Zobrazeno 1 - 10 of 20 pro vyhledávání: '"T. R. D. J. Radstake"'
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Akademický článek
Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients
Autor: A. Ottria, A. T. Hoekstra, M. Zimmermann, M. van der Kroef, N. Vazirpanah, M. Cossu, E. Chouri, M. Rossato, L. Beretta, R. G. Tieland, C. G. K. Wichers, E. Stigter, C. Gulersonmez, F. Bonte-Mineur, C. R. Berkers, T. R. D. J. Radstake, W. Marut
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Systemic sclerosis (SSc) is a rare chronic disease of unknown pathogenesis characterized by fibrosis of the skin and internal organs, vascular alteration, and dysregulation of the immune system. In order to better understand the immune system and its
Externí odkaz: https://doaj.org/article/74bc75512ca1480199aa5de734e43fe0
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2
Akademický článek
A System Out of Breath: How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis
Autor: T. W. van Hal, L. van Bon, T. R. D. J. Radstake
Publikováno v: International Journal of Rheumatology, Vol 2011 (2011)
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular alterations and immunological disturbances and fibrosis, the order of which remains to be fully determined. Clinically, patients show clear signs of hypoxia in skin and inter
Externí odkaz: https://doaj.org/article/48bd876f2a49430da14bc16115623b72
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3
Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4
Autor: N H, Servaas, F, Zaaraoui-Boutahar, C G K, Wichers, A, Ottria, E, Chouri, A J, Affandi, S, Silva-Cardoso, M, van der Kroef, T, Carvalheiro, F, van Wijk, T R D J, Radstake, A C, Andeweg, A, Pandit
Publikováno v: Journal of autoimmunity. 117
The T-cell receptor (TCR) is a highly polymorphic surface receptor that allows T-cells to recognize antigenic peptides presented on the major histocompatibility complex (MHC). Changes in the TCR repertoire have been observed in several autoimmune con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5a6f489734b2abbc68ce00b404216d3
https://pubmed.ncbi.nlm.nih.gov/33307312
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4
S5A:5 Galectin-9 is produced by dendritic cells and serum levels outperform cxcl10 as a biomarker to detect the ifn signature in sle and aps
Autor: Jag van Roon, T R D J Radstake, L.L. van den Hoogen, Rde Fritsch-Stork, Judith Wienke, F van Wijk
Publikováno v: S5a – Biomarker & indices.
Objective The most prominent alteration in the immune system of patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) is the increased expression of type I interferon (IFN) inducible genes, known as the IFN signature. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24b4278a935ccacb97bba31e93e83c23
https://doi.org/10.1136/lupus-2018-abstract.28
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5
PS5:91 Increased expression of tlr7 in plasmacytoid dendritic cells drives type i ifn mediated immunopathology in sle and aps
Autor: G Palla, T R D J Radstake, L.L. van den Hoogen, M Rossato, Rde Fritsch-Stork, Aridaman Pandit, Jag van Roon
Publikováno v: Poster session 5: Innate and adaptive immunity.
Background/purpose Dendritic cells (DC) are key cells in the pathogenesis of autoimmune diseases by potently activating T-cells. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are characterised by an IFN signature, caused by e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::545f3ae8868b5d03d6add6873313eb74
https://doi.org/10.1136/lupus-2018-abstract.136
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8
Targeting CD1c-expressing classical dendritic cells to prevent thymus and activation-regulated chemokine (TARC)-mediated T-cell chemotaxis in rheumatoid arthritis
Autor: Jag van Roon, Kmg M G van der Wurff-Jacobs, C. E. Hack, F. M. Moret, Maarten R Hillen, Fpjg P J G Lafeber, T R D J Radstake
Publikováno v: Scandinavian Journal of Rheumatology, 46(1), 11. Informa Healthcare
Objectives: Thymus and activation-regulated chemokine (TARC) attracts cells that express the C-C chemokine receptor type 4 (CCR4), including CD4 T cells. As expression of CCR4 is increased on peripheral T cells and intra-articular interleukin (IL)-17
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b824ebfbfaa24cc928fedb8ffee5a467
https://pubmed.ncbi.nlm.nih.gov/27250804
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10
Optimizing conventional DMARD therapy for Sjögren's syndrome
Autor: Aike A. Kruize, J A G van Roon, T R D J Radstake, E.H.M. van der Heijden
Publikováno v: Autoimmunity Reviews, 17(5), 480. Elsevier
Primary Sjogren's syndrome (pSS) is an auto immune disorder characterized by exocrine dysfunction as a result of chronic inflammation of the glands. Part of the patients also develops inflammation in other organs. In a complex interplay of different
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4550e3ecf2f3543b3cf9a52cc1dc62d1
https://hdl.handle.net/1874/364717
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