Výsledky vyhledávání

The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages

Autor: Y W He, H Nakajima, W J Leonard, B Adkins, T R Malek

Publikováno v: The Journal of Immunology. 158:2592-2599

Signaling through the common gamma chain (gamma c), a subunit of the receptors for IL-2, -4, -7, -9, and -15, is critical for lymphocyte development, with the IL-7/IL-7R representing one important interaction. To investigate the stages of intrathymic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33c0c176cbd0dc9c5c043fbd9e0ad901
https://doi.org/10.4049/jimmunol.158.6.2592

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The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor

Autor: Y W He, T R Malek

Publikováno v: The Journal of Immunology. 155:9-12

The IL-2 receptor (IL-2R) gamma c subunit is also a component of the receptors for IL-4, IL-7, IL-9, and IL-15. The IL-4R and IL-13R appear to share a common subunit, and gamma c was proposed to be this shared subunit. In this study, we have assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25ecf42a03c17ffc99fa3ed3b571b5c9
https://doi.org/10.4049/jimmunol.155.1.9

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Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor

Autor: Y W He, B Adkins, R K Furse, T R Malek

Publikováno v: The Journal of Immunology. 154:1596-1605

IL-2R, IL-4R, and IL-7R share a common subunit referred to as gamma c and the IL-13R has been proposed to contain gamma c as a subunit. In this report we have used two novel mAbs (3E12 and 4G3) to distinct epitopes of mouse gamma c to determine its l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::683e86bfbecc04516df76d0482539d6c
https://doi.org/10.4049/jimmunol.154.4.1596

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Formation of high affinity IL-2 receptors is dependent on a nonligand binding region of the alpha subunit

Autor: N S Gutgsell, T R Malek

Publikováno v: The Journal of Immunology. 153:3899-3907

The IL-2R is composed of three subunits, alpha, beta, and gamma, each of which individually contributes to binding IL-2 in the high affinity IL-2R. The molecular mechanism by which the high affinity IL-2R assembles has not been established. Previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a42a9d477b85c0022ce6100e610478a
https://doi.org/10.4049/jimmunol.153.9.3899

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Multiple glycosylphosphatidylinositol-anchored Ly-6 molecules and transmembrane Ly-6E mediate inhibition of IL-2 production

Autor: T J Fleming, T R Malek

Publikováno v: The Journal of Immunology. 153:1955-1962

Cross-linking of Ly-6 molecules on T lymphocytes leads to IL-2 production, whereas costimulation of T cells via Ly-6A/E and the TCR inhibits IL-2 secretion. This study was initiated to determine whether there are unique structural requirements at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db83e3ec16a2e950789c2f41bd450b11
https://doi.org/10.4049/jimmunol.153.5.1955

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Subsets of activated CD4 T lymphocytes refractory for secretion of IL-2 are distinguished by expression of Ly-6A/E in BALB/c mice

Autor: E K Codias, T R Malek

Publikováno v: The Journal of Immunology. 151:5918-5929

Ly-6A/E, a cell surface glycosylphosphatidylinositol-anchored protein that modulates T cell activation, is expressed on developing and mature T cells and is tightly regulated in a haplotype- and subset-specific manner. We examined whether Ly-6A/E(low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c980fc3c17c7065059b6cbb0db9ee66
https://doi.org/10.4049/jimmunol.151.11.5918

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Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family

Autor: T J Fleming, M L Fleming, T R Malek

Publikováno v: The Journal of Immunology. 151:2399-2408

Mouse Ly-6 proteins are characterized by lineage-restricted patterns of expression on lymphoid cells. A mAb (1A8) was produced to Ly-6G, a newly described member of the Ly-6 locus. Based on selective reactivity to cloned Ly-6 gene products expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d3df84896c8984c1a149344f538f313
https://doi.org/10.4049/jimmunol.151.5.2399

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Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxins

Autor: T J Fleming, C O'hUigin, T R Malek

Publikováno v: The Journal of Immunology. 150:5379-5390

Genomic clones cross-hybridizing with Ly-6A.2 cDNA were isolated and characterized for functional Ly-6-related genes. Two new Ly-6 genes, designated Ly-6F.1 and Ly-6G.1, were found to have high nucleotide homology (> or = 70%) and the characteristic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::254aa8b9b023db81906f06b460baa6fa
https://doi.org/10.4049/jimmunol.150.12.5379

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Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway

Autor: E K Codias, T J Fleming, C M Zacharchuk, J D Ashwell, T R Malek

Publikováno v: The Journal of Immunology. 149:1825-1852

Ly-6A/E molecules were originally implicated in regulation of T cell activation because anti-Ly-6A/E mAb induce IL-2 production. More recently we have shown that anti-Ly-6A/E also inhibits IL-2 production induced by anti-CD3. In the present study we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61625712861807fab7dcc0dfecd686c8
https://doi.org/10.4049/jimmunol.149.6.1825

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Measurement of lymphokine receptors

Autor: J W, Lowenthal, T R, Malek, H, Saragovi

Publikováno v: Current protocols in immunology.

One of the most widely studied lymphokine systems is the T lymphocyte growth factor interleukin 2 (IL-2). This unit describes two basic methods for the quantitation and biochemical characterization of IL-2 receptors. The first method employs the radi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e337da6f9f97b71d877690a95885089f
https://pubmed.ncbi.nlm.nih.gov/18432801

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