Zobrazeno 1 - 10
of 16
pro vyhledávání: '"T. Noelle Lombana"'
Autor:
Changchun Du, Jack Bevers, Ryan Cook, T. Noelle Lombana, Kamalakannan Rajasekaran, Marissa Matsumoto, Christoph Spiess, Jeong M. Kim, Zhengmao Ye
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B are ligands for the a
Externí odkaz:
https://doaj.org/article/ff8ffe1b8bda435d9db38f1f06d4754c
Autor:
C. Andrew Boswell, Gregory Z. Ferl, Amrita V. Kamath, Shang-Fan Yu, Mary Ann T. Go, Christoph Spiess, T. Noelle Lombana, Sheila Ulufatu, Jason Ho, Alecia T. Dent, Anna King, Lauren N. Sermeño, Danielle Mandikian, Madeleine K. Ramos
Supplementary Data and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d20dbeeb5c28537bd9c83b666eae461
https://doi.org/10.1158/1535-7163.22520782.v1
https://doi.org/10.1158/1535-7163.22520782.v1
Data from Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and Penetration
Autor:
C. Andrew Boswell, Gregory Z. Ferl, Amrita V. Kamath, Shang-Fan Yu, Mary Ann T. Go, Christoph Spiess, T. Noelle Lombana, Sheila Ulufatu, Jason Ho, Alecia T. Dent, Anna King, Lauren N. Sermeño, Danielle Mandikian, Madeleine K. Ramos
T-cell–dependent bispecific antibodies (TDB) have been a major advancement in the treatment of cancer, allowing for improved targeting and efficacy for large molecule therapeutics. TDBs are comprised of one arm targeting a surface antigen on a canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd688727755b297ffbdcffd11f0001e7
https://doi.org/10.1158/1535-7163.c.6542773
https://doi.org/10.1158/1535-7163.c.6542773
Autor:
Victor Yip, Eugene C. Chen, T. Noelle Lombana, Daniel D. Bravo, Sharon Viajar, Sophia Lee, C. Andrew Boswell, Wilson Phung, Marissa L. Matsumoto, Jianyong Wang, Avinash Gill, Christoph Spiess, Farzam Farahi, Julie A. Zorn, Wendy Sandoval, Sharmila Rajan, Alberto Estevez, Danielle Mandikian, Claudio Ciferri
Publikováno v:
mAbs
IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent neutralization of pathogens, and ability to transcytose across mucosal barriers via polymeric immunoglobulin rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0d052bb4c77f518c781fd12efc8c3e
http://europepmc.org/articles/PMC6748581
http://europepmc.org/articles/PMC6748581
Publikováno v:
Metabolic Engineering. 52:315-323
Escherichia coli (E. coli) is a promising platform for expression of full-length antibodies owing to its several advantages as a production host (fast growth, well characterized genetics, low manufacturing cost), however, low titers from shake flask
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c640a9b63abc25b5413e39f0c38f7a6
https://doi.org/10.1016/j.ymben.2018.12.009
https://doi.org/10.1016/j.ymben.2018.12.009
Autor:
Mary Ann T. Go, Danielle Mandikian, Christoph Spiess, Lauren N. Sermeño, Gregory Z. Ferl, Madeleine K. Ramos, Shang-Fan Yu, T. Noelle Lombana, Sheila Ulufatu, Jason Ho, Alecia T. Dent, C. Andrew Boswell, Amrita V. Kamath, Anna King
Publikováno v:
Molecular cancer therapeutics. 20(10)
T-cell–dependent bispecific antibodies (TDB) have been a major advancement in the treatment of cancer, allowing for improved targeting and efficacy for large molecule therapeutics. TDBs are comprised of one arm targeting a surface antigen on a canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2a3746841744e82caecb8f0623082f
https://pubmed.ncbi.nlm.nih.gov/34253591
https://pubmed.ncbi.nlm.nih.gov/34253591
Autor:
T. Noelle Lombana, Marissa L. Matsumoto, Jack Bevers III, Amy M. Berkley, Evangeline Toy, Ryan Cook, Yutian Gan, Changchun Du, Peter Liu, Paul Schnier, Wendy Sandoval, Zhengmao Ye, Jill M. Schartner, Jeong Kim, Christoph Spiess
Publikováno v:
mAbs
As an immune evasion strategy, MICA and MICB, the major histocompatibility complex class I homologs, are proteolytically cleaved from the surface of cancer cells leading to impairment of CD8 + T cell- and natural killer cell-mediated immune responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c314ec9eecae57256e1321f873e1664
http://europepmc.org/articles/PMC6343778
http://europepmc.org/articles/PMC6343778
Autor:
Marissa L. Matsumoto, Jack Bevers, Christoph Spiess, Zhengmao Ye, Ryan Cook, Kamalakannan Rajasekaran, T. Noelle Lombana, Jeong M. Kim, Changchun Du
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B are ligands for the activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa72cec0f06e415e8387aad861c14a7
https://doi.org/10.1186/s40425-019-0687-9
https://doi.org/10.1186/s40425-019-0687-9
Autor:
Amy L. Shelton, Ji Li, Rodney A. Prell, Jennifer Johnston, Christoph Spiess, Genee Lee, Kapil Gadkar, James T. Koerber, Amy C. Y. Lo, Klara Totpal, Diego Ellerman, Teemu T. Junttila, T. Noelle Lombana, Maria Hristopoulos, Elaine Mai, Robyn Clark, Dionysos Slaga, Rajesh Vij
Publikováno v:
Science translational medicine. 10(463)
A primary barrier to the success of T cell-recruiting bispecific antibodies in the treatment of solid tumors is the lack of tumor-specific targets, resulting in on-target off-tumor adverse effects from T cell autoreactivity to target-expressing organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c504ec8f56274945f8649306267c5a9d
https://pubmed.ncbi.nlm.nih.gov/30333240
https://pubmed.ncbi.nlm.nih.gov/30333240
Publikováno v:
Scientific Reports
Rapid identification of residues that influence antibody expression and thermostability is often needed to move promising therapeutics into the clinic. To establish a method that can assess small expression differences, we developed a Bacterial Antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24830a8ff74fc0f3d9ad0497f390501
https://pubmed.ncbi.nlm.nih.gov/26631978
https://pubmed.ncbi.nlm.nih.gov/26631978