Zobrazeno 1 - 10
of 20
pro vyhledávání: '"T. Nechuta"'
Autor:
Brian M. Beyer, Vincent Madison, Eric M. Parker, Mckittrick Brian A, Daniel F. Wyss, William J. Greenlee, Corey Strickland, T. Nechuta, Johannes H. Voigt, John C. Hunter, Mary M. Senior, Andrew Stamford, Matthew E. Kennedy, Michael Czarniecki, Yu-Sen Wang, Elizabeth M. Smith
Publikováno v:
Journal of Medicinal Chemistry. 53:942-950
Fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design were used to identify novel inhibitors for BACE-1. A rapid optimization of an initial NMR hit was achieved by a combination of NMR and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b051b98c57bda77146034e6e18e44c2d
https://doi.org/10.1021/jm901472u
https://doi.org/10.1021/jm901472u
Publikováno v:
Tetrahedron Letters. 39:5317-5320
A convenient large-scale preparation of the trifunctional acid 1 has been developed. This acid serves as a useful scaffold for construction of combinatorial libraries incorporating three variable elements in a centro-symmetric array.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b84a7600fa955b3a0d8a7d6002b0efc
https://doi.org/10.1016/s0040-4039(98)01076-4
https://doi.org/10.1016/s0040-4039(98)01076-4
Autor:
Bernard R. Neustadt, Ahmad Fawzi, Ashit K. Ganguly, T. Nechuta, Elizabeth M. Smith, Hongtao Zhang, A. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2041-2044
Combinatorial libraries were constructed based on a hexapeptide endothelin receptor antagonist. Iterative optimization efficiently identified the most active member of the library and allowed preparation of a more potent antagonist.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d06976cdcf1c4bf4efb47befcae6c4
https://doi.org/10.1016/0960-894x(95)00349-x
https://doi.org/10.1016/0960-894x(95)00349-x
Autor:
Edmund J. Sybertz, Robert W. Watkins, Bernard R. Neustadt, Caroline Foster, Alan Bronnenkant, Elizabeth M. Smith, Martin F. Haslanger, T. Nechuta
Publikováno v:
Journal of Medicinal Chemistry. 37:2461-2476
A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acf25fdd183f047f63bbd61d1d84237
https://doi.org/10.1021/jm00041a026
https://doi.org/10.1021/jm00041a026
Autor:
Eric M. Parker, Lili Zhang, Alex V. Buevich, Vaccaro Henry A, Elizabeth M. Smith, John W. Clader, Johannes H. Voigt, Hubert B. Josien, Theodros Asberom, Zhiqiang Zhao, Wei Li, William J. Greenlee, Henry Guzik, Qi Zhang, Thomas A. Bara, Mckittrick Brian A, Lixin Song, Lisa Sinning, Michael McEwan, Dmitri A. Pissarnitski, T. Nechuta
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(1)
A novel piperidine series of γ-secretase inhibitors, potentially useful for the treatment of Alzheimer’s disease, is disclosed. SAR investigation revealed the requirement for cis -stereochemistry of the substituents attached to the core, which res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777d28be5995d3a5bc67a4d80119070c
https://pubmed.ncbi.nlm.nih.gov/17055268
https://pubmed.ncbi.nlm.nih.gov/17055268
Autor:
He. Ling, E. Maxwell, Bo Yaremko, Zhizhang Yin, C. Chandra Kumar, M. Malkowski, B. Neustadt, T. Nechuta, Elizabeth M. Smith, Lydia Armstrong, Judy Varner, Ming Liu
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461368953
The concept that tumor growth is dependent on the formation of new blood vessels as a source of nutrients and oxygen has formed the basis for a novel therapeutic strategy against cancer (Folkman, 1992). The formation of new blood vessels permits rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65ec3956abb1a8dc9b697c3996b081bf
https://doi.org/10.1007/978-1-4615-4221-6_14
https://doi.org/10.1007/978-1-4615-4221-6_14
Autor:
C. Chandra Kumar, Alan Bronnenkant, Bernard R. Neustadt, T. Nechuta, Lydia Armstrong, Lindo Neil A, Arthur Wu, Elizabeth M. Smith
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(17)
A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733d06f016fb2c7d9cf9c4cdd96ea3b2
https://pubmed.ncbi.nlm.nih.gov/9873548
https://pubmed.ncbi.nlm.nih.gov/9873548
Autor:
Edmund J. Sybertz, Elizabeth M. Smith, Martin F. Haslanger, Joel P. Berger, Neustadt Bernard R, T. Nechuta
Publikováno v:
Journal of medicinal chemistry. 32(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948058d817c0819665dfca2d378f0950
https://pubmed.ncbi.nlm.nih.gov/2522989
https://pubmed.ncbi.nlm.nih.gov/2522989
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