Zobrazeno 1 - 10 of 12 pro vyhledávání: '"T. O. Eloranta"'
2
Polyamine-dependent alterations in the structure of microfilaments, Golgi apparatus, endoplasmic reticulum, and proteoglycan synthesis in BHK cells
Autor: J J, Parkkinen, M J, Lammi, U, Agren, M, Tammi, T A, Keinänen, T, Hyvönen, T O, Eloranta
Publikováno v: Journal of cellular biochemistry. 66(2)
The activity of ornithine decarboxylase, the key enzyme in the synthesis of polyamines, is essential for proliferation and differentiation of all living cells. Two inhibitors of ornithine decarboxylase, alpha-difluoromethylornithine (DFMO) and 1-amin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::807a4717b743cb16c518e0fbeeecbffb
https://pubmed.ncbi.nlm.nih.gov/9213218
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3
[New aminooxy analogs of biogenic polyamines]
Autor: A R, Khomutov, A S, Shvetsov, J, Vepsalainen, D L, Dramer, T, Hyvonen, T, Keinanen, T O, Eloranta, C W, Porter, R M, Khomutov
Publikováno v: Bioorganicheskaia khimiia. 22(7)
A series of structural analogs of putrescine, spermidine, and spermine with the aminomethylene fragment substituted by the aminooxy group was suggested. The synthesis of the new aminooxy analogs of spermine was described. Biochemical aspects of the a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f6fd74e0dd3b5a4f4a4f476642640ed
https://pubmed.ncbi.nlm.nih.gov/8992962
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4
Derivatives of 1-aminooxy-3-aminopropane as polyamine antimetabolites: stability and effects on BHK21/C13 cells
Autor: T A, Keinänen, T, Hyvönen, M C, Pankaskie, J J, Vepsäläinen, T O, Eloranta
Publikováno v: Journal of biochemistry. 116(5)
1- or 3-methylated derivatives and oximes of 1-aminooxy-3-aminopropane (APA) with pyridoxal (PL) and pyridoxal 5'-phosphate (PLP) were synthesized to examine whether the stability of the parent APA molecule could be increased without loss of its inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9501fd75f0b9db66dea061f0caf953b6
https://pubmed.ncbi.nlm.nih.gov/7896733
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5
Differential effects of sepsis and trauma on urinary excretion of polyamines
Autor: M J, Pöyhönen, J A, Takala, O, Pitkänen, A, Kari, L A, Alakuijala, T O, Eloranta
Publikováno v: Nutrition (Burbank, Los Angeles County, Calif.). 9(5)
Urinary excretion of polyamines increases in patients with trauma and infection. To separate the effect of infection from the general metabolic response to sepsis, we studied 7 patients with sepsis and 13 patients with multiple trauma in the intensiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6a960fd6fdf42ec79a0e2c0e297fc7d
https://pubmed.ncbi.nlm.nih.gov/8286878
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7
Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity
Autor: T O, Eloranta, A R, Khomutov, R M, Khomutov, T, Hyvönen
Publikováno v: Journal of biochemistry. 108(4)
Aminooxy analogues of spermidine, 1-aminooxy-3-N-[3-aminopropyl]- aminopropane (AP-APA) and N-[2-aminooxyethyl]-1,4-diaminobutane (AOE-PU), were tested as substrates or inhibitors of the enzymes involved in methionine and polyamine metabolism. Both c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ebe990c4ec56aeb400f585a86e5cba4
https://pubmed.ncbi.nlm.nih.gov/2292587
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8
Uptake of 3H-labeled 1-aminooxy-3-aminopropane by baby hamster kidney cells
Autor: T, Hyvönen, A R, Khomutov, R M, Khomutov, S, Lapinjoki, T O, Eloranta
Publikováno v: Journal of biochemistry. 107(6)
The uptake, catabolism, and release of H-labeled 1-aminooxy-3-aminopropane, a new putrescine analog shown to be a potent polyamine antimetabolite, into and from baby hamster kidney cells (BHK21/C13) were studied. The results show that [3H]-1-aminooxy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad275c8cedd8816a2cc2081435c0a988
https://pubmed.ncbi.nlm.nih.gov/2118137
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9
Regulation of S-adenosyl-L-methionine decarboxylase by 1-aminooxy-3-aminopropane: enzyme kinetics and effects on the enzyme activity in cultured cells
Autor: T, Hyvönen, T O, Eloranta
Publikováno v: Journal of biochemistry. 107(3)
The kinetics of inactivation of adenosylmethionine decarboxylase of rat liver and of baby hamster kidney cells (BHK21/C31) by 1-aminooxy-3-aminopropane was studied. The apparent dissociation constants (Ki) for the hepatic and BHK21/C13 enzymes were 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be06305cf043eba7d9f04e0d81c7ed87
https://pubmed.ncbi.nlm.nih.gov/2341368
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10
Catabolism and lability of S-adenosyl-l-methionine in rat liver extracts
Autor: E O Kajander, T O Eloranta
Publikováno v: Biochemical Journal. 224:137-144
The fate of S-adenosyl-L-methionine was studied in rat liver extracts by analysing the distribution of radioactivity from labelled adenosylmethionine in decomposition products, which were separated from each other by chromatographic and electrophoret
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a89e2415e8a23a955c1561944a3111
https://doi.org/10.1042/bj2240137
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