Zobrazeno 1 - 10 of 228 pro vyhledávání: '"T. O'Flaherty"'
1
Akademický článek
Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer
Autor: Yunping Hu, Haiguo Sun, Rick T. Owens, Zhennan Gu, Jansheng Wu, Yong Q. Chen, Joseph T. O'Flaherty, Iris J. Edwards
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 10, Pp 826-836 (2010)
Evidence indicates that diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFAs) reduce the risk of prostate cancer, but biochemical mechanisms are unclear. Syndecan-1 (SDC-1), a transmembrane heparan sulfate proteoglycan, supports the integrity
Externí odkaz: https://doaj.org/article/cd2c1cc3e26d4082bc3039a8fbd69a41
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2
Akademický článek
Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways
Autor: Yunping Hu, Haiguo Sun, Rick T. Owens, Jiansheng Wu, Yong Q. Chen, Isabelle M. Berquin, Donna Perry, Joseph T. O'Flaherty, Iris J. Edwards
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 10, Pp 1042-1053 (2009)
Epidermal growth factor receptor (EGFR) and androgen receptor (AR) pathways play pivotal roles in prostate cancer progression. Therefore, agents with dual-targeting ability may have important therapeutic potential. Decorin, a proteoglycan present in
Externí odkaz: https://doaj.org/article/ef65541785d046ef8f907e8c77f76205
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3
Akademický článek
Fatty acid metabolites in rapidly proliferating breast cancer.
Autor: Joseph T O'Flaherty, Rhonda E Wooten, Michael P Samuel, Michael J Thomas, Edward A Levine, L Douglas Case, Steven A Akman, Iris J Edwards
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63076 (2013)
Breast cancers that over-express a lipoxygenase or cyclooxygenase are associated with poor survival possibly because they overproduce metabolites that alter the cancer's malignant behaviors. However, these metabolites and behaviors have not been iden
Externí odkaz: https://doaj.org/article/3bc2583b1d8c447a94c847494778f807
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4
Akademický článek
15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival.
Autor: Joseph T O'Flaherty, Yungping Hu, Rhonda E Wooten, David A Horita, Michael P Samuel, Michael J Thomas, Haiguo Sun, Iris J Edwards
Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45480 (2012)
A 15-LOX, it is proposed, suppresses the growth of prostate cancer in part by converting arachidonic, eicosatrienoic, and/or eicosapentaenoic acids to n-6 hydroxy metabolites. These metabolites inhibit the proliferation of PC3, LNCaP, and DU145 prost
Externí odkaz: https://doaj.org/article/f38c19b8db4d4e26bfae1cf6f486c568
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6
Gaia Data Release 1: Testing parallaxes with local Cepheids and RR Lyrae stars
Autor: Clementini, G. Eyer, L. Ripepi, V. Marconi, M. Muraveva, T. Garofalo, A. Sarro, L.M. Palmer, M. Luri, X. Molinaro, R. Rimoldini, L. Szabados, L. Musella, I. Anderson, R.I. Prusti, T. De Bruijne, J.H.J. Brown, A.G.A. Vallenari, A. Babusiaux, C. Bailer-Jones, C.A.L. Bastian, U. Biermann, M. Evans, D.W. Jansen, F. Jordi, C. Klioner, S.A. Lammers, U. Lindegren, L. Mignard, F. Panem, C. Pourbaix, D. Randich, S. Sartoretti, P. Siddiqui, H.I. Soubiran, C. Valette, V. Van Leeuwen, F. Walton, N.A. Aerts, C. Arenou, F. Cropper, M. Drimmel, R. Høg, E. Katz, D. Lattanzi, M.G. O'Mullane, W. Grebel, E.K. Holland, A.D. Huc, C. Passot, X. Perryman, M. Bramante, L. Cacciari, C. Castañeda, J. Chaoul, L. Cheek, N. De Angeli, F. Fabricius, C. Guerra, R. Hernández, J. Jean-Antoine-Piccolo, A. Masana, E. Messineo, R. Mowlavi, N. Nienartowicz, K. Ordóñez-Blanco, D. Panuzzo, P. Portell, J. Richards, P.J. Riello, M. Seabroke, G.M. Tanga, P. Thévenin, F. Torra, J. Els, S.G. Gracia-Abril, G. Comoretto, G. Garcia-Reinaldos, M. Lock, T. Mercier, E. Altmann, M. Andrae, R. Astraatmadja, T.L. Bellas-Velidis, I. Benson, K. Berthier, J. Blomme, R. Busso, G. Carry, B. Cellino, A. Cowell, S. Creevey, O. Cuypers, J. Davidson, M. De Ridder, J. De Torres, A. Delchambre, L. Dell'Oro, A. Ducourant, C. Frémat, Y. García-Torres, M. Gosset, E. Halbwachs, J.-L. Hambly, N.C. Harrison, D.L. Hauser, M. Hestroffer, D. Hodgkin, S.T. Huckle, H.E. Hutton, A. Jasniewicz, G. Jordan, S. Kontizas, M. Korn, A.J. Lanzafame, A.C. Manteiga, M. Moitinho, A. Muinonen, K. Osinde, J. Pancino, E. Pauwels, T. Petit, J.-M. Recio-Blanco, A. Robin, A.C. Siopis, C. Smith, M. Smith, K.W. Sozzetti, A. Thuillot, W. Van Reeven, W. Viala, Y. Abbas, U. Abreu Aramburu, A. Accart, S. Aguado, J.J. Allan, P.M. Allasia, W. Altavilla, G. Álvarez, M.A. Alves, J. Andrei, A.H. Anglada Varela, E. Antiche, E. Antoja, T. Antón, S. Arcay, B. Bach, N. Baker, S.G. Balaguer-Núñez, L. Barache, C. Barata, C. Barbier, A. Barblan, F. Barrado, N.Y. Barros, M. Barstow, M.A. Becciani, U. Bellazzini, M. Bello García, A. Belokurov, V. Bendjoya, P. Berihuete, A. Bianchi, L. Bienaymé, O. Billebaud, F. Blagorodnova, N. Blanco-Cuaresma, S. Boch, T. Bombrun, A. Borrachero, R. Bouquillon, S. Bourda, G. Bragaglia, A. Breddels, M.A. Brouillet, N. Brüsemeister, T. Bucciarelli, B. Burgess, P. Burgon, R. Burlacu, A. Busonero, D. Buzzi, R. Caffau, E. Cambras, J. Campbell, H. Cancelliere, R. Cantat-Gaudin, T. Carlucci, T. Carrasco, J.M. Castellani, M. Charlot, P. Charnas, J. Chiavassa, A. Clotet, M. Cocozza, G. Collins, R.S. Costigan, G. Crifo, F. Cross, N.J.G. Crosta, M. Crowley, C. Dafonte, C. Damerdji, Y. Dapergolas, A. David, P. David, M. De Cat, P. De Felice, F. De Laverny, P. De Luise, F. De March, R. De Souza, R. Debosscher, J. Del Pozo, E. Delbo, M. Delgado, A. Delgado, H.E. Di Matteo, P. Diakite, S. Distefano, E. Dolding, C. Dos Anjos, S. Drazinos, P. Durán, J. Dzigan, Y. Edvardsson, B. Enke, H. Evans, N.W. Eynard Bontemps, G. Fabre, C. Fabrizio, M. Falcão, A.J. Farràs Casas, M. Federici, L. Fedorets, G. Fernández-Hernández, J. Fernique, P. Fienga, A. Figueras, F. Filippi, F. Findeisen, K. Fonti, A. Fouesneau, M. Fraile, E. Fraser, M. Fuchs, J. Gai, M. Galleti, S. Galluccio, L. Garabato, D. García-Sedano, F. Garralda, N. Gavras, P. Gerssen, J. Geyer, R. Gilmore, G. Girona, S. Giuffrida, G. Gomes, M. González-Marcos, A. González-Núñez, J. González-Vidal, J.J. Granvik, M. Guerrier, A. Guillout, P. Guiraud, J. Gúrpide, A. Gutiérrez-Sánchez, R. Guy, L.P. Haigron, R. Hatzidimitriou, D. Haywood, M. Heiter, U. Helmi, A. Hobbs, D. Hofmann, W. Holl, B. Holland, G. Hunt, J.A.S. Hypki, A. Icardi, V. Irwin, M. Jevardat De Fombelle, G. Jofré, P. Jonker, P.G. Jorissen, A. Julbe, F. Karampelas, A. Kochoska, A. Kohley, R. Kolenberg, K. Kontizas, E. Koposov, S.E. Kordopatis, G. Koubsky, P. Krone-Martins, A. Kudryashova, M. Bachchan, R.K. Lacoste-Seris, F. Lanza, A.F. Lavigne, J.-B. Le Poncin-Lafitte, C. Lebreton, Y. Lebzelter, T. Leccia, S. Leclerc, N. Lecoeur-Taibi, I. Lemaitre, V. Lenhardt, H. Leroux, F. Liao, S. Licata, E. Lindstrøm, H.E.P. Lister, T.A. Livanou, E. Lobel, A. Löffler, W. López, M. Lorenz, D. Macdonald, I. Magalhães Fernandes, T. Managau, S. Mann, R.G. Mantelet, G. Marchal, O. Marchant, J.M. Marinoni, S. Marrese, P.M. Marschalkó, G. Marshall, D.J. Martín-Fleitas, J.M. Martino, M. Mary, N. Matijevič, G. McMillan, P.J. Messina, S. Michalik, D. Millar, N.R. Miranda, B.M.H. Molina, D. Molinaro, M. Molnár, L. Moniez, M. Montegriffo, P. Mor, R. Mora, A. Morbidelli, R. Morel, T. Morgenthaler, S. Morris, D. Mulone, A.F. Narbonne, J. Nelemans, G. Nicastro, L. Noval, L. Ordénovic, C. Ordieres-Meré, J. Osborne, P. Pagani, C. Pagano, I. Pailler, F. Palacin, H. Palaversa, L. Parsons, P. Pecoraro, M. Pedrosa, R. Pentikäinen, H. Pichon, B. Piersimoni, A.M. Pineau, F.-X. Plachy, E. Plum, G. Poujoulet, E. Prša, A. Pulone, L. Ragaini, S. Rago, S. Rambaux, N. Ramos-Lerate, M. Ranalli, P. Rauw, G. Read, A. Regibo, S. Reylé, C. Ribeiro, R.A. Riva, A. Rixon, G. Roelens, M. Romero-Gómez, M. Rowell, N. Royer, F. Ruiz-Dern, L. Sadowski, G. Sagristà Sellés, T. Sahlmann, J. Salgado, J. Salguero, E. Sarasso, M. Savietto, H. Schultheis, M. Sciacca, E. Segol, M. Segovia, J.C. Segransan, D. Shih, I.-C. Smareglia, R. Smart, R.L. Solano, E. Solitro, F. Sordo, R. Soria Nieto, S. Souchay, J. Spagna, A. Spoto, F. Stampa, U. Steele, I.A. Steidelmüller, H. Stephenson, C.A. Stoev, H. Suess, F.F. Süveges, M. Surdej, J. Szegedi-Elek, E. Tapiador, D. Taris, F. Tauran, G. Taylor, M.B. Teixeira, R. Terrett, D. Tingley, B. Trager, S.C. Turon, C. Ulla, A. Utrilla, E. Valentini, G. Van Elteren, A. Van Hemelryck, E. Van Leeuwen, M. Varadi, M. Vecchiato, A. Veljanoski, J. Via, T. Vicente, D. Vogt, S. Voss, H. Votruba, V. Voutsinas, S. Walmsley, G. Weiler, M. Weingrill, K. Wevers, T. Wyrzykowski, L. Yoldas, A. Zerjal, M. Zucker, S. Zurbach, C. Zwitter, T. Alecu, A. Allen, M. Allende Prieto, C. Amorim, A. Anglada-Escudé, G. Arsenijevic, V. Azaz, S. Balm, P. Beck, M. Bernstein, H.-H. Bigot, L. Bijaoui, A. Blasco, C. Bonfigli, M. Bono, G. Boudreault, S. Bressan, A. Brown, S. Brunet, P.-M. Bunclark, P. Buonanno, R. Butkevich, A.G. Carret, C. Carrion, C. Chemin, L. Chéreau, F. Corcione, L. Darmigny, E. De Boer, K.S. De Teodoro, P. De Zeeuw, P.T. Delle Luche, C. Domingues, C.D. Dubath, P. Fodor, F. Frézouls, B. Fries, A. Fustes, D. Fyfe, D. Gallardo, E. Gallegos, J. Gardiol, D. Gebran, M. Gomboc, A. Gómez, A. Grux, E. Gueguen, A. Heyrovsky, A. Hoar, J. Iannicola, G. Isasi Parache, Y. Janotto, A.-M. Joliet, E. Jonckheere, A. Keil, R. Kim, D.-W. Klagyivik, P. Klar, J. Knude, J. Kochukhov, O. Kolka, I. Kos, J. Kutka, A. Lainey, V. Lebouquin, D. Liu, C. Loreggia, D. Makarov, V.V. Marseille, M.G. Martayan, C. Martinez-Rubi, O. Massart, B. Meynadier, F. Mignot, S. Munari, U. Nguyen, A.-T. Nordlander, T. O'Flaherty, K.S. Ocvirk, P. Olias Sanz, A. Ortiz, P. Osorio, J. Oszkiewicz, D. Ouzounis, A. Park, P. Pasquato, E. Peltzer, C. Peralta, J. Péturaud, F. Pieniluoma, T. Pigozzi, E. Poels, J. Prat, G. Prod'Homme, T. Raison, F. Rebordao, J.M. Risquez, D. Rocca-Volmerange, B. Rosen, S. Ruiz-Fuertes, M.I. Russo, F. Serraller Vizcaino, I. Short, A. Siebert, A. Silva, H. Sinachopoulos, D. Slezak, E. Soffel, M. Sosnowska, D. StraizYs, V. Ter Linden, M. Terrell, D. Theil, S. Tiede, C. Troisi, L. Tsalmantza, P. Tur, D. Vaccari, M. Vachier, F. Valles, P. Van Hamme, W. Veltz, L. Virtanen, J. Wallut, J.-M. Wichmann, R. Wilkinson, M.I. Ziaeepour, H. Zschocke, S.
Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::f65934b310389516172b6b0f1b3db749
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3069388
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7
15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells
Autor: Haiguo Sun, Joseph T. O'Flaherty, Yunping Hu, Iris J. Edwards
Publikováno v: Carcinogenesis. 34:176-182
Fatty acid metabolism impacts multiple intracellular signaling pathways in many cell types, but its role in prostate cancer cells is still unclear. Our previous studies have shown that the n-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66918483f4b3a5e19094e4ab5f31c9e7
https://doi.org/10.1093/carcin/bgs324
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8
Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer
Autor: Rick T. Owens, Yong Q. Chen, Joseph T. O'Flaherty, Yunping Hu, Iris J. Edwards, Jansheng Wu, Haiguo Sun, Zhennan Gu
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 10, Pp 826-836 (2010)
Evidence indicates that diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFAs) reduce the risk of prostate cancer, but biochemical mechanisms are unclear. Syndecan-1 (SDC-1), a transmembrane heparan sulfate proteoglycan, supports the integrity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c003da96c6d6dedf221175236fa72a
http://www.sciencedirect.com/science/article/pii/S1476558610800508
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9
Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways
Autor: Jiansheng Wu, Iris J. Edwards, Isabelle M. Berquin, Joseph T. O'Flaherty, Rick T. Owens, Yong Q. Chen, Donna L. Perry, Haiguo Sun, Yunping Hu
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 10, Pp 1042-1053 (2009)
Epidermal growth factor receptor (EGFR) and androgen receptor (AR) pathways play pivotal roles in prostate cancer progression. Therefore, agents with dual-targeting ability may have important therapeutic potential. Decorin, a proteoglycan present in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d8ae99e9b99bacae7f8d45c5289b07
https://doi.org/10.1593/neo.09760
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10
Novel translocation responses of cytosolic phospholipase A2α fluorescent proteins
Autor: Rhonda E. Wooten, Susan Sergeant, Larry W. Daniel, Mark C. Willingham, Joseph T. O'Flaherty, LeAnn C. Rogers, Christina C. Leslie
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783:1544-1550
Cytosolic phospholipase A2 (cPLA2)alpha responds to the rise in cytosolic Ca2+ ([Ca2+]i) attending cell stimulation by moving to intracellular membranes, releasing arachidonic acid (AA) from these membranes, and thereby initiating the synthesis of va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc75fe403b89c41fa7b204c638d6cc1
https://doi.org/10.1016/j.bbamcr.2008.03.008
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