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Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility*

Autor: Jeeva Sengottaiyan, Sivankutty Indu, Pradeep G. Kumar, Sathy M. Pillai, Sreeja C. Sekhar, Anil T. R. Kumar, Malini Laloraya

Publikováno v: Molecular & Cellular Proteomics. 14:3185-3195

DYNLT1 is a member of a gene family identified within the t-complex of the mouse, which has been linked with male germ cell development and function in the mouse and the fly. Though defects in the expression of this gene are associated with male ster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7e24938fd16adb959557c37229d5fc
https://doi.org/10.1074/mcp.m115.050005

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Pituitary gonadotrophic hormone synthesis, secretion, subunit gene expression and cell structure in normal and follicle-stimulating hormone beta knockout, follicle-stimulating hormone receptor knockout, luteinising hormone receptor knockout, hypogonadal and ovariectomised female mice

Autor: Ilpo Huhtaniemi, Helen C. Christian, M. H. Abel, X. Wang, A. Widen, T. R. Kumar, Pirjo Pakarinen

Publikováno v: Journal of Neuroendocrinology. 26(11):785-795

To investigate the relationship between gonadotroph function and ultrastructure, we have compared, in parallel in female mice, the effects of several different mutations that perturb the hypothalamic-pituitary-gonadal axis. Specifically, serum and pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01773f0e8faf1e592d7734451ed2cd8e
https://doi.org/10.1111/jne.12178

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An investigation into pituitary gonadotrophic hormone synthesis, secretion, subunit gene expression and cell structure in normal and mutant male mice

Autor: Ilpo Huhtaniemi, Helen C. Christian, T. R. Kumar, Harry M. Charlton, M. H. Abel, Pirjo Pakarinen

To investigate brain–pituitary–gonadal inter-relationships, we have compared the effects of mutations that perturb the hypothalamic–pituitary–gonadal axis in male mice. Specifically, serum and pituitary gonadotrophin concentrations, gonadotro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fa937389b83c01c7ead3afaa2c76fa
https://doi.org/10.1111/jne.12081

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Autoimmune Regulator (AIRE) Is Expressed in Spermatogenic Cells, and It Altered the Expression of Several Nucleic-Acid-Binding and Cytoskeletal Proteins in Germ Cell 1 Spermatogonial (GC1-spg) Cells*

Autor: Jeeva Sengottaiyan, Kongattu P. Bhagya, Karthika Radhakrishnan, Anil T. R. Kumar, Pradeep G. Kumar, A. N. Devi

Autoimmune regulator (AIRE) is a gene associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). AIRE is expressed heavily in the thymic epithelial cells and is involved in maintaining self-tolerance through regulating t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46dfd4a73843ea2e5cc83989def4e6b
https://europepmc.org/articles/PMC4974344/

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Optimization of warfarin dose by population-specific pharmacogenomic algorithm

Autor: Addepalli Pavani, Amaresh Rao Malempati, Yedluri Rupasree, Ramakrishna Pinjala, T R Kumar, Vijay Kumar Kutala, Ramesh Chandra Mishra, Shaik Mohammad Naushad

Publikováno v: The Pharmacogenomics Journal. 12:306-311

To optimize the warfarin dose, a population-specific pharmacogenomic algorithm was developed using multiple linear regression model with vitamin K intake and cytochrome P450 IIC polypeptide9 (CYP2C9(*)2 and (*)3), vitamin K epoxide reductase complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b30d4bd1291a3953682a1774c8b051b
https://doi.org/10.1038/tpj.2011.4

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Reproductive Defects in γ-Glutamyl Transpeptidase-Deficient Mice1

Autor: Amy L. Wiseman, Subbarao V. Kala, Geeta Kala, Martin M. Matzuk, Michael W. Lieberman, T R Kumar

Publikováno v: Endocrinology. 141:4270-4277

Mice deficient in γ-glutamyl transpeptidase (GGT) are growth retarded as a result of cysteine deficiency secondary to excessive glutathione excretion in urine and display coat color defects and cataracts. Although GGT is widely expressed throughout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5da05e9dc86d1f53be662919158b58a9
https://doi.org/10.1210/endo.141.11.7760

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Follistatin Is a Modulator of Gonadal Tumor Progression and the Activin-Induced Wasting Syndrome in Inhibin-Deficient Mice1

Autor: Martin M. Matzuk, L Chen, S C Cipriano, T R Kumar

Publikováno v: Endocrinology. 141:2319-2327

Inhibins and activins are dimeric proteins belonging to the transforming growth factor-beta superfamily. Follistatin is an activin-binding protein that antagonizes the function of activin via binding to its beta-subunits. Previously, we demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c44f992c90c28622e0bd41ca88cb494c
https://doi.org/10.1210/endo.141.7.7535

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Growth differentiation factor-9 is required during early ovarian folliculogenesis

Autor: N Lu, T R Kumar, David F. Albertini, Martin M. Matzuk, Katsuhiko Nishimori, Dong J

Publikováno v: Nature. 383:531-535

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function, but it is unclear whether oocyte-secreted factors play a reciprocal role in modulating somatic cell functions in vivo. During the functional analysis of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475f199cb4d1fa29a8752040bb74d843
https://doi.org/10.1038/383531a0

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