Zobrazeno 1 - 10
of 32
pro vyhledávání: '"T. R. Browne"'
Autor:
T R, Browne, G L, Holmes
Publikováno v:
New England Journal of Medicine. 344:1145-1151
Publikováno v:
The Journal of Clinical Pharmacology. 40:590-595
Levetiracetam has recently been approved as an adjunctive medication for partial seizures and frequently will be added to phenytoin. The objective of this study was to determine the presence or absence of a pharmacokinetic drug interaction of levetir
Publikováno v:
Journal of clinical pharmacology. 40(6)
Levetiracetam has recently been approved as an adjunctive medication for partial seizures and frequently will be added to phenytoin. The objective of this study was to determine the presence or absence of a pharmacokinetic drug interaction of levetir
Autor:
T R, Browne
Publikováno v:
Epilepsy research. Supplement. 10
Publikováno v:
Journal of clinical pharmacology. 32(12)
The authors show that for a drug cleared by one enzyme the area under the serum concentration-time curve from time 0 to infinity (AUC0-INF) of a test dose can be expressed as AUC0-INF = TD x F x (Km + C)/Vmax where TD is test dose size, F is fraction
Publikováno v:
Journal of clinical pharmacology. 32(6)
Publikováno v:
Biochemical pharmacology.
Clinical studies suggest that carbamazepine may attenuate effects of alprazolam discontinuation. Since discontinuation of chronic alprazolam in a mouse model is associated with behavioral alterations and upregulation at the gamma-aminobutyric acidA (
Publikováno v:
Therapeutic drug monitoring. 13(4)
A retrospective analysis of Veterans Administration (VA) Cooperative Study No. 118 was conducted to examine the relationship between serum phenytoin concentration (SPC) and various measures of patient response in 111 patients on monotherapy, mostly a
Autor:
T R, Browne
Publikováno v:
Neurology. 40(5 Suppl 2)
A thorough understanding of the pharmacologic properties of lipid-soluble drugs is essential when using these agents to treat status epilepticus. In addition to physiologic factors, such as blood pressure and cerebral blood flow, pharmacokinetic prin