Zobrazeno 1 - 10
of 27
pro vyhledávání: '"T. O. Nielsen"'
Autor:
Alister D'Costa, Cindy Q. Yao, Mitch Levine, M-A Quintayo, Melanie Spears, T. O. Nielsen, Chris Twelves, Jms Bartlett, Nicola Lyttle, Jane Bayani, Lois E. Shepherd, Linda Liao, KI Pritchard, Elizabeth N. Kornaga, Paul C. Boutros
Publikováno v:
Cancer Research. 78:P2-10
Background: The use of anthracycline-based chemotherapies has improved overall and disease free survival in breast cancer. However, anthracyclines can have significant toxicities including cardiotoxicity and leukemia. It is, therefore, imperative to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b09bddc35cc4ed0582ba6af4b52802e2
https://doi.org/10.1158/1538-7445.sabcs17-p2-10-01
https://doi.org/10.1158/1538-7445.sabcs17-p2-10-01
Autor:
T. O. Nielsen, Shuzhen Liu, S Leung, Zuzana Kos, Dongxia Gao, Bingshu E. Chen, Shakeel Virk, S Burugu, Karen A. Gelmon, Wendy R. Parulekar, Lois E. Shepherd
Publikováno v:
Cancer Research. 77:P1-09
Background and Objectives: The presence of tumor infiltrating lymphocytes (TILs), particularly CD8+ cytotoxic T-cells, has been associated with improved prognosis in patients with HER2+ breast cancer. Increasing levels of TILs also appear to predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99373e281eb10a57cedb5d0b4942ed1f
https://doi.org/10.1158/1538-7445.sabcs16-p1-09-08
https://doi.org/10.1158/1538-7445.sabcs16-p1-09-08
Autor:
M, Gnant, M, Filipits, R, Greil, H, Stoeger, M, Rudas, Z, Bago-Horvath, B, Mlineritsch, W, Kwasny, M, Knauer, C, Singer, R, Jakesz, P, Dubsky, F, Fitzal, R, Bartsch, G, Steger, M, Balic, S, Ressler, J W, Cowens, J, Storhoff, S, Ferree, C, Schaper, S, Liu, C, Fesl, T O, Nielsen, Peggy, Tsang
Publikováno v:
Annals of Oncology. 25:339-345
PAM50 is a 50-gene test that is designed to identify intrinsic breast cancer subtypes and generate a Risk of Recurrence (ROR) score. It has been developed to be carried out in qualified routine hospital pathology laboratories.One thousand four hundre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5269753483edc4444907447a5af6b89
https://doi.org/10.1093/annonc/mdt494
https://doi.org/10.1093/annonc/mdt494
Autor:
Arvydas Laurinavicius, Martin C. Chang, Vasiliki Pelekanou, Abhi Gholap, B. van der Vegt, David L. Rimm, Sandra Martinez-Morilla, Richard M. Levenson, T. O. Nielsen, A. Todd, Gilbert Bigras, Anagha P. Jadhav, Renaldas Augulis, Shakeel Virk, Judith Hugh, Maria I. Toki, Daniel F. Hayes, S Leung, Mitchell Dowsett, Balazs Acs, Yalai Bai, T Piper
Publikováno v:
Cancer Research. 79:P4-02
Background/Goal: Ki67 expression has been a valuable prognostic marker in breast cancer, but has not seen broad adoption due to lack of standardization between institutions. Automation could represent a solution. Here we tested 3 automated digital im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b150780017043389cac04d588033f0e6
https://doi.org/10.1158/1538-7445.sabcs18-p4-02-01
https://doi.org/10.1158/1538-7445.sabcs18-p4-02-01
Autor:
Dorte Nielsen, Brett Wallden, Karsten Bjerre, Clt Jørgensen, Shuzhen Liu, Eva Balslev, T. O. Nielsen, Bent Ejlertsen
Publikováno v:
Cancer Research. 72:P3-06
Background: Breast cancer can be subclassified into luminal A and B, basal-like and HER2-enriched subtypes, each with distinct biology, prognosis and response to therapy. Pre-clinical studies have suggested that a basal-like subtype is associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a232be9db9a66a02516872f955143040
https://doi.org/10.1158/0008-5472.sabcs12-p3-06-03
https://doi.org/10.1158/0008-5472.sabcs12-p3-06-03
Autor:
Scott Tyldesley, Mcu Cheang, Caroline Speers, T. O. Nielsen, Karen A. Gelmon, D. Voduc, Stephen Chia
Publikováno v:
Cancer Research. 72:P4-16
Background: Between 1978–1986, 318 premenopausal women treated with mastectomy for lymph node positive breast cancer, were randomized to CMF chemotherapy alone vs. CMF chemotherapy and adjuvant radiotherapy (RT) to the chest wall and regional lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5899a6ee8aada7f059134d0656f490e9
https://doi.org/10.1158/0008-5472.sabcs12-p4-16-02
https://doi.org/10.1158/0008-5472.sabcs12-p4-16-02
Autor:
Angel Arnaout, B. Dong, Mark Clemons, Karen A. Gelmon, T. O. Nielsen, J-Aw Chapman, Vivien H.C. Bramwell, Timothy J. Whelan, KI Pritchard, Rinat Yerushalmi, John Hilton, Nathaniel Bouganim, Frances P O'Malley, Lois E. Shepherd, Mitch Levine
Publikováno v:
Cancer Research. 71:P2-12
Background A common clinical conundrum in breast cancer management is whether pathologic T stage in women with multicentric or multifocal disease should be taken as the diameter of the largest focus or as the sum of all foci in the breast. Most stagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5646bda74960c34d8bf1531c90eedd2a
https://doi.org/10.1158/0008-5472.sabcs11-p2-12-23
https://doi.org/10.1158/0008-5472.sabcs11-p2-12-23
Autor:
Bent Ejlertsen, T. O. Nielsen, Eva Balslev, Dongsheng Tu, Annette Bartels, M.B. Jensen, Lois E. Shepherd, Kathleen I. Pritchard, P. B. Hertel, Nils Brünner, Frances P O'Malley, S. Jiang
Publikováno v:
Cancer Research. 71:P1-06
Purpose: HER2 amplification, TOP2A aberrations and absence of TIMP-1 (Tissue Inhibitor of Metalloproteinase-1) expression in breast carcinomas have been associated with incremental benefit from anthracycline-containing adjuvant chemotherapy in severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40e092cde1c40f9f87b06dd282e98842
https://doi.org/10.1158/0008-5472.sabcs11-p1-06-07
https://doi.org/10.1158/0008-5472.sabcs11-p1-06-07
Autor:
Mark Clemons, Karen A. Gelmon, Vivien H.C. Bramwell, Frances P O'Malley, Angel Arnaout, T. O. Nielsen, John Hilton, Kathleen I. Pritchard, Mitch Levine, Nathaniel Bouganim, Rinat Yerushalmi, B. Dong, Lois E. Shepherd, Timothy J. Whelan, J-Aw Chapman
Publikováno v:
Cancer Research. 71:P2-12
Background: A common clinical conundrum in breast cancer management is whether pathologic T stage in women with multicentric or multifocal disease should be taken as the diameter of the largest focus or as the sum of all foci in the breast. Most stag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f11b139490236c44a710eb1cdd2621
https://doi.org/10.1158/0008-5472.sabcs11-p2-12-27
https://doi.org/10.1158/0008-5472.sabcs11-p2-12-27
Autor:
A. Le Maitre, Stephen Chia, P. S. Bernard, Matthew J. Ellis, T. O. Nielsen, Lois E. Shepherd, Kathleen I. Pritchard, Vivien H.C. Bramwell, Karen A. Gelmon, J-Aw Chapman
Publikováno v:
Cancer Research. 70:P2-09
Background: Inter-laboratory comparability of ER and PR assay results has been problematic for decades. Statistical standardization has been proposed as an adjunct following good laboratory quality control. We demonstrate this process for ER and PR c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e9299aca2d91dfd94c27f403e1d462
https://doi.org/10.1158/0008-5472.sabcs10-p2-09-16
https://doi.org/10.1158/0008-5472.sabcs10-p2-09-16