Zobrazeno 1 - 10
of 356
pro vyhledávání: '"T. Pappas"'
Publikováno v:
HemaSphere, Vol 6, Pp 2172-2173 (2022)
Externí odkaz:
https://doaj.org/article/1ed01d9bdb6d4dfab22047a3182d6c46
Autor:
Jessika B. Iwanski, Christopher T. Pappas, Rachel M. Mayfield, Gerrie P. Farman, Rebecca Ahrens-Nicklas, Jared M. Churko, Carol C. Gregorio
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-21 (2024)
Abstract Neonatal dilated cardiomyopathy (DCM) is a poorly understood muscular disease of the heart. Several homozygous biallelic variants in LMOD2, the gene encoding the actin-binding protein Leiomodin 2, have been identified to result in severe DCM
Externí odkaz:
https://doaj.org/article/d3e3b84a14fb40d49e229be1589d0e31
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011279 (2024)
The leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function, highlighted by the fact that mutations in all three family members (LMOD1-3) result in human myopathies. Mutations in the cardiac predominant isoform, LMOD
Externí odkaz:
https://doaj.org/article/d1c4262a10d6440d8adc1049377bcc5b
Autor:
Lei Mi-Mi, Gerrie P Farman, Rachel M Mayfield, Joshua Strom, Miensheng Chu, Christopher T Pappas, Carol C Gregorio
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226138 (2020)
A novel cardiac-specific transgenic mouse model was generated to identify the physiological consequences of elongated thin filaments during post-natal development in the heart. Remarkably, increasing the expression levels in vivo of just one sarcomer
Externí odkaz:
https://doaj.org/article/2d90ecf9462448239a0553f27833ccd2
Akademický článek
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Recently, artificial neural networks have been gaining momentum in the field of gravitational wave astronomy, for example in surrogate modelling of computationally expensive waveform models for binary black hole inspiral and merger. Surrogate modelli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::e54d42e2f35c5f8f697cf52b352a4db8
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3219279
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3219279
Autor:
Michaela Yuen, Lisa Worgan, Jessika Iwanski, Christopher T. Pappas, Himanshu Joshi, Jared M. Churko, Susan Arbuckle, Edwin P. Kirk, Ying Zhu, Tony Roscioli, Carol C. Gregorio, Sandra T. Cooper
Publikováno v:
European journal of human genetics : EJHG. 30(4)
Dilated cardiomyopathy (DCM) is characterized by cardiac enlargement and impaired ventricular contractility leading to heart failure. A single report identified variants in leiomodin-2 (LMOD2) as a cause of neonatally-lethal DCM. Here, we describe tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6dd1a3e2ed80f1758b545dead4aa70
https://pubmed.ncbi.nlm.nih.gov/35082396
https://pubmed.ncbi.nlm.nih.gov/35082396
Akademický článek
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The main fault of economic system is the systemic poverty. In the systemic poverty there is no lack of goods and services but lack of the right to access them (money). The systemic poverty is increasing. In UK the recent (2021) direct poverty is 17%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10561::3710df42cd49db7f6a913a4cfabd2f90
https://olympias.lib.uoi.gr/jspui/handle/123456789/31904
https://olympias.lib.uoi.gr/jspui/handle/123456789/31904
Autor:
Christopher T. Pappas, Vitold E. Galkin, William Schlecht, Alla S. Kostyukova, Thu Ly, Wen-Ji Dong, Dylan Johnson, Mert Colpan, Carol C. Gregorio
Publikováno v:
Molecular Biology of the Cell
Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. Tropomyosin, together with the troponin complex, regulates muscle contraction and, along w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf79e45f7b4893051ef004d4eb905dc
https://doi.org/10.1091/mbc.e18-06-0406
https://doi.org/10.1091/mbc.e18-06-0406