATHIC, ACQUIRED aplastic anemia (AA) is a I failure of the hematopoietic system affecting multiple lineages. The pathogenesis is not understood, but may involve intrinsic failure of the hematopoietic stem cells, disturbance of the hematopoietic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162db451a1b5656f2b148c566c8d7e45
https://doi.org/10.1182/blood.v78.12.3162.3162
https://doi.org/10.1182/blood.v78.12.3162.3162
Autor:
T. R. Rutherford, John Scopes, Edward C. Gordon-Smith, Christopher Pocock, Gwen S. Draycott, S. Rizzo, Theodora Foukaneli, Frances M. Gibson
Publikováno v:
Experimental hematology. 32(7)
Objective Bone marrow from aplastic anemia (AA) patients shows reduced numbers in long-term culture (LTC)-initiating cell (LTC-IC) assays. The LTC-IC assay is based on assumptions of the culture kinetics of normal hematopoietic stem cells (HSC), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f47cccbddf6e5fdd8fedf9281ededf
https://pubmed.ncbi.nlm.nih.gov/15246163
https://pubmed.ncbi.nlm.nih.gov/15246163