Výsledky vyhledávání - "T. R. Kershaw"

Neuropathological Sequelae of Long-Term Allogeneic and Syngeneic Neural Transplantation into the Hippocampus

Autor: Sanjay N. Patel, John Williams, John Sinden, T. R. Kershaw, Peter L. Lantos, Jeffrey A. Gray

Publikováno v: Journal of Neural Transplantation & Plasticity

The long-term fate of multiple intrahippocampal allogeneic transplants of fetal basal forebrain tissue was studied in neonatally tolerised and immunised groups of rats with lesions of the fimbria-fornix. Despite the good survival of the allografts in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608a8c32464769330ffd0b53c1b8c98f
https://doi.org/10.1155/np.1994.211

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Foetal grafts from hippocampal regio superior alleviate ischaemic-induced behavioral deficits

Autor: Helen Hodges, T. R. Kershaw, Jeffrey A. Gray, Carlos Alexandre Netto, John Sinden, Peter Sowinski, Eliane LePeillet, Brian S. Meldrum

Publikováno v: Behavioural Brain Research. 58:107-112

Transitory global cerebral ischaemia produced in rats by four vessel occlusion for 15 min produced substantial loss of CA1 cells in dorsal hippocampus and minimal other intra- and extra-hippocampal damage. Ischaemic rats showed a long-lasting impairm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7033fe3f0e2760c12c2d18c5a7a6882d
https://doi.org/10.1016/0166-4328(93)90095-8

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Functional reconstruction of the hippocampus: fetal versus conditionally immortal neuroepithelial stem cell grafts

Autor: H, Hodges, P, Sowinski, D, Virley, A, Nelson, T R, Kershaw, W P, Watson, T, Veizovic, S, Patel, A, Mora, T, Rashid, S J, French, A, Chadwick, J A, Gray, J D, Sinden

Publikováno v: Novartis Foundation symposium. 231

Late fetal CA1 hippocampal grafts and stem cell grafts from the conditionally immortal MHP36 clonal line derived from the H-2Kb-tsA58 transgenic mouse neuroepithelium both improved spatial deficits in rats with ischaemic CA1 damage induced by four-ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a78cc8a2f3bf50f72bef9a0f32c31a7
https://pubmed.ncbi.nlm.nih.gov/11131545

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Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field

Autor: S. J. French, Peter L. Lantos, John Sinden, Spencer Harland, Peter Sowinski, Helen Hodges, T. R. Kershaw, Rosalind M. Ridley, Tahira Rashid, Jeffrey A. Gray, David Virley

Publikováno v: Brain : a journal of neurology. 122

Common marmosets (Callithrix jacchus, n = 18) were trained to discriminate between rewarded and non-rewarded objects (simple discriminations, SDs) and to make conditional discriminations (CDs) when presented sequentially with two different pairs of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0b1f8765bd4c4c9a9e86e75ab6de21
https://pubmed.ncbi.nlm.nih.gov/10581225

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Learning impairment induced by lesion of the CA1 field of the primate hippocampus: attempts to ameliorate the impairment by transplantation of fetal CA1 tissue

Autor: Helen Hodges, C. Pearson, Rosalind M. Ridley, Harry F. Baker, T. R. Kershaw, C. J. Maclean, C. Hoyle

Publikováno v: Experimental brain research. 115(1)

Monkeys with bilateral excitotoxic lesion of the CA1 field of the hippocampus were severely impaired at learning visuospatial conditional tasks. This was not a general spatial impairment, because the animals were not impaired on serial spatial revers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2972417c48cad1dcedf1b2ff8bd74d03
https://pubmed.ncbi.nlm.nih.gov/9224836

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Astrocyte transplants alleviate lesion induced memory deficits independently of cholinergic recovery

Autor: R. M. Marchbanks, T. R. Kershaw, Elizabeth J. Bradbury, J. D. Sinden

Publikováno v: King's College London

Basal forebrain tissue fragments taken from embryonic day 15 were separated into primary astrocytes and primary neurons in culture and grafted to rats with alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid lesions to the nucleus basalis and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffa8da12e931c845d974c9dd25cd964
https://pubmed.ncbi.nlm.nih.gov/7542374

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Neuropathological Changes and Abnormal RT97 Staining of Neurofilaments in the Host Hippocampus, One Year After Intrahippocampal Transplantation

Autor: S. N. Patel, J. D. Sinden, T. R. Kershaw

Publikováno v: Journal of Neural Transplantation & Plasticity

We report here several neuropathological alterations in the host brain one year after the placement of intrahippocampal neural allografts of cholinergic-rich basal forebrain tissue in fimbria-fornix lesioned rats. The immunological reaction against t

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